Velopharyngeal insufficiency may affect resonance, articulation and thus how speech is perceived by other listeners. Velopharyngeal insufficiency is frequently found in the cleft palate population due to structural abnormalities of the palate. The pharyngeal flap is the most commonly used operation designed to improve velopharyngeal function. The aim of the present study was to compare speech before and after pharyngeal flap surgery by perceptual evaluation regarding nasality, articulation and deviant speech. The study includes preoperative and postoperative speech samples of 28 patients who underwent pharyngeal flap surgery at the University Hospital in Linköping between 2002 and 2007.

African Swine Fever (ASF) is one of the most serious transboundary swine diseases because of its high lethality for pigs, socioeconomic consequences, rapid and international spread and the absence of either treatment or vaccine. This Sida Minor Field Study (MFS) was carried out during fall 2010, as part of a larger collaborative research project called ASFUganda, focusing on the epidemiology of the disease in Uganda. The aim with this study was to get more knowledge about the Pathology in cases of ASF in Uganda, by studying macroscopic and microscopic lesions in pigs with acute and chronic ASF and to detect the ASF virus (ASFV) in tissues by immunohistochemistry. The pigs were selected from the two different geographical locations in Uganda, Mityana and Gulu district, both with on going confirmed outbreaks of ASF. Necropsies were performed in the field, and the laboratory procedures at the JICA (Japan International Cooperation Agency) Veterinary Pathology Laboratory, Entebbe, Uganda, and at the Department of BVF, SLU, Uppsala, Sweden. Three pigs from an outbreak of ASF in Mityana district showed both the history and the clinical symptoms typical for ASF.

Intelligibility is a central concept in speech-language Pathology regarding assessment and treatment of speech. At present, there is no reliable or valid Swedish test for measuring intelligibility. The main purpose of the current study was to conduct a clinical trial of the computer-based intelligibility test ?Swedish test of intelligibility for children? and to investigate the test?s reliability. Another purpose was to investigate the reliability of the rating form ?Intelligibility in context scale?.

Röntgenläkarna väljer ofta att byta undersökningsteknik för att fastställa misstänkt patologi som inte går att diagnostisera med en metod. Vid röntgenundersökningar av sinus (bihålor) så kan läkaren välja mellan konventionell röntgen eller en datortomografiundersökning. Skälet är att diagnoser som tumör, benpåverkan eller ansiktstrauma inte avbildas lika bra med den konventionella metoden. Syftet med den här studien är att jämföra datotomografi och konventionell röntgen vid sinusundersökningar, vilka för och nackdelar som de olika metoderna har, hur bildinformationen och diagnostiken skiljer sig, vilka risker som finns med joniserad strålning samt vilka biologiska effekter strålningen har på människan. Intervju har gjorts med odontologi läkare som berättat om för och nackdelar med de olika metoderna, och litteratur och artiklar har gett kunskap för att komma fram till resultatet.

The purpose of this study was to examine if there were anychanges in quality in the voices of speech and language Pathology studentsafter four years of study at the University of Gothenburg. Recordings oftwenty student voices from the first and eight semesters were evaluatedperceptually by six speech-language pathologists. The parameters judgedwere: vocal fry, glottal attacks, strain, breathiness and resonant voice, usinga scale from 0 to 10. Acoustical measures were made of F0 mean andmedian to detect possible differences between the two recordings. Theresults show a significant decrease in vocal fry, glottal attacks and strain aswell as an increase in resonant voice and a significant decrease in F0 meanand median.

The purpose of this study was to investigate the effects ofparticipation in an integrated intensive stuttering program (IST) on stutteringbehavior, intelligibility and communication attitude, at individual and grouplevels. Five children aged eight to twelve years participated in the study.Stuttering behavior and intelligibility were judged by two independentstudents in speech and language Pathology based on a total of eight videorecordings, before, during and after therapy. Communication attitude wasmeasured by the Swedish version of the self-report questionnaireCommunication Attitude Test (CAT-S). At an individual level, the initialstuttering profile and the changes shown during and after the IST varied. Ata group level, a significant decrease in stuttering frequency and asignificantly higher level of intelligibility were found, after as compared tobefore therapy.

A historical study of intervention for aphasia may provide information on how speech and language pathologists work with people with aphasia. Aphasia is seen as an umbrella term for symptoms of language disorders caused by aquired brain injury. The overall aim of the present study was to describe and analyze the development of intervention for aphasia during the periods 1990-1999 and 2000-2010.The study was conducted by analysis of 83 medical records from two hospitals in Sweden during a period of 20 years. These decades were compared to each other and yo current litteraturein search for differences and trends in aphasia intervention.The Results of the present study revealed that intervention mainly focused on recovering the linguistic ability in both the 1990s and 2000s. Intervention and literature focusing on communication seem to increase during the 2000s.

Storytelling is a complex action that requires many linguistic and other cognitive abilities, like memory and attention. Resent research has shown a correlation between oral story retelling and picture arrangement among children with neurodevelopmental disorders. The present study analyzes if this correlation exists among a convenience sample of children from the general population. 77 children between 3:11 and 9:0 years old accomplished Bus Story Test and a picture arrangement task from WISC III. Significant correlations was found between picture arrangement and Bus Story Test?s subscores sentence length, subordinate clauses and information.

Jumper´s knee is a common overuse injury due to repetitive microtrauma to the patellar tendon. It is especially common among athletes who are involved in sporting activities that involve jumping or fast running. The term jumper´s knee was adopted after Blazina published his original paper in 1973. Its Pathology can be considered as a partial or total rupture of the patellar tendon in one of its three insertions. The aim of this literature study was to review the methods used to treat this condition and the results obtained focusing on pain relief and returning to previous sport or level of activity.

Confrontation naming is commonly used in speech and language Pathology to diagnose neurogenic communication disorders and evaluate naming ability. The existing Swedish assessment instruments for adults consist of pictures depicting nouns. In this study, parts of the instrument An Object and Action Naming Battery were used, containing pictures depicting both nouns and verbs. The study?s purpose was to explore the degree of difficulty in the material, based on the naming of the participants, and examine whether different variables correlate with the results in confrontation naming.

Duchenne Muscular Dystrophy (DMD) is a hereditary X-linked fatal disease that affects 1 in 3500 male births. It is the most common kind of muscular dystrophy in children and leads to death in the late teens or early 20s for many patients. The mdx mouse is a model of DMD that can be used to investigate experimental therapies. Overexpression of a glycosyltransferase, CT GalNAc, in mdx mice has been demonstrated to prevent the development of muscular dystrophy. Overexpression of another glycosyltransferase, LARGE, is currently being investigated as a treatment for another group of muscular dystrophies, the dystroglycanopathies. In this study, we overexpressed LARGE in mdx mice in order to investigate its effect on the development of muscular dystrophy.

An instrument for assessing children's attitude towards speech,communication, and communicative participation suitable for children withcleft lip and palate has been missing in speech- and language Pathology. Inthe present study a new instrument Självsvarsformulär Om Tal OchKommunikation was tested on typically developed school children. The aimwas to obtain norm values for children in grade 4 and 7 and to examine thereliability and validity of the instrument. 104 children participated. Data wascollected in groups of 5-6 children.

In the beginning of the 1990?s ratite breeding for meat production was introduced in many European countries, including Sweden. The knowledge of ostrich farming and diseases of ratites is increasing internationally but is still often limited among veterinarians. This report consists of a literature study and a summary of Pathology findings from ratites submitted for necropsy to the National Veterinary Institute (SVA) in Uppsala, during 1995 to 2001. The purpose is to give a general introduction to ostrich and ratite breeding and to give an overview of the most common diseases. The necropsy data from 1995 to 2001, indicate that many of the diseases are management related rather than caused by infectious agents. Due to cold climate ostrich breeders in Sweden need to supply well designed buildings and good care of the animal.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

In couples diagnosed with unexplained infertility, the woman has normal ovulatory cycles and no organic Pathology, and the man has normal semen. The period during which the implantation of an embryo can occur is defined as the window of implantation (WOI). For infertile women, disturbances in the endometrium maturation are hypothesized to impair the uterine receptivity for embryo implantaition. However, there are still no methods found to predict endometrial receptivity.Hemoglobin related-proteins hypothesized to be involved in embryo implantation have been found in the endometrium in both fertile and infertile women. The aim of this study was to determine whether there were differences in the expression of hemoglobin-related proteins, hemoglobin-?, cytoglobin, fetal hemoglobin and haptoglobin in the endometrium of fertile and infertile women.