High quality within a Lean production system begins with standardised work, which creates stable processes able to generate predictable output. If nonconformity from the standard procedures occurs, routines are needed to analyse, correct and prevent the nonconformity from occurring again. In that way, the nonconformity can be a trigger for continuous improvements toward more stable processes. In takted production lines, where the operator follows a standard sequence with tasks set to be completed within the takt time, a nonconformity leads to downtime in the operator?s sequence, and no value is added.

SammanfattningMykotoxiner är sekundära metaboliter som kan bildas av vissa mögelsvampar. Idisslare har generellt ett högre skydd mot mykotoxiner än vad enkelmagade djur har då våmmens mikroorganismer kan fungera som ett extra skydd mot mykotoxikos. Trichotecenerna deoxynivalenol och T-2 toxin bryts ner till de-epoxymetaboliter i våmmen genom att dess toxiska epoxyring spjälkas bort. Deoxynivalenol metaboliseras helt eller delvis av våmmens mikroorganismer, medan T-2 toxinets nedbrytningskapacitet inte är lika hög. Aflatoxin B1 har en låg nedbrytbarhet, och inga metaboliter har kunnat detekteras i våmmen.

The research in the field of biotechnology is rapidly developing all over the world. Modern biotechnology offers unique opportunities, simultaneously as it gives rise to a number of ethical issues. Preimplantation genetic diagnosis (PGD), PGD/HLA (Human Leucocyte Antigen) and germline gene therapy (GLGT) are controversial techniques. PGD gives a possibility to identify a genetic disease prior to the embryo?s implantation in the uterus.

Disinfection methods for drinking-water produced at the two water works of Stockholm Water Co are compared in this study. Three different nethods are compared; disinfection with chlorine gas, disinfection with sodium hypochlorite and disinfection with UV-light and monochloramine. The method used is Life cycle assessment, LCA. LCA is defined as the compilation and evaluation of the inputs, outputs and potential environmental impact of a product system shroughout its life cycle. The environmental burden is compared for the three different disinfection methods.

Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

Rotavirus causes diarrhea in young mammals all over the world, including infant humans. The diarrhea leads to severe dehydration that can be fatal if left untreated. The dehydration can be treated with fluid therapy and the infection heals itself. Despite the relatively easy treatment half a million children under the age of five dies every year due to diarrhea caused by rotavirus. Rotavirus sorts into the family Reoviridae and is a double-stranded RNA virus with a segmented genome.

Cats and dogs are often unattended by their owners both indoors and outdoors, and therefore there is always a risk that they will get hurt. In the past, poisoning cases was considered unusual, but nowadays they are considered more common. As a veterinary nurse, it is important to know the common symptoms of poisoning, especially when working with emergency veterinary care. A very essential part of the profession as a veterinary nurse is to inform pet owners about the potentially dangerous substances and how poisonings can be prevented. The purpose of this report was to find out what is written scientifically about some common poisonings in dogs and cats and to present available statistics that covers the number of animals poisoned by various substances in Sweden. Hopefully this essay can also be used as a handbook for professionals in animal health care and to assist in educating pet owners. The report mainly covers groceries found in many homes, often easy accessible.

Rotavirus causes diarrhea in young mammals all over the world, including infant humans. The diarrhea leads to severe dehydration that can be fatal if left untreated. The dehydration can be treated with fluid therapy and the infection heals itself. Despite the relatively easy treatment half a million children under the age of five dies every year due to diarrhea caused by rotavirus. Rotavirus sorts into the family Reoviridae and is a double-stranded RNA virus with a segmented genome.

Pyometra is a common and life threatening disease of intact bitches. The disease is caused by a hormonal influence on the uterus in combination with a bacterial infection. The most common treatment is ovariohysterectomy, but several medical options are available to maintain fertility or avoid surgery and anaesthesia. Drugs that can be used for medical treatment are for example progesterone-receptor antagonists, prostaglandins and dopamine agonist. The present study focused on treatment with the progesterone-receptor antagonistaglepristone in combination with antimicrobial therapy.

System based models of plants rely on descriptions and assigned functions of genes, and currently 50% of the genes in Arabidopsis thaliana has either no assigned function or a function based on homology only. Mitogen activated protein kinases (MAPK's) are key players in cell signalling and are conserved among eukaryotes, though their targets are highly diverse. A recent study has described a small Arabidopsis protein (80), without homology to any described protein, as a phosphorylation target of the MAPK's MPK3/6. Further work established ?-glucan phosphorylase (PHS) as interacting with 80 and described a delayed senescence phenotype for 80 knock-out plants.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.

Hästar riskerar att drabbas av endotoxinemi framförallt vid olika typer av kolik men även vid andra sjukdomstillstånd. Stressen och inflammationen som uppstår vid endotoxinemi, liksom vid vissa andra typer av akuta skador eller allvarliga sjukdomstillstånd, kan leda till utvecklandet av insulinresistens, glukosintolerans och hyperglykemi. Dessa metaboliska rubbningar är i sig skadliga och inom humanvården behandlas intensivvårdspatienter vid behov med insulin för att förbättra tillfrisknande och överlevnad.För att inhämta mer kunskap om de metaboliska rubbningarna, som sker hos hästar med endotoxinemi gjorde vi en prospektiv experimentell försöksstudie av hästar som infunderades med endotoxin och provtogs för analys av serumglukos och plasmainsulin. De 8 hästarna som användes i försöket infunderades med Escherichia coli endotoxin (SigmaAlderich L5418, O55:B5) i en total dos på 500 ng/kg kroppsvikt under 6 timmar. Provtagning och analys av glukos och insulin skedde från och med ett dygn innan endotoxininfusionen och upp till 36 timmar efter dess start.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

Broad beans are becoming a larger crop in Sweden. This is probably due to the current discussion about the cultivation of soya beans that are imported to be used as protein fodder. Broad beans are a good break crop in a small grain intensive crop rotation and works as a protein source for animals together with for example ley. At present little research has been done on broad beans and more knowledge is needed. This study is about fungal communities and diseases on broad beans and the impact of these fungi on seed germination.