Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

Because of increasing demand of power on Malmbanan the capacity of the existing wires which supply the trains must be increased. This increases the stress on the existing poles and for this reason the system for supplying the loads along the railway is to be removed from the poles and be replaced by some other system. This thesis is a study on a two-level low voltage (1 kV and 0.4 kV) electrical system with the aim to investigate if it can be an alternative to the system used today taking into account the voltages, fault currents and costs.In this thesis the following tasks have been performed:? Gathering of data? Description of basic theory? Loadow and fault current calculations of the system with MATLAB? Life Cycle Cost estimate of the system? Analysis and conclusions from the resultsThe results show that the new system can be an alternative to replace today's system. The simulations and calculations show that the voltage drop is at an acceptable level and that the fault currents are large enough to supply a safe disconnection if a fault occurs at the far end of the system..

In this thesis you will be able tofollow the design work of a drumtest. A tool that by having a rotatingdrum with equally positioned obstacleswill simulate the conditions a mountainbike rim will pass through.Initially there is a specification ofsome parameters and requirements thatthe design had to fulfill. There is alsosome brief background information aboutwhy a drum test is required for abicycle rim manufacturers and about thecompany Innolite Design AB that thisthesis is done for. After that itfollows an extract from conceptgeneration with the chosen concepts andsolutions but also some of the conceptsthat were not chosen.The thesis also contain a part where thereader cangain a deeper understanding of how thedesign works as well as some moredetailed facts about how the choice ofmaterials, their thicknesses, etc. havebeen made.

The current situation for Swedish grain farmers facing a situation with decreasing profitability makes it necessary for the farmers to find ways of increasing the margins in their grain growing. Decreasing profitabilities along with Lantmännens closing of grain elevators contribute to the necessity for farmers to invest in grain storing and drying at the farm. By investing in capacity for drying and storage of grain on the farm it is possible to recieve a higher price on the grain sold due to the possibility to sell when the price is higher compared to the harvesting season. An investment in grain drying and storage with a relatively low investment cost that recently has appeared on the Swedish market is the grain stir drying system. This study contains a comparison of an investment in a grain stir drying system where the grain is dried and stored in the same silo and a conventional drying and storage system.

Many corporations turn to IT-outsourcing to focus more on their core competence or to cut the IT-budget. There is one caveat, the costs presented at a first glance does not always present the entire truth. Instead the costs run deeper and so-called hidden costs exist beyond the contractual cost. Reducing these hidden costs may very well be crucial to the entire IT-outsourcing endeavor. However many firms are not aware of these costs and as such they have a reduced chance of success.

The objective of this study is to examine the sustainability of recovering industrial wasteheat from several heat sources in a foundry constructed in a plant belonging to ITT Waterand Wastewater in Emmaboda, Sweden. A triple bottom line perspective will be appliedto achieve this objective. The triple bottom line approach takes into account ecologicaland social performance in addition to financial performance. The technology forrecovering the waste heat is a Borehole Thermal Energy Storage (BTES) which is aconstruction consisting of 140 vertical boreholes, 150 meters deep with an internal spaceof four meters.The calculated amount of energy for storage is approximately 3800 MWh annually. Ofthis amount 2500 MWh are expected to be utilized, while storage losses accounts for theremaining part.

This is a final thesis done at BT, considering one of their forklift truck models called Reflex. The first part of this report is about a preliminary investigation investigating what kind of diagnostic systems BTwants to use, and also which demands there are to meet all expectations on such system. Secondly a diagnostic system, which will show if the drive wheel is worn out, will be presented. In the preliminary investigation, two kinds of diagnostic systems were mentioned. These were Model based diagnosis and Predictive analysis.

Future emission legislation puts great emphasis on increasing the efficiency of the engine, thereby reducing fuel consumption. The tribological contact between cylinder liner and piston ring is where an great amount of energy is lost due to friction, and by reducing these losses an reduction in fuel consumption can be achieved.The aim of this thesis was to evaluate the tested piston ring coatings against a plasma sprayed cylinder liner and rank these combinations of materials for friction and wear resistance. The coatings that were tested was Cr + Al2O3, (Al,Cr)N, two types of CrN and WC / C.The experimental tests were performed with a so-called pin-plate, where used oil with addition of an acidic mixture of sulfuric and nitric acid to mimic the acidic condensate formed when exhausts recirculate, were added with a continuous flow. The results were then analyzed by weighing, studies by optical microscopy and scanning electron microscopy (SEM) and profile measurements.The results from each material combination were that the plasma coated cylinder liner wears too aggressively in order to yield a ranking of the piston ring coatings based on the parameters of friction and wear resistance. It is therefore proposed that an alternative coating on the cylinder liner should be developed, lacking the large abrasive wear on piston rings and that can withstand the corrosive environment resulting in engines equipped with EGR.

SEP Modular Armoured Tactical System is the next generation of military vehicles developedby BAE Systems Hägglunds AB. At present time, BAE Systems Hägglunds AB aredeveloping a 6-wheel electrical hybrid and a conventional 8-wheel vehicle. The questionformulation was summarized as: ?In which ways can the electrical transmission in a hybriddriveline for SEP be designed, when the surrounding fixed interfaces are kept and the unity ofcomponents within SEP is maximized??. The purpose of this master thesis was to study avariety of concepts for hybrid propulsion.

The Swedish bank Handelsbanken has, according to their own way of measuring, been more successful than a weighted average of their competitors during the last 38 years. They have also handled the recent financial crisis, as well as the one in the 1990´s, better than most other banks. This paper studies their management control system at branch level in order to identify the controls which have been enforced to ensure that a low risk level is retained in the lending. The controls that have been identified are; (1) A decentralized organization with the offices as profit centers where the manager has restrictions regarding risk level and the results are measured as K/I (cost/revenue). (2) The absence of bonuses and individual follow-up regarding performance measurement.

The Smart Grid technology has during the last decade been established as a way to create a greater flexibility on the electricity grid that will be needed as the development moves towards an increased share of renewable primary energy sources in the electricity production. One part of the Smart Grid technology is the ability to shift loads in time, to adapt to either price or emissions, known as Demand Response. This project, which was conducted at KTH in collaboration with the consulting corporation Capgemini, examines the economic, environmental and social aspects of the Demand Response technology. In the project, three household products are used in a model that derives the potential savings in costs and emissions of CO2e. The results show that the actual savings measured in SEK are small, but that the savings measured in percent can be as high as 20 percent. Reduction of CO2e emissions is slightly lower.

Sigill Quality Systems has been certifying beef since the autumn of 2006 using the brand name label Swedish Sigill. IP Sigill (the certifying system for integrated production) encompasses the values: animal ethics, food safety, free range and environmental concerns. Product quality is not yet one of these values, and there is a variation in the quality of Swedish beef. Swedish Sigill wanted to investigate the factors that influence product quality, review which of the present regulations that have an influence on product quality and formulate new regulations with the purpose of enhancing the product quality (sensorial, technological and nutritional quality). A survey of quality parameters and factors that influence product quality was done in order to establish a scientific foundation to work from.

Detta arbete presenterar enmatematisk optimeringsmodell gällande val av Prefableverantör för Spinactor ABmed avseende på inköpspris med volymrabatt samt transportkostnad. Utöver dettatillkommer en kvalitativ undersökning om vilka andra kriterier som ärbetydelsefulla vid leverantörsavtal. De viktigaste kriterier applicerades i enegenutvecklad leverantörsvalsmodell som bygger på ramverket ?total cost of ownership?(TCO) där leverantörskriterierna kvantifieras. Utifrån kriterieanalysenframgick att de tre viktigare leverantörskriterierna för Spinactor AB idagsläget är leveransprecision, kundservice och kommunikation samt ekonomiskstabilitet.Lösningen av optimeringsproblemet genomfördes med två olika metoder,linjärprogrammering samt heltalsprogrammering, där linjärprogrammering vardominerande i lösningstid.

Radio Frequency Identification, RFID, is a convenient way to enable contactless identification which does not require any physical nor optical contact. As with any radio-based communication the signal can be intercepted, thus making the technology vulnerable to several kinds of attacks. Interception of communication is not the only threat. Since RFID tags might contain personal information or information that will grant the owner access to secure areas, skimming and spoofing attacks are also major threats against this technology. In this thesis report,  the perspective of an adversary is portrayed in an RFID-enabled environment by presenting where RFID is used and how it could be abused.

This report shows methods and workflow when exploring the potential to change Outotecs HCD Silver Electrolysis machine to a module type. It?s done as an attempt to lower the workshop and installation costs and to give customer a more accurate prize directly. To do this a concept was produced which was set to a stress test. Additional objectives were to investigate freight and installation procedures, pneumatic connections and to calculate the difference in cost.Once the concept, a reinforced type of the original frame, was chosen stress tests in computer simulations were made and appropriate alterations were made.