Fetma är ett tillstånd som har visat sig öka risken för utvecklandet av metabolt (MS) syndrom hos människa. MS karaktäriseras av fetma (framförallt bukfetma), insulinresistens (IR), diabe-tes mellitus och högt blodtryck. Idag anses fetma även vara en av orsakerna till utvecklandet av ekvint metabolt syndrom (EMS) som ses hos hästar. EMS liknar till stor del den sjuk-domsbild som ses hos människor med metabolt syndrom. Förutom fetma är regionala fettan-sättningar och IR vanligt förekommande hos dessa hästar som ofta även utvecklar fång.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Flera av de metoder som används för att diagnostisera hypofysär pars intermedia dysfunktion (PPID) bygger på att mäta hormonnivåer, framför allt kortisol eller ACTH, i Plasma. Det har dock visat sig att tolkningen av testerna kan vara osäker delvis på grund av att utsöndringen av dessa hormoner normalt varierar under året. I litteraturstudien presenteras metoder som används för diagnostisera PPID idag och metoder som studeras för att få en möjlighet till säkrare diagnosställande. I detta examensarbete sammanställs resultaten från drygt fem års dexametasonhämningstester (DT) som utförts i Sverige och som analyserats av Klinisk kemiska laboratoriet, Universitetsdjursjukhuset Uppsala (UDS). Etthundra enkäter angående de hästar med Plasmakortisolvärden ovan 10 nmol/l men under 100 nmol/l skickades ut till ansvarig veterinär för att utreda om resultatet på testet verkade överensstämma med den slutliga diagnosen.

Today most dosages used in horse medicine are based on studies in adult horses. Since there are differences between adult and neonatal horses with respect to different pharmacological parameters this can cause problems when administring drugs to neonatal foals. Neonatal sepsis is a common cause of morbidity and mortality in foals and aggressive antibiotic treatment is needed immediately when sepsis is suspected. In Sweden the combination of trimethoprim/sulphadiazine and bensylpenicillin is often used as the initial treatment. When administering drugs, interactions can occur between the drugs and endogenous substances.

Studiens målsättning var att besvara tre frågeställningar. Skiljer sig andningsfrekvensmönstret efter ansträngning hos varmblodstravare med prestationsnedsättning från normalpresterande hästar? Påverkas andningsfrekvensmönstret efter ansträngning av en ökad slemansamling i luftstrupen? Är koncentrationen surfaktantprotein D i blodet en relevant analysparameter vid utvärdering av nedre luftvägsproblem? Hypotesen var att travhästar med subkliniska luftvägsproblem i de nedre luftvägarna har en längre återhämtningsperiod efter ansträngning jämfört med friska hästar. Kopplingen mellan ökad slemansamling i luftstrupen och prestation undersöktes också. 24 varmblodstravare deltog i försöket. Innan försöket undersöktes varje häst kliniskt inkluderande vilo-EKG och luftvägsendoskopi.

Endotoxinemi hos häst ses framförallt i samband med sjukdomar i mag- och tarmkanalen. De metabola rubbningarna och den utbredda inflammationen som endotoxinemin medför, gör att det är ett allvarligt tillstånd som kräver veterinärvård. Förändringar i aminosyrametabolismen har setts hos människor med experimentellt inducerad endotoxinemi och patienter med sepsis. Den kraftigt ökade muskelnedbrytning som endotoxinemi medför anses ha stor betydelse för patientens återhämtningsförmåga och prognos för överlevnad. Förutom aminosyrornas egenskaper som byggstenar för produktion av protein har de en viktig funktion för cellsignalering, bidrar till bevarandet av ett fullgott immunförsvar och hämmar cellskador.

Milk fever, or parturient paresis, is the second most common disease in Swedish dairy cows. The disorder is associated with the onset of lactation when some cows are unable to meet the metabolic demands of calcium to support milk production and therefore develop a state of hypocalcaemia. Clinical hypocalcaemia (milk fever) may lead to coma and death in severe cases but subclinical hypocalcaemia has also been shown to have negative effects on e.g. feed intake and production and to increase the susceptibility of the cow to develop secondary diseases. The nutritional strategy applied precalving is of great importance in preventing milk fever and e.g.

Ten colic horses and seven healthy horses were included in a prospective study aiming to evaluate acid-base disturbances in colic horses. Traditional acid-base methods and measurements of lactate were used to study prognosis and changes before, during and after surgery. Strong ion gap, anion gap and base excess were compared to evaluate their ability to predict lactate. Of the ten colic horses that went through surgery, seven survived, two were euthanised and one died. Significant differences in Plasma lactate levels were seen between the group of survivals and non-survivals, p=0,000025. No differences were seen in pH and base excess between the two groups.

A shorter dry period length has in studies abroad showed some positive effects among high yielding dairy cows. Among other things it has been suggested that the periparturient metabolic stress becomes lower, that the fertility is improved and dry off becomes gentler for the udder, due to a lower milk yield. The milk yield is generally reduced during the first period after calving, especially among primiparous cows. The aim of this master thesis was to investigate how Swedish cows were affected by a shortened dry period, regarding milk yield, metabolism, health, body condition and body weight from two months before calving to some weeks after calving. Also Plasma concentration of lactose during the period before calving was determined.

Blodcirkulationen är essentiell för människans överlevnad. När blodets koagulation- och antikoagulationssystem kommer i obalans kan koagelbildning orsaka venös tromboembolism, blodpropp. Patienter som har haft en blodpropp behandlas med antivitamin K-läkemedel (Waran®) för att förebygga recidiv. Dosen är individanpassad och för att erhålla rätt terapeutisk verkan krävs övervakning genom mätning av protrombinkomplex i Plasma.Syftet med studien var att utföra en utvärdering samt göra en hållbarhetsstudie på en ny provtagningsrutin för kapillära protrombinkomplex.I studien ingick 48 personer varav 33 män och 15 kvinnor. Åldersfördelning var 22-88 år och medianålder var 62 år.

In this study the opioid buprenorphine was given to 8 clinically healthy goats. The pharmacokinetics and behavioral effects were studied. Injections of buprenorphine, 0.02 mg/kg body weight was given both intramuscularly (i.m.) and intravenously (i.v.) with a cross over design. The results showed a short half-life of the drug in the Plasma, 65.9 ± 17.4 min (mean ± SD), after i.v. injection.

Peritonitis is a potentially life-threatening disease in horses. With no published work from Sweden, the objective of the study was to describe the occurrence and demographics of horses with peritonitis and to evaluate the outcome of treatment in terms of short-term survival during a ten-year period in a large clinic in Sweden. Data were examined in a retrospective manner in 69 horses diagnosed with and treated for peritonitis at Universitetsdjursjukhuset (UDS) in Uppsala between 2002-2012. Demographic data examined included age, breed, gender, history, duration of illness before arriving at UDS, reason for seeking veterinary care, initial clinical findings (general state of health, heart rate, respiratory rate, mucous membrane appearance, rectal temperature, abdominal sounds, rectal examination, nasogastric tube results), abdominocentesis results (abdominal fluid analysis including visual inspection, leukocytes and protein, cytology, bacterial culture and sensitivity pattern), complete blood count (CBC), Serum amyloid-A (SAA) upon presentation and a follow up, Plasma fibrinogen, Plasma protein and albumin, treatments, length of hospitalisation and outcome. All medical records with the diagnosis of peritonitis were extracted from the medical records system Trofast. All records with any other diagnosis code referring to trauma such as rectal tear or ruptured uterus, recent abdominal surgery, external trauma or rupture in the gastrointestinal tract were excluded. To be included in the study, the peritoneal fluid should contain more than 20.000 cells/?L, have a peritoneal protein value of >30 g/L; or have a significantly changed peritoneal fluid sample (orange with increased turbidity or worse) in cases where no data on cells or protein were available. The horses were divided into two groups; one where the peritonitis was deemed to have an idiopathic aetiology (primary peritonitis) and the other group where the peritonitis had a possible aetiology such as intestinal parasites, impaction etc.

Twitching is frequently used in horse management because of its sedating and pain-relieving effects. In this study, the effects on the horse?s nervous system by twitching were investigated by thermography of the skin temperature. The temperature is regulated by the sympathetic nervous system through postganglionic sfincters at the capillaries of the skin. The effects on the endocrine activity have also been studied by the measuring of ACTH and cortisol in blood Plasma.