The ability to tackle NP-hard problems has been greatly extended by the introduction of Metaheuristics (see Blum & Roli (2003)) for a summary of most Metaheuristics, general problem-independent optimisation algorithms extending the hill-climbing local search approach to escape local minima. One of these algorithms is Iterated Local Search (ILS) (Lourenco et al., 2002; Stützle, 1999a, p. 25ff), a recent easy to implement but powerful algorithm with results comparable or superior to other state-of-the-art methods for many combinatorial optimisation problems, among them the Traveling Salesman (TSP) and Quadratic Assignment Problem (QAP). ILS iteratively samples local minima by modifying the current local minimum and restartinga local search porcedure on this modified solution. This thesis will show how ILS can be implemented for MSA.

Syfte: Studiens syfte var att jämföra en ny extubationsalgoritm med sedvanligtextubationsförfarande. Gruppen som studerades var patienter som genomgått en HIPEC-operationoch vårdats på Centrala intensivvårdsavdelningen.Metod: I En randomiserad kontrollerad klinisk pilotstudie randomiserades patienterna till en av tvågrupper. Därefter extuberades patienten enligt en studiealgoritm eller post-operativ standard.Resultat: Syresättningen var väsentligen oförändrad för studiegruppen (37,5 kPa till 36,6 kPa)medan den sjönk för kontrollgruppen (50,1 kPa till 40,6 kPa) vid jämförelse mellan 10 minuter efterankomst och 15 minuter efter extubation. Efter 13 till 18 timmars kontroll strax innan patienternalämnade intensivvårdsavdelningen var syresättningen på samma nivå som 15 minuter efterextubation för både studiegruppen och kontrollgrupp. Således kvarstod en försämrad syresättninghos kontrollgruppen vid utskrivning jämfört med 10 minuter efter ankomst.Slutsats: Studien visar att det skulle kunna vara fördelaktigt att extubera patienter enligt denstudiealgoritm som testats jämfört med dagens kliniska standard.

Background: Surgical complications has been the main cause of medical injuries and deaths worldwide. In 2008 WHO developed the checklist for safe surgery to reduce the number of surgical complications. The objective of the checklist is to strengthen already established safety routines and contribute to better cooperation and communication. Research shows that compliance to the checklist is deficient, which can affect patient safety.Aim: The aim was to study the extent to which theatre nurses participate in the use of the checklist.Method: Observational study was conducted with a descriptive design and quantitative approach. 24 observations were carried out with aid of an observation protocol of two surgical units at a hospital in central Sweden.Result: The results showed that Timeout initiated widely but compliance to all items was considerably lower.

Barnen är den grupp i samhället som använder datorer allt mer och mer. Idag finns det pedagogiska lärospel som ska hjälpa barnen med att lära sig skriva, läsa och räkna i skolan. Vi har intresserat oss för dessa typer av spel och vi har i denna uppsats undersökt hur ett sådant spel kan hjälpa barn och vad det är i spelet som representerar ett lärande. Vi har använt oss utav ett spel vid namn Läslandet från Läramera AB och gjort observationer med hjälp av en metod som varit av både kvantitativt och kvalitativt slag. Den kvantitativa ansatsen bestod i att vi använde oss av strukturerade observationer och det kvalitativa låg i att vi använde oss utav Think Aloud protocol.

Animals in zoos live in small enclosed areas. If a pathogen is introduced to the zoo, the animals are extremely vulnerable. The highest risk of introducing new pathogens occurs when new animals are introduced to the collection. Therefore it is essential that zoos have a protocol in place for disease prevention. This review has studied literature on the subject of disease prevention protocols when translocating animals between zoos.

The effects of dexmedetomidine and butorphanol sedation on skin reactivity during intradermal testing in healthy dogs were evaluated. The effects of dexmedetomidine and butorphanol were compared to medetomidine, a sedative agent having scientific proof of not interfering with skin test reactivity, in a randomised, double blind, cross over study performed on 8 adult dogs. The dogs were sedated with medetomidine (Domitor vet.®, 0,01 ml kg-1) intravenously, or dexmedetomidine and butorphanol intramuscularly (Dexdomitor vet.®, 0,01 ml kg-1; Dolorex vet., 0,01 ml kg-1) after which they received intradermal injections of positive control solutions (histamine 0,1 mg ml-1, 0,05 mg ml-1, 0,025 mg ml-1), a negative control solution (0,9 % NaCl) and allergen extract (Dermatophagoides farinae, Cladosporium and Artemisia vulgaris). After a wash out period the trial was repeated with a reversed sedation protocol.Skin reactivity (wheal size, induration and erythema) and quality of sedation (immobilization, response to stimuli and injections as well as over all working conditions) were evaluated. The combination of dexmedetomidine and butorphanol provided reliable, good sedation and analgesia without adverse effects.

First-year students at Linköping University have developed a prototype that graphically visualizes a medical record in a new way. The customer of that project was the Department of Biomedical Engineering at Linköping University. They now want a usability evaluation to be performed of the prototype. The prototype is to be used by employees in the public health care and is supposed to be used on a small portable unit with a multi-touch interface. For this reason the prototype will be used as a complement to existing systems when the users work near the patients.

Since their invention in 1999, CubeSats have become a widespread standard for small picosatellite missions. CubeSats allow for quick development of satellite payloads and launch in space without the high costs of a normal satellite. Emphasis during the CubeSat design process is placed on use of commercialoff- the-shelf (COTS) components and reuse of previously-designed units.This report describes the interfacing of a scientific magnetometer, the Small Magnetometer in Low-Mass Experiment (SMILE) to such a CubeSat mission, the Space Weather using Ion spectrometers and Magnetometers (SWIM). Design of a complete platform for use in multiple such missions is presented here.Modularity is one of the key aspects followed in the course of the work. A new board containing the analog pick-up and compensation circuitry for SMILE has been designed to fit inside a CubeSat frame.

Holmström, M & Jangvert, M Protokolliserad urträning från respirator. Att ha en plan är viktigare än hur den ser ut och en plan fungerar bara om du använder den. Examensarbete i omvårdnad 15 högskolepoäng. Malmö högskola: Hälsa och samhälle. Utbildningsområde omvårdnad 2011. Respiratorbehandling är en livsavgörande behandlingsinsats för kritisk sjuka in-tensivvårdspatienter.

Syftet med den här undersökningen är att ta reda på vilka avtryck ett kompetensutvecklingsprojekt i svenska som andraspråk sätter hos de deltagande lärarna och deras undervisningspraktik. Kompetensutvecklingen genomfördes på en skola där majoriteten av eleverna är flerspråkiga och måluppfyllelsen är låg. I studien följs tre lärare under projektets gång, dvs. över två terminer. Undersökningen har drag av ett aktionsforskningsprojekt, då jag har varit både lärarnas handledare under kompetensutvecklingen samt genomfört undersökningen.

Konsekvenserna av långvarig ventilatorbehandling i form av ökat antal komplikationer och ökade kostnader är väl dokumenterade. Patienten behöver tränas ur ventilatorn med en adekvat metod, utan fördröjning. Urträningsprotokoll kan minska risken för ineffektiv vård och medicinska misstag genom att tillhandahålla en enhetlig strategi och gemensam terminologi. Syftet med studien var att beskriva innehållet i de ventilatorurträningsprotokoll som förekommer inom Svenskintensivvård. Studien utgjordes av en totalundersökning där samtliga svenska intensivvårdsavdelningar tillfrågades om de hade urträningsprotokoll.

The purpose of the present study was to study if the systemic blood pressure in cats significant increases due to stress associated with a visit to a veterinarian clinic. We also wanted to investigate the clinical utility of two different methods for indirect blood pressure measurements in cats by assessing how easy they were to use and how reliable measurements they provided. The methods that were used were oscillometric (Memo Diagnostic) and ultrasound-doppler technique (Minidop). The blood pressure was measured in both clinical environment and home environment. Fifty cats were used in the study, from which measurements were impossible to obtain in one cat.

Electroretinography is an examination method where the function of the retina is objectively assessed. In 2002 the European College of Veterinary Ophthalmology (ECVO) published a proposition to a standard on how to perform ERG examinations, to facilitate comparison of results and to make it possible to repeat examinations. The purpose of this study was to validate parts of the canine ERG protocol suggested by the ECVO. Our principal aim was to study if there is any interference at the recommended stimulus intervals for dark-adapted rod- and combined rod-/cone responses. The results show that there is an effect on the a- and b-wave amplitudes when different stimulus intervals are employed. When all examined intervals are pooled, there is an increase in the median b-wave to each consecutive dim, white (rod) stimulus in a series of four.

Background: Surgical complications has been the main cause of medical injuries and deaths worldwide. In 2008 WHO developed the checklist for safe surgery to reduce the number of surgical complications. The objective of the checklist is to strengthen already established safety routines and contribute to better cooperation and communication. Research shows that compliance to the checklist is deficient, which can affect patient safety.Aim: The aim was to study the extent to which theatre nurses participate in the use of the checklist.Method: Observational study was conducted with a descriptive design and quantitative approach. 24 observations were carried out with aid of an observation protocol of two surgical units at a hospital in central Sweden.Result: The results showed that Timeout initiated widely but compliance to all items was considerably lower.

Background: Vacuum assisted closure, VAC, is a method which can benefit wound closure. There are not many reliable studies about the effects of VAC in different types of wounds. Previous studies have shown that patients have experienced pain during dressing changes.Aim: The aim of the study was to survey in what kind of wounds the vascular surgery ward have been using VAC, to study the treatment process of VAC and how it has been documented and also to investigate if patients with VAC experienced pain during dressing changes.Method: The patients were chosen from a ledger, which contained 77 patients that had been treated with VAC on the vascular surgery ward. Data were collected with a journal survey protocol.Results: The result is based on 67 patients with a total of 79 wounds. VAC was shown to have a good effect on wound healing and infected surgical wounds were the most commonly wound category undergoing treatment with VAC.