Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

The common literature about strategic alliances offers a very fragmented picture. This thesis gives a theoretical overview on strategic alliances and builds the basis for the following examination of the different dimensions most strategic alliances have. The examination of the different dimensions is the crucial point of this thesis. Here the reader gets a detailed insight into the different dimensions and the implications they have on the design of a particular strategic alliance. This examination leads in the end to a more differentiated view on strategic alliances and the insight that no simple models exist, which give a sufficient basis for decision-making and understanding strategic alliances, today.

Featured adjuvant chemotherapy treatment in women with breast cancer can lead to pain. The aim of this study was to explore, the variety of perceptions and impact of adjuvantchemotherapy-induced pain in daily life, of some women newly diagnosed with breast cancer.Inclusion criteria were participating in an ongoing stress management projectand chemotherapy of (anthracycline/taxan) in doses of 75mg² or more. Exclusioncriteria were inability to understand and communicate in Swedish and mentalillness. After ethical approval of the sub study in September 2010, women wereconsecutively included through oral and written request. Phenomenologicalapproach was used in the eight interviews and data analysis.

The common literature about strategic alliances offers a very fragmented picture. This thesis gives a theoretical overview on strategic alliances and builds the basis for the following examination of the different dimensions most strategic alliances have. The examination of the different dimensions is the crucial point of this thesis. Here the reader gets a detailed insight into the different dimensions and the implications they have on the design of a particular strategic alliance. This examination leads in the end to a more differentiated view on strategic alliances and the insight that no simple models exist, which give a sufficient basis for decision-making and understanding strategic alliances, today.

The county of Dalarna is at present carrying through a process of digitalization where traditional x-ray film is being replaced with digital detectors. Earlier used methods for dose optimization turned out not being sufficient. This report presents a method to harmonize dose levels between x- ray sites equipped with Fujifilm imaging plate systems. An exposure index, S, related to the dose level of the examination is computed to every x-ray image. S turned out to be inversely proportional to the detector dose used at the examination.

This report presents a thesis project conducted by two students at Mälardalens högskola. The project covers 15 points in industrial design and was conducted during April to June 2014. The principal of the thesis works at Plastic Produkter. The assignment was to develop equipment for an effective way to dose, mix silicon, fill a special designed plastic bag and then seal it. The bag is then formed into a breast model.When a customer for various reasons decides to do a breast augmentation or a breast reconstruction, there may be doubt or uncertainty about the result.

The county hospital of Dalarna has for the last couple of years carried through a process of digitalization. The result is that within the county it exists image plate systems from two different manufacturers. In an attempt to create a tool for dose optimization and dose surveillance the county of Dalarna would like to investigate if the exposure index from Agfa and Fuji is suitable as a dose indicator. An investigation of the exposure index, S, from Fuji has already been done. This thesis has been continuing the investigation by evaluating the stability of the exposure index, lgM, from Agfa.

Sammanfattning Denna studie redovisar resultatet av en kvalitativ intervjuundersökning angående muntlig examination inom vuxenutbildningen. Syftet med studien var att undersöka användandet av muntlig examination vid slutprov av kurser inom den gymnasiala och grundläggande vuxenutbildningens Omvårdnadsprogram och Barn- och fritidsprogram. Intervjuerna genomfördes vid tre skolor där sammanlagt nio personer intervjuades. En skolledare och två lärare intervjuades vid respektive skola. Intervjumaterialet bearbetades genom två kategoriseringar.

In the report parasites in the gastrointestinal tract and easily visible external symptoms of disease in capercaillie, (Tetrao urogallus), was taken into account. The study was based on results from the examination of 62 fresh faecal samples, collected in spring 2003, and postmortem examination of 22 frozen birds that were collected between 1999 and 2003. All of the samples principally were from the north of Sweden. In total, 4 species of parasites, but no significant symptoms of disease were found. In the faeces low levels eggs of the roundworms Capillaria spp. (125 epg) and Ascaridia spp.

Bakgrund: Övervikt och fetma är en global epidemi. Fetma kan orsakas av arv, miljö och beteendemässiga faktorer. Övervikt kanleda till flera följdsjukdomar. Viktminskning kan ge ökad livskvalité pch psykiskt välbefinnande. Ur ett hälsoekonomiskt perspektiv är det av vikt att det hälsofrämjande arbetet startar tidigt i barndomen.

The purpose of this study was to develop two types of prediction models for Scots Pine and Norway Spruce. The first type for calculation of the stump diameter under bark the year the tree reached breast height (Dstubh130). The second type for calculation of the annual difference, e.g. the number of growth years between stump height (0.2 m) and breast height (1.3 meters above ground level). The primary thought with these prediction models is to obtain the breast height age in the trees on basis of the number of annual rings at stump.

Bakgrund: Bröstcancer är en sjukdom som drabbar allt fler kvinnor världen över, men samtidigt minskar antalet dödsfall på grund av säkrare diagnostiska metoder och behandlingsmöjligheter. Utöver konventionell mammografi har MR-mammografi vuxit fram och är idag en etablerad metod inom bröstcancerdiagnostiken. Syfte: Syftet är att belysa MR-mammografins betydelse för kvinnor som undersöks i avseende att utesluta eller upptäcka bröstcancer. Metod: Examensarbetet genomfördes i form av en litteraturöversikt där forskningsmaterial ur vetenskapliga artiklar granskades och sammanställdes. Resultat: Kvinnor med förhöjd bröstcancerrisk gynnas av att genomgå MR-mammografi.

This examination work is about an marketing investigation of John Deere Moco 730/735 during the season year 2003. Moco 730 has an workingwidth on 3 m, and 735 has one with 3,5 m. The research results of 16 moco 730/735 are from intervju- and questionnaire made of the owners. The results also comes from intervju anwser from dealers which sold this mocos. The examination work shows comments and opinions from the customer after one seasons use. In the end of my examination work are all comments and opinions put together in a marketing analysis called swot-analys in Swedish. The analysis declare that the moco 730/735 is functional and have god quality. The future seems god for this kind of moco. The strength for this moco are god quality and the dealers god service support. The most important weakness about this moco are that the machine came out late on the market, compared to other mocos on the market. I think it´s important the have in mind that the customers are very John Deere faithful and this JD 730/735 is used for only one season..

AbstractGrowing up with a functionally disabled sibling can bring joy and positive experiences, but also complications. The purpose of this paper is to describe the experience of growing up with a functionally disabled sibling. I have chosen to focus the examination on how individuals with functionally disabled siblings believe they have been affected by their relationship to their functional disabled sibling and whether it has continued to affect them in adulthood.The examination was qualitative and conducted through interviews. The results showed that siblings of functionally disabled individuals tend to grow up with strong feelings of responsibility and anxiety that continue to affect them into adulthood. The investigation further showed that all interviewed chose occupations in care, and that they give great attention to relationships to others.

Social support is an important part of handling the troubles of life. The purpose of this literature review is to investigate what forms the social support for adult women with breast cancer with the aim to be used in the nursing care. By system-atical reading of scientific articles nine qualitative articles were found which the result is based on. The theoretical framework was Antonovsky´s health focused theory with the central issue KASAM, the feeling of life connection. The study resulted in three themes emotional support, practical support and informational support, which describe the balanced content of social support.