Bakgrund: Deposition av fibrillär amyloid beta 1-42 (A?) i hjärnan är ett välkänt kännetecken för den neurodegenerativa sjukdomen Alzheimer?s (AD). Dessa ansamlingar påverkar pericyter, en celltyp involverad i blodkärlsfunktion och upprätthållande av blodhjärnbarriären (BBB). Pericyter uttrycker både receptorn Low density lipoprotein receptor related protein 1 (LRP-1) till vilken A?1-42 binder, och proteoglykanet NG2.

Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected.

The Bovine respiratory syncytial virus (BRSV) causes bronchiolitis and interstitial pneumonia, predominantly in calves, and is a major cause of bovine respiratory disease worldwide. In humans, BRSV is paralleled by the closely related Human respiratory syncytial virus (HRSV), an important cause of respiratory disease, most severe in infants.The clinical signs and pathology during RSV infection is caused, not only by the direct effects of viral replication, but also by the response of the host immune system. The immunopathology of RSV has long obfuscated our understanding of the disease, and development of effective treatment and vaccines will be very difficult until greater knowledge is gained.One of the components of the immune system that has come into focus in RSV research the last few years, is the Toll-like receptor 4 (TLR4). The TLR4 receptor is well known as the receptor that binds lipopolysaccaride (LPS), and initiates the host response to bacterial infection. Recently, it has been shown that the fusion protein of RSV also interacts with, and up-regulates the expression of, the TLR4 receptor.

The Bovine respiratory syncytial virus (BRSV) causes bronchiolitis and interstitial pneumonia, predominantly in calves, and is a major cause of bovine respiratory disease worldwide. In humans, BRSV is paralleled by the closely related Human respiratory syncytial virus (HRSV), an important cause of respiratory disease, most severe in infants.The clinical signs and pathology during RSV infection is caused, not only by the direct effects of viral replication, but also by the response of the host immune system. The immunopathology of RSV has long obfuscated our understanding of the disease, and development of effective treatment and vaccines will be very difficult until greater knowledge is gained.One of the components of the immune system that has come into focus in RSV research the last few years, is the Toll-like receptor 4 (TLR4). The TLR4 receptor is well known as the receptor that binds lipopolysaccaride (LPS), and initiates the host response to bacterial infection. Recently, it has been shown that the fusion protein of RSV also interacts with, and up-regulates the expression of, the TLR4 receptor.

The purpose of this study was to examine whether urea could be an option as a nitrogen source for young cattle, the study was limited to risks related to feeding, growth and feed efficiency. Microbes in ruminants have the ability to convert nitrogen to protein, this has been highlighted by beef producers as they are in search of cheap protein feed resources. Urea can be a worthy source of nitrogen for growing young animals, because of its high nitrogen content and the low price. Studies have shown that the replacement of a portion of the total protein content by urea in diets with low content of crude protein, like corn silage, may improve animal growth and feed efficiency. Replacement of all the true protein with urea can result in reduced feed intake and microbial growth.

Aim: The aim of this study was to determine whether or not there is evidence for the usage of ginger as an antiemetic in patients experiencing chemotherapy related nausea, based on available scientific literature.Methods: The original articles were found by using search engines PubMed and CINAHL. The selected articles were then analyzed based on their content, quality and results. Based on the results from the content analysis the articles were placed in four different themes.Results: In the first theme two of the articles found that ginger had significant effect on chemotherapy related nausea, when used in combination with regular antiemetic treatment. Two other articles said that it does not. In the second theme four studies found that different forms of ginger lessens nausea, in contrast two other articles found that it does not have any increased effect on said nausea.

Bakgrund: Osteoporos är en skelettsjukdom som ökar risken för frakturer. Sjukdomen i sig ärasymtomatisk men frakturerna som uppkommer leder till morbiditet och ökad mortalitet. ISverige beräknas en tredjedel av kvinnorna i åldrarna 70-79 år ha osteoporos i höften ochförekomsten förväntas öka i och med att Sverige får en allt äldre befolkning. En strategi föratt minska risken för frakturer är att öka bentätheten. På senare år har det gjorts flera studiersom undersökt om komjölksprotein kan öka bentätheten.Syfte: Att undersöka om intag av komjölksprotein påverkar benremodelleringen och/eller gerökad bentäthet hos unga människor, vilket skulle kunna leda till ett högre peak bone mass.Sökväg: Sökningar i PubMed och Scopus efter originalartiklar utfördes under april 2011.Sökord som användes var ?Milk AND bone mass/density?, ?Milk protein AND bonemass/density?, ?Milk basic protein AND bone mass/density?.Urvalskriterier: Originalartiklar på svenska/engelska som undersökt effekten av intag avmjölkprotein på bentätheten med hjälp av Dual energy X-ray absorbtiometry (DXA), samt påbenremodelleringen med hjälp av biomarkörer inkluderades.

Syfte: Syftet ?r att sammanst?lla det aktuella forskningsunderlaget f?r att unders?ka om intag av bl?b?r f?r?ndrar lipidniv?er hos m?n och kvinnor ?18 ?r j?mf?rt med att inte inta bl?b?r. Metod: I denna systematiska ?versiktsartikel har en litteraturs?kning genomf?rts. F?r att specificera unders?kningsomr?det har arbetet avgr?nsats till m?n och kvinnor ?18 ?r med interventionen intag av bl?b?r (os?tade f?rska, frysta eller frystorkade) tillsammans med normalkost som har j?mf?rts mot inget bl?b?rsintag (normalkost, placebodryck, -pulver eller -kapsel med pulver). Utfallet som har unders?kts var f?r?ndring av totalkolesterol (TC), triglycerider (TG), low-density lipoprotein (LDL) och high-density lipoprotein (HDL). Studiedesignen f?r inkluderade studier var RCT, minst singelblindad med en interventionsl?ngd p? ?1 vecka.

Syfte: Syftet med denna systematiska ?versiktsartikel var att unders?ka evidensen f?r om intag av bl?b?r har en effekt p? blodlipider m?tt som HDL och LDL hos vuxna med metabola syndromet. Metod: Litteraturs?kningar genomf?rdes i databaserna Scopus och PubMed den 23 mars 2023. S?kningen baserades p? tre stycken block. Ett block inkluderade de olika typerna av blodfetter, det andra blocket inkluderade randomiserade kontrollerade studier (RCT) och det tredje blocket inkluderade bl?b?r.

Mast cells have for a long time been known to accumulate around tumors (Maltby et al., 2009). Studies show that they may be important and sometimes essential in tumor angiogenesis, tumor growth and metastasis of tumors (Soucek, et al., 2007; Xiang et al., 2010). In an expression array study (Wensman et al, submitted manuscript) performed on mouse mast cells exposed to tumor conditioned medium, the gene 4-1BB was among the most up-regulated genes compared to control medium. 4-1BB codes for a membrane receptor protein of the tumor necrosis factor superfamily and has been shown to be important in T cell regulation in tumor diseases. This study was performed to investigate if human mast cells up-regulate 4-1BB when they get exposed to tumor conditioned medium.

Mastitis, an inflammation of the udder mainly caused by a bacterial infection, induces an increase in the somatic cell count (SCC) in milk and is consequently one of several factors affecting SCC in milk. In this literature review it is investigated whether SCC; on udder quarter, cow composite or bulk tank milk level, can be used as a quality marker with focus on milk composition in terms of the content of fat, lactose, total protein, casein and whey protein. According to this literature review the relation between SCC and milk composition is not reliable either on udder quarter, cow composite or bulk tank milk level. SCC was related to lactose, casein and whey protein on udder quarter level; lactose and whey protein on cow composite level and lactose on bulk tank milk level.

Recurrent Airway Obstruction, RAO, är en icke infektiös luftvägssjukdom hos häst. Sjukdomen karaktäriseras av perioder med reversibel luftvägsobstruktion och inflammation orsakad av bronkospasm och ansamling av mucus och neutrofiler i luftvägarna. Sjukdomsorsaken anses vara multifaktoriell med ett samspel mellan dålig miljö och en viss genetisk predisposition. Den immunologiska bakgrunden till sjukdomen är fortfarande oklar men både den förvärvade och medfödda immuniteten anses delta i luftvägsinflammationen. Toll-lika receptorer, TLR, hör till de viktigaste receptorerna i den medfödda immuniteten.

ABSTRACTA defect implantation process is the major reason for unexplained infertility. Estrogen andprogesterone are steroid hormones preparing the endometrium for implantation. They mediatetheir effect through their receptors: estrogen receptor alpha and beta and progesteronereceptor A and B, respectively. Leukemia inhibitory factor (LIF), which is also important forimplantation, mediates its effect through LIF receptor and the coreceptor, gp130, and is downregulated by suppressors of cytokine signaling 1. The aim of the study was to compare thelevels of the steroid hormone receptors and LIF related factors in the endometrium of twogroups of women with the diagnosis unexplained infertility: one that became pregnant afterassisted reproduction and one that did not become pregnant.

An inflammatory reaction is induced after release of proinflammatory mediators such asinterleukin 1 and 6 and tumour necrosis factor ?. These mediators stimulate the liver tosuppress the syntheses of albumin and endure the syntheses of acute phase protein forinstance C-reactive protein. The aim of this paper was to perform a method validation on animmune turbidimetric assay to quantify C-reactive protein in canine serum at the laboratory atSkara Animals Hospital, Skara, Sweden. The validation involved evaluation of the assaylinearity, precision, stability and recovery.The method was proved to be linear for both TruLab control and Medinor control.

Abstract:In previous experiments with the bacterium Ideonella dechloratans a probable sequencecoding for a cytochrome c protein (cyt c) was observed, the sequence is assumed to have afunction in the bacterial respiratory chain. Detection attempts have been made to try to findthis protein, but have not succeeded. The purpose of this project is to detect the expressionof mRNA associated with the cytochrome c. And if it is detected, it will also be investigated ifthere is any difference in expression of the mRNA due to aerobic or anaerobic environment.Total RNA was purified from cultures grown under aerobic and anaerobic conditions. cDNAwas then synthesized using reverse transcriptase and subsequently amplified with thespecific primers in a qRT-PCR.qRT-PCR testing showed a distinct amplification of primer product, confirming that I.dechloratans expresses mRNA coding for the cyt c protein.