Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Trans fatty acids from ruminants - and its effect on blood lipidprofile in healthy men and womenAuthor: Sophie Berg and Sara KarlssonSupervisor: Henriette PhilipsonExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 23, 2012BackgroundCardiovascular disease is the most common cause of death in Sweden. It is well known that thereis a link between high consumption of industrial trans fatty acids and cardiovascular disease, buthow natural trans fatty acids affect us remains uncertain.ObjectiveThe purpose of this article is to, based on the currently available scientific evidence, concludewhether an intake of trans fatty acids from ruminants generates an effect on the bloodlipid profile of healthy men and women.Search strategyRCT articles were obtained through searches in databases such as PubMed, The CochraneLibrary, and Scopus. Keywords used were "ruminants" AND "Cholesterol" AND "Trans FattyAcids" and "ruminants" AND "Blood Lipids" AND "Trans Fatty Acids".Selection criteriaInclusion criteria were RCT studies conducted on healthy people who did not receive medicationfor hyperlipidemia. Moreover, the results were to be based on fasting blood samples, where atleast ten hours of fasting preceded the analysis of the blood lipids.Data collection and analysisThe search generated eight studies. These were graded according to SBU:s Granskningsmall förrandomiserad kontrollerad prövning, after which four studies were selected.

Today most dosages used in horse medicine are based on studies in adult horses. Since there are differences between adult and neonatal horses with respect to different pharmacological parameters this can cause problems when administring drugs to neonatal foals. Neonatal sepsis is a common cause of morbidity and mortality in foals and aggressive antibiotic treatment is needed immediately when sepsis is suspected. In Sweden the combination of trimethoprim/sulphadiazine and bensylpenicillin is often used as the initial treatment. When administering drugs, interactions can occur between the drugs and endogenous substances.

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical NutritionTitle: ?What nutrition therapy has the best outcome on growth in preterm children and/or children born with low birth weight??Author: Josefine Nyström and Rebecca HammarSupervisor: Fredrik BertzExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 11, 2013Background: There is a number of reasons why a child is born preterm and with a low birth weight, for instance if the mother is underweight, smoking or exposed for malaria. The negative consequences of being born preterm or with a low birth weigth are many, both on long and short term. According to the WHO preterm birth is the most common direct cause of infant mortality. By providing the right measures in time when it comes to nutrition the mortality can be reduced considerably.Objective: To examine and summarise the scientific ground when it comes to the best nutrition therapy for preterm children and children born with a low birth weight.Search strategy: A systematic literature search was done in the databases Pubmed, Cohrane and Scopus.

Handling of animals during anaesthesia is an important field in the profession as a veterinary nurse and in which intubation is an essential part. Hence, adequate knowledge is necessary for the welfare of the animal. The objective of this literature study was to make it useful and trustworthy for veterinary nurses. It is intended to describe and summarize existing scientificity with its benefits and disadvantages within the different areas of intubation techniques and alternative methods of inhalation anaesthetic supplementation for general anaesthesia in rabbits. Endotracheal intubation in rabbits can be complicated and technically demanding due to the anatomy of the oropharynx including the narrowness of this structure, a relatively large tongue, large incisors and a limited mobility of the temperomandibular joint. The obstructed visualization of larynx and the rabbit?s tendency to develop laryngospasm contributes to the difficulty of intubation. Rabbits are susceptible to tracheal injury and multiple intubation attempts can cause tracheal lesions due to repeated damage to the tracheal mucous membrane, although damage can occur after a single intubation attempt as well. An ETT (endotracheal tube) with or without a cuff can be used during orotracheal intubation in rabbits.

Bakgrund: Från växtriket och örten Artemisia annua har antimalarialäkemedlen artemisinin och dess derivat kunnat framställas. Många rankar dessa läkemedel som de effektivaste vapnen som finns i kampen mot malaria idag. Malaria är en sjukdom som varje år skördar en miljon människors liv och orsakar stort lidande för oerhört många människor. Syftet med detta arbete är att besvara frågan hur effektiva artemisinin och dess derivat är vid okomplicerad falciparum malaria samt att belysa problematiken som behandling med artemisininer kan tänkas innebära vad gäller resistens och förekomst av falska läkemedelskopior.Metoder: Projektet utgjordes av en litteraturstudie där forskning som utvärderar effekt av olika antimalarialäkemedel studerades. Utvärderingen av effekten och studieupplägget skulle vara enligt WHO:s riktlinjer och effektmåttet ACPR (adequate clinical and parasitological response), vilket innebär andelen patienter som var botade både kliniskt och parasitologiskt efter en uppföljning på 28 dagar.

SammanfattningBakgrunden beskriver hur barnmorskans arbete ska byggas på vetenskap och beprövad erfarenhet enligt gällande författningar, förordningar, föreskrifter och andra riktlinjer. Det åligger därför barnmorskan att kunna söka, analysera och kritiskt granska relevant kunskap för att kunna delta i utvecklingsarbete eller dess utvärdering. Det finns ett värde i att reflektera över befintliga rutiner och vid behov medverka till en förändring samt implementera ny kunskap. Kliniska riktlinjer har tagits fram för att underlätta det kliniska arbetet och det är därför viktigt att riktlinjerna innehåller evidensbaserad forskning. Syftet med studien var att granska och värdera kvaliteten av lokala behandlingsriktlinjer gällande mödrahälsovårdens basprogram.

Subclinical mastitis (SCM) is a well-known problem in the dairy sector, where it causes severe economic losses mainly due to reduced milk production. This is a problem not only in the western world but also in developing countries. Surveys from different developing countries have shown a SCM prevalence of 52.4 ? 88.6 % at cow level and 26.7 ? 63.2 % at quarter-level. To combat mastitis is important to optimize the milk production of the cow.

Equine metabolic syndrome (EMS) it?s a clinical condition that includes obesity, regional adiposity, insulin resistance (IR) and laminitis. A similar syndrome exists in human medi-cine, the metabolic syndrome (MS), were systemic hypertension also is a prominent fea-ture. The systemic hypertension seen in humans with MS is partly due to a vascular endo-thelial dysfunction with an enhanced endothelin-1 (ET-1) mediated vasoconstriction. There are indications that systemic hypertension might be a feature in EMS as well but if ET-1 is involved in the development of the systemic hypertension in horses is not known.

ABSTRAKTSyfte och mål: Att jämföra olika tekniker vid trakeal intubering av obesa patienter. Bakgrund: Fetma blir vanligare och behovet av kunskap inom vården ökar för att på ett säkert sätt ta hand om dessa patientgrupper. Anestesisjuksköterskan ska kunna hantera, prioritera och ta snabba beslut vid akuta tillstånd och förebygga komplikationer som kan uppstå. Kunskap och beredskap inför akuta situationer är av stor vikt för att hantera den svåra luftvägen och kunna ge en god och säker omvårdnad genom anestesin.                                                                   Design: En litteraturstudie med kvantitativ ansats genomfördes.

The incidence of many of the most common diseases in dairy cattle has been proven to be highest during the time closest to calving. It is possible that the current breeding strategy with 12 month calving intervals increases the risk for disease in dairy cattle, which is problematic concerning both animal welfare and for economic reasons. The economic incentives behind a calving interval of 12 to 13 months have mainly been based on milk- and feed- costs and no costs due to diseases or fertility disturbances have been included.The aim of this study was to see if a lengthening of the calving interval would result in lower disease frequency. The hypothesis is that cows with a planned calving interval of 15 months have a lower disease incidence than cows with a calving interval of 12 months due to less number of calvings. Therefore the difference in disease frequency should be larger when compared over a long period of time, such as over lifetime, since cows with a longer calving interval experience fewer calvings.The study was performed between August 17th, 1994, and January 24th, 2007.

AbstractTitle: The debut of gluten ? Does timing of gluten introduction affect the risk ofceliac disease in high-risk children?Author: Sandra Hagwall Frohm and Maria IngmarSupervisor: Frode SlindeExaminer: Mette AxelsenProgramme: Programme in dietetics, 180/240 ECTSType of paper: Bachelor?s thesis in clinical nutrition, 15 hpDate: May 26, 2015Background: Celiac disease is a chronic disease in which the intestinal mucosa is damaged bygluten exposure, and the only treatment is a lifelong gluten-free diet. The disease affects about1 % of the population worldwide, but the majority are undiagnosed. Ingestion of gluten and thegenotype HLA-DQ2/8 are required for disease development, although additional genetic andenvironmental factors are believed to be of importance. One hypothesis is that timing of glutenintroduction in infants affects the disease risk.

Atopic dermatitis (AD) is a complex, often lifelong allergic disease affecting around 10 % of both dogs and humans. The hallmark symptom is severe pruritus, causing a lowered quality of life. Mast cells (MCs) are known to play an important part of the immunopathogenesis, promoting a faulty T helper cell type 2 (Th-2) response which follows by a production of specific immunoglobulin E (IgE) antibodies towards environmental allergens (Ag). To further investigate the role of MCs and its mediators in the progression of AD, a low-calcemic vitamin D3 analog (MC903) was used to induce AD-like symptoms locally on the ears of two different knock-out (KO) mouse strains. The first strain was Wsh-/- mice deficient in MCs.

Diabetes mellitus is a rising epidemic throughout the world and there is currently great interest in quantifying the beta-cell mass (BCM) in vivo non-invasively. In the present experiment, the feasibility of in vivo imaging of the glucagon-like peptide-1 receptor (GLP-1R) in beta-cells was examined, using the positron emission tomography (PET) tracer [68Ga]Ga-DO3A-VS-Cys40-exendin-4 as a marker, in native pancreatic beta-cells of a porcine diabetic animal model and healthy controls. Eight Swedish high-health domestic pigs were randomly assigned to be either controls or made diabetic using streptozotocin (STZ). The experiment proceeded during eight weeks, starting with an acclimatisation period. Once the pigs had been socialised they underwent surgery for the insertion of a jugular vein catheter, allowing induction of diabetes with STZ, intravenous (i.v.) injections and stress-free blood sampling. Development of diabetes was confirmed by clinical examinations, blood glucose values and insulin-staining of pancreatic sections post mortem. The diabetic pigs were insulin treated and responded well.

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical Nutrition3AbstractTitle: How does isoflavones in combination with soy protein impact cholesterol levels in hypercholesterolemic postmenopausal women relative to milk protein?Author: Emma Edberg och Emma NilssonSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician stydy programme,180/240 hpType of paper: Examination paper, 15 hpDate: 2014-05-26Background: Hypercholesterolemia is a major risk factor for cardiovascular disease and the number one cause of death among women in Western countries. Declining levels of estrogen at menopause could be a contribution factor. Isoflavones is a vegetable substance, with structural and functional similarities to the human estrogen. This is a potential reason for possible cholesterol-lowering effects.

The first two weeks in a pup's life is called the neonatal period. This period is dominated by growth and development of organs and senses. The puppy is born blind and deaf and the physiological disability makes it unable to move properly. The neonatal period is characterized by a lot of sleeping. The pup receives the important milk and warmth from the bitch.