Bakgrund: I Sverige är det mer än 160 000 personer som insjuknat i demens och hälften av dem har Alzheimers sjukdom, som är den vanligaste demenssjukdomen. När diagnosen Alzheimers sjukdom ställts förändras patientens och anhörigas livssituation. Anhöriga tar på sig ett ökat omvårdnadsansvar och känner en större ängslan och oro för framtiden. Syfte: Att belysa anhörigas upplevelser av att vårda en person med Alzheimers sjukdom. Metod: Studien utfördes som en allmän litteraturstudie och sju vetenskapliga artiklar som motsvarade syftet granskades kritiskt och analyserades.

Bakgrund: Sjukdomen schizofreni innefattas av symtom såsom vanföreställningar, vrede och apati samt har en hög självmordsprevalens. Närstående får ofta en minskad livskvalitet pga. de stora påfrestningar de utsätts för. De behöver stöd från vården för att orka vara delaktiga i den sjukes liv. Syfte: Att beskriva upplevelser av att vara närstående till en person som har schizofreni och på så vis öka sjuksköterskans förståelse för denna individgrupp.

The focus of this project was to characterize the occurrence of ESBL-­?producing bacteria in two irrigation water ponds in Southern Sweden. Samples were taken from two ponds nearby each other, from which analyses were made based on levels of community and individual isolates. Community samples were used for attempts for characterization of resistance patterns in irrigation water using the Omnilog PM-­?plate system. The growth of community microbiota in the presence of the following antibiotic substances was assessed; amikacin, gentamicin, kanamycin, penicillin G, ampicillin, piperacillin, trimethoprim, potassium tellurite and ciprofloxacin. Isolates were pure cultured using semi-­?selective media: LB, Rainbow Agar, mEnterococcus, 0.1 TSA and VRBD. A total of 177 isolates were isolated randomly. Each isolate was identified using the Omnilog GENIII-­?system of biochemical characterization. Further, the isolates were tested on Brilliance ESBL-­?agar for their ability to grow. Out of the total number of isolates, 30 were selected, preferably Enterobacteriaceae or Pseudomonas spp., based on their high similarity to library strain during the identification in the Omnilog-­?system. These were further characterized using Etest-­?sticks. Three selected strains were picked for further analyses using exogenous isolation for attempts to simulate horizontal gene transfer, and Omnilog PM-­?panels containing various antibiotics of interest. Selections of samples were chosen for molecular tests targeting plasmid-­?borne resistance genes CTX-­?M1, CTX-­?M2 and SHV. The method for assessing community-­?resistance patterns showed ambiguous data that was difficult to interpret; further optimization is recommended. For all tested PM-­?plates, generally greatest differences between substances were found among wells with the strongest concentration of antibiotic substance. A total of 175 isolates displayed ability to grow on ESBL-­?agar. Etests confirmed ability of isolates to resist many ?-­?lactam antibiotics and many were clinically resistant to certain substances. No plasmids were transferred during exogenous isolation. During molecular tests, a few matches were found for the CTX-­?M1 gene. Isolates analyzed with Omnilog PM-­?plates showed resistance to most compounds tested. The isolates showed greatest resistance toward penicillin G, ampicillin, amikacin, kanamycin and trimethoprim. In the study, it was established that resistance among bacteria was frequently occurring in the irrigation water, and ?-­?lactamase producing bacteria was very common. Extended studies are needed to assess the frequency-­? and occurrence of horizontal gene transfer (HGF) in this environment. Although some potential corresponding data is found, it is at this point not possible to determine whether the resistances are due to antibiotics used in veterinary medicine, human medicine or one additional reason is travel and trade. in irrigation water using the Omnilog PM-­?plate system. The growth of community microbiota in the presence of the following antibiotic substances was assessed; amikacin, gentamicin, kanamycin, penicillin G, ampicillin, piperacillin, trimethoprim, potassium tellurite and ciprofloxacin. Isolates were pure cultured using semi-­?selective media: LB, Rainbow Agar, mEnterococcus, 0.1 TSA and VRBD. A total of 177 isolates were isolated randomly. Each isolate was identified using the Omnilog GENIII-­?system of biochemical characterization. Further, the isolates were tested on Brilliance ESBL-­?agar for their ability to grow. Out of the total number of isolates, 30 were selected, preferably Enterobacteriaceae or Pseudomonas spp., based on their high similarity to library strain during the identification in the Omnilog-­?system. These were further characterized using Etest-­?sticks. Three selected strains were picked for further analyses using exogenous isolation for attempts to simulate horizontal gene transfer, and Omnilog PM-­?panels containing various antibiotics of interest. Selections of samples were chosen for molecular tests targeting plasmid-­?borne resistance genes CTX-­?M1, CTX-­?M2 and SHV. The method for assessing community-­?resistance patterns showed ambiguous data that was difficult to interpret; further optimization is recommended. For all tested PM-­?plates, generally greatest differences between substances were found among wells with the strongest concentration of antibiotic substance. A total of 175 isolates displayed ability to grow on ESBL-­?agar. Etests confirmed ability of isolates to resist many ?-­?lactam antibiotics and many were clinically resistant to certain substances. No plasmids were transferred during exogenous isolation. During molecular tests, a few matches were found for the CTX-­?M1 gene. Isolates analyzed with Omnilog PM-­?plates showed resistance to most compounds tested. The isolates showed greatest resistance toward penicillin G, ampicillin, amikacin, kanamycin and trimethoprim. In the study, it was established that resistance among bacteria was frequently occurring in the irrigation water, and ?-­?lactamase producing bacteria was very common. Extended studies are needed to assess the frequency-­? and occurrence of horizontal gene transfer (HGF) in this environment. Although some potential corresponding data is found, it is at this point not possible to determine whether the resistances are due to antibiotics used in veterinary medicine, human medicine or one additional reason is travel and trade..

The purpose of this thesis is to investigate the fatigue life of two components in different hydraulic quick couplings. The crack which initiates the fatigue failure usually occurs in the bottom of one of the threads. Thus, the threads in the coupling are carefully investigated. A few different approaches for determining the fatigue life are studied for each component. CAD (Computer Aided Design) models for both components are created and analyzed with FEM (Finite Element Method).

Aim: The aim of this study was to investigate how women who have incurred ACL injury for more than 10 years ago, feel that the injury affects them today.Method: A qualitative semi-structured interview survey with five women who 10- 28 years ago incurred the anterior cruciate ligament injuries when playing handball or soccer has been performed. The study has been inspired by a phenomenological concept of science, mainly by life-world concept. Data were analyzed using qualitative content analysis.Main result: Some informants have experienced severe loss of physical ability in both daily living situations and in training, while others did not appreciably felt impacted in daily living and experienced great opportunities for physical activity. Limitations which emerged were restrictions in movement, joint stiffness, pain, swelling, and crepitations that led to the loss of physical ability. One respondent had been diagnosed with advanced osteoarthritis.

Iron deficiency is one of the most frequent micronutrient deficiencies around the world. Low iron bioavailability simultaneously with a high iron requirement is a high risk factor for developing iron deficiency. Probiotics are microorganisms that confer a health benefit on the host. Prebiotics are oligosaccharides which provide a health benefit on the host due to a positive modulation of the microflora in the gut. The aim of this paper is to evaluate if there is a connection between pro-and/or prebiotics and iron bioavailability.

From embankment dams is something that has long been noticed and given rise to different questions. The most serious question is if the sludge is a result of inner erosion through the dam, and thus consists of material transported from the dam. Concerns have also been raised whether the sludge could interfere with the systems drainage capacity and thereby lead to high pore pressure in the dam, or if the measurement of seepage is disturbed, as the measuring is usually made via Thomson weirs, which could risk being blocked. The result of this investigation shows that the sludge is a result of the oxidation of iron by iron bacteria, and to the greater part consists of these oxides as well as the bacteria?s own structures. The iron oxidizing bacteria, FeOB, oxides ferrous iron to ferric as a part of their metabolism, and thereby create large quantities of iron(oxy)hydroxides.

Today the individual ventilated cage system (IVC-system) is the most commonly used system when housing rodents. IVC systems are designed to control both supply and exhausted air at cage level, as well as temperature and relative humidity in the cages. This creates an optimal environment for the mouse and at the same time a protection against the risk of cross-infection between cages and the outside environment. The aim of this study was to evaluate the health and welfare for two different strains of laboratory mice (NMRI nude mice and C57BL/6NCrl mice) in three different kinds of IVC-systems; Arrowmight, Allentown and Tecniplast. 108 mouse pups from each strain (in total 216 mice) were selected after weaning at an age of three weeks and tested during 5 weeks.

Bovine viral diarrhoea virus (BVDV) is the causative agent of a complex of disease syndromes in cattle with high economical and welfare impacts. BVDV occurs as two biotypes; cytopathic (BVDVcp) and noncytopathic (BVDVncp) determined by differential effects on cultured cells and can also be divided into two genotypes (BVDV1 and BVDV2) on the basis of genomic diversity. The interaction between BVDV and the host?s immune system is regarded a key aspect in the sequel of BVDV infection. Infection with BVDV normally causes an acute transient infection, with mild to subclinical signs, but occasionally results in severe and even fatal disease.

The Swedish dairy production today consists of big farms and different housing systems are in use. These systems put demands on the cows? ability to cope with the environment and one challenge is the claw health in the herds. Some claw lesions that are frequently observed are foot rot, hemorrhages, digital dermatitis and sole ulcers, which can be caused by, for example, the claws? environment and the flooring type used.

Rapid urbanisation is putting strains on both the landscape and the city dwellers and the pressure on planning for sustainable and equitable cities is crucial. As many cities in Sub-Saharan Africa are expanding, city planning has trouble keeping up to meet the needs of the growing amount of urban dwellers. Many cities have also been planned with the cars in focus and the needs and comfort of the pedestrians have been overlooked. The capacity of institutions is limited due to centralized government and bureaucracy, as well as corruption. Planning is erratically implemented and it is difficult to know what will happen.

Bakgrund: Fibromyalgi drabbar två till tre procent av befolkningen och är ett kroniskt smärttillstånd utan känd orsak. Majoriteten av dem som drabbas är kvinnor. Sjukdomen syns inte utanpå och det finns därför en risk att drabbade blir missförstådda av människor i sin omgivning och av sjukvårdspersonal. Syfte: Att med den här litteraturstudien beskriva hur kvinnor med fibromyalgi upplever sin livssituation. Metod: En litteraturstudie baserad på elva kvalitativa vetenskapliga artiklar.

Subclinical mastitis (SCM) is a well-known problem in the dairy sector, where it causes severe economic losses mainly due to reduced milk production. This is a problem not only in the western world but also in developing countries. Surveys from different developing countries have shown a SCM prevalence of 52.4 ? 88.6 % at cow level and 26.7 ? 63.2 % at quarter-level. To combat mastitis is important to optimize the milk production of the cow.

Atopic dermatitis (AD) is a complex, often lifelong allergic disease affecting around 10 % of both dogs and humans. The hallmark symptom is severe pruritus, causing a lowered quality of life. Mast cells (MCs) are known to play an important part of the immunopathogenesis, promoting a faulty T helper cell type 2 (Th-2) response which follows by a production of specific immunoglobulin E (IgE) antibodies towards environmental allergens (Ag). To further investigate the role of MCs and its mediators in the progression of AD, a low-calcemic vitamin D3 analog (MC903) was used to induce AD-like symptoms locally on the ears of two different knock-out (KO) mouse strains. The first strain was Wsh-/- mice deficient in MCs.

Porcine circovirus type 2 (PCV2) is a common virus present in most parts of the world. PCV2 has been pointed out as the major causative agent to post weaning multisystemic wasting syndrome (PMWS) that affects pigs after weaning. The clinical symptoms of PMWS are impaired growth, diarrhoea, respiratory problems and increased mortality. At autopsy enlarged lymph nodes with depletion of lymphocytes are commonly found. Since 1991 PMWS has spread all over the world and was first described among Swedish pigs in 2003. Although PCV2 is widespread, only some pigs develop PCV2-related diseases. Why this is and what other factors that are required in order for the disease to develop is yet unknown. The main theories involve other infections, for example PRRS, and management issues but also genetic differences between pigs and/or virus strains have been suggested.