The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

The Swedish old-age care will in the near future face an extensive need to recruit enrolled nurses by virtues of the demographical development. The generation born in the 1940s will soon retire, and at the same time the rest of the population is growing older. One thing that becomes more important in how to draw more people to the old-age care, is to understand how the ones who allready work there experience their own worksituation.The purpose of this study was to find out how enrolled nurses from two different generations experienced their own occupational role and make similarities and differences between the two generations experiences visible. The topics of interest in our study are the respondents own thoughts about their education, their worksituation today, what they think of the future and how they believe others regard their work. To fulfill the purpose of our study we used qualitative interviews.

Aim: The aim of this study is to examine how managers apprehend today's leadership and how they believe that future leadership will be influenced and developed when the people bourn during the nineteen forties pass on their management positions to a younger generation.Method: I share the hermeneutic view on science. I believe that knowledge is born with in the person who seeks to obtain it. I have chosen to conduct my study using a qualitative and inductive approach. I use an inductive approach as I answer my questions by using interviews in order to respond to my question at issues, and assumes from the empiric in my study.Result & Conclusions: The leadership role has changed from being? the one who decides?,? the director?, to becoming less peculiar and prestige.

This report is part of the major thesis carried out at Stoneridge Electronics in Bromma,Stockholm during autumn and winter 2005-2006. The background to the thesis is the trendwithin the automotive industry where color displays have become more common for presentationof information to the driver, a trend that has come to the commercial vehicle market. Thepurpose of the thesis has been to evaluate whether programmable logic, with respect to FPGAtechnology, could be suitable for display control and graphics generation of these more complexcolor displays in automotive environment.Within the scope of the thesis the FPGA technology has been investigated, i.e. whatopportunities and threats there are with aspect to environmental and security requirements. Inaddition, the market of FPGAs and pre-built IP-cores has been investigated.

People born 1940-1949 will be more demanding regarding help from the elder care than previous generations. The explanation often proposed is that people born in the 1940?s grew up after the Second World War when cultural changes took place in society. The aim of this qualitative study was to describe the social needs of people born in the 1940?s today, in order to make cautious assumptions about what type of social needs elder care is likely to face in the future, when the older people becomes in need of elder care.

Bachelor thesis, Degree of master in Science and Economics, School of Business and Economics at Linnaeus University, Management, 2FE01E, Spring Semester 2013Author: Johanna Björklund, Sarah Gustafsson and Sofia NicklassonMentor: Anders HytterTitle: Retention: Why stay when your options are unlimited? Background: Employee turnover is a problem today, and companies face increasing challenges when it comes to retain employees within the organization, so called employee retention. This is a present concept and theory holds that more organizations realize that they need to put more focus on retention as one of their business goals to remain competitive. It?s important that organizations understand individuals' different needs and the factors that make them satisfied in their professional life.

In this paper the authors examine three questions: 1) Is stealth marketing messages posing as status updates on Facebook a more effective way of advertising than traditional web banners? 2) What impact has learning about stealth marketing practices in social media on consumer attitude and post purchase behaviour? And finally 3) Will different generations respond differently to these questions?Our findings show that stealth marketing in social media is not more effective than traditional web banners. Furthermore, the result indicates that when consumers find out about stealth marketing practices it will have a negative impact on future purchase intensions and brand image. Most consumers will also have strong feelings of being deceived, which could instigate harmful post purchase behaviour such as negative word-of-mouth and possibly, based on some earlier cases, boycotts.The result of our research shows that the brand perceptions and future purchase intentions of Generation Y, persons between 18 and 30 years of age, are affected in a less negative way than the brand perceptions and future purchase intentions of older generations when finding out about stealth marketing practices in social media. However Generation Y:s reaction is still negative and they do consider traditional web banners to be more credible than status updates on Facebook.

Sverige kommer inom en snar tid att stå inför stora förändringar på arbetsmarknaden gällande generationer. Baby boom generationen kommer att gå i pension och arbetsmarknaden tas över av generation X och Y. Genom att baby boomers lämnar arbetslivet och tar med sig sina kunskaper, blir det ett stort tomrum som kan vara svårt att fylla av de nästkommande generationerna. Emellertid har generation X och Y andra kunskaper som baby boomers saknar. Karakteristiska värderingar återfinns hos de olika generationerna, exempelvis värdesätter baby boomers hårt arbete och lojalitet.

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SammanfattningTitel: Hur pa?verkar Gerillamarknadsfo?ring Generation Y? A?mne/Kurs:  Fo?retagsekonomi - KandidatuppsatsHandledare:  Lars HaglundNyckelord: Marknadsfo?ring, Gerillamarknadsfo?ring, Generation Y, Annonsering, Word-of-mouth, Buzz- marknadsfo?ring, varuma?rkesattityd, varuma?rkesengagemang, engagemang online, kommunikation.Bakgrund: Marknadsfo?ring handlar om att skapa och utveckla lo?nsamma kundrelationer. I dagens samha?lle sa? sker marknadsfo?ring runtom omkring oss hela tiden. Pa? grund av detta har Generation Y utvecklat strategier som automatiskt sorterar bort o?verflo?dig och ono?dig information.

The purpose of this thesis was to study the origin of the local news in local newspapers. Do the news originate mostly from the police, the municipality, from press releases or from the reporters own ideas? We also wanted to find out what kind of content predominated in texts with its origin in press releases respectively the reporters own ideas. Of course we also wanted to find out if there were any similarities or differences between the two studied newspapers.We used a type of constructed week, but with non random selection instead of random. We chose one of each weekday the newspapers were published and studied the news covered in the papers that specific day.

I denna uppsats beskrivs och implementeras tre alternativa metoder för att skatta kovariansen mellan finansiella tillgångar. De utvärderas sinsemellan och jämförs med stickprovskovariansen. Utvärderingsmodellen innebär simulering av en aktiv portföljförvaltare i en verklighetstrogen miljö. Då kovariansen mellan finansiella tillgångar beräknas med stickprovsskattning blir skattningsfelet stort. Detta fel, eller brus, försämrar portföljförvaltares resultat och alternativa metoder eftersöks.

I den ha?r uppsatsen fo?rses la?saren med en uppfattning om vilken roll nationella kulturskillnader spelar i globala virtuella team besta?ende av Generation Z. Vi fokuserar pa? dimensionen individualism-kollektivism, och gruppdynamik i globala virtuella team ur fo?ljande perspektiv; fo?rtroende, o?msesidigt beroende, kommunikation, samt relations- och uppgiftsrelaterade konflikter. Utifra?n va?r litteraturgenomga?ng formulerar vi tva? hypoteser; 1) att nationella kulturer ha?ller pa? att fo?ra?ndras, och 2) att nationella kulturskillnader inte upplevs existera la?ngre, vilka vi underso?ker genom en kvantitativ enka?t som skickats ut till studenter fra?n hela va?rlden.Va?rt resultat visar pa? att skillnader i nationell kultur har minskat inom vissa omra?den, som kommunikation och konflikthantering, medan de fortfarande a?r na?rvarande na?r det kommer till fo?rtroende och o?msesidigt beroende.

When a person of the older generation in a family owned company wish to transfer his ownership to a person in the younger generation this can be done through a succession of generation. Different methods can be used to proceed with such a matter, selling the company shares for a price below the market value is one example of this.When the owner transfers shares to a person in the younger generation, either as a gift or by selling them to a price below the market value, the provision in the 7th chapter 4 § ÄB can be applicable. This provision establish that; when a gift that has been given during the grantors lifetime and when the purpose of this gift is to be equivalent to a testament, the gift shall be returned to the receiver if this action confines with the direct heirs statutory portion.A gift is to be equivalent to a testament when the giver had the intention to arrange the succession when the gift was given away, and when this gift did not amount to any economical sacrifice for the giver. There are two situations which causes a gift to be equivalent to a testament. The first situation arises when the gift is given by the giver right before his death, on his deathbed so to speak.

Vi har valt att undersöka den pågående generationsväxling som sker på arbetsmarknaden, den äldre generationen börjar nu gå i pension och den yngre generationen börjar i allt högre grad röra sig in på arbetsplatserna. Ämnet har länge legat till grund för forskning och det har förutspåtts att de stora pensionsavgångarna skall leda till stor arbetskraftsbrist. Detta är inget som vi ser på dagens arbetsmarknad utan det är istället arbetslösheten bland unga som är det mest framträdande. Forskning om det förmodade generationsskiftet har länge vart aktuellt, men verkar nu börja närma sig i och med att pensionsavgångarna beräknas tillta. Samtidigt som de yngre årskullarna börjar minska i antal.