Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

The objective of this study is to examine the sustainability of recovering industrial wasteheat from several heat sources in a foundry constructed in a plant belonging to ITT Waterand Wastewater in Emmaboda, Sweden. A triple bottom line perspective will be appliedto achieve this objective. The triple bottom line approach takes into account ecologicaland social performance in addition to financial performance. The technology forrecovering the waste heat is a Borehole Thermal Energy Storage (BTES) which is aconstruction consisting of 140 vertical boreholes, 150 meters deep with an internal spaceof four meters.The calculated amount of energy for storage is approximately 3800 MWh annually. Ofthis amount 2500 MWh are expected to be utilized, while storage losses accounts for theremaining part.

This is a final thesis done at BT, considering one of their forklift truck models called Reflex. The first part of this report is about a preliminary investigation investigating what kind of diagnostic systems BTwants to use, and also which demands there are to meet all expectations on such system. Secondly a diagnostic system, which will show if the drive wheel is worn out, will be presented. In the preliminary investigation, two kinds of diagnostic systems were mentioned. These were Model based diagnosis and Predictive analysis.

Future emission legislation puts great emphasis on increasing the efficiency of the engine, thereby reducing fuel consumption. The tribological contact between cylinder liner and piston ring is where an great amount of energy is lost due to friction, and by reducing these losses an reduction in fuel consumption can be achieved.The aim of this thesis was to evaluate the tested piston ring coatings against a plasma sprayed cylinder liner and rank these combinations of materials for friction and wear resistance. The coatings that were tested was Cr + Al2O3, (Al,Cr)N, two types of CrN and WC / C.The experimental tests were performed with a so-called pin-plate, where used oil with addition of an acidic mixture of sulfuric and nitric acid to mimic the acidic condensate formed when exhausts recirculate, were added with a continuous flow. The results were then analyzed by weighing, studies by optical microscopy and scanning electron microscopy (SEM) and profile measurements.The results from each material combination were that the plasma coated cylinder liner wears too aggressively in order to yield a ranking of the piston ring coatings based on the parameters of friction and wear resistance. It is therefore proposed that an alternative coating on the cylinder liner should be developed, lacking the large abrasive wear on piston rings and that can withstand the corrosive environment resulting in engines equipped with EGR.

SEP Modular Armoured Tactical System is the next generation of military vehicles developedby BAE Systems Hägglunds AB. At present time, BAE Systems Hägglunds AB aredeveloping a 6-wheel electrical hybrid and a conventional 8-wheel vehicle. The questionformulation was summarized as: ?In which ways can the electrical transmission in a hybriddriveline for SEP be designed, when the surrounding fixed interfaces are kept and the unity ofcomponents within SEP is maximized??. The purpose of this master thesis was to study avariety of concepts for hybrid propulsion.

The component workshop at Atlas Copco inTierp intends to reduce the costs inorder to increase their competitiveness.This thesis examines how the productionmanagement around cylinder washersshould be managed in a way that meetsthe customer needs. The customer to thecylinder washer is Atlas Copcos assemblydepartment in Tierp.The purpose of this thesis is to providean alternative way of managing theproduction. A chapter of theory is addedto give the reader an insight ofdifferent types of production managementsystems as well as the underlyingknowledge needed to get a better readingexperience. An introduction of kanbancan in theory help Atlas Copco in thedirection they strive. It should beclear how the purpose of this thesisaffects the cost for the componentworkshop and also how it relates to thecurrent production.

The Smart Grid technology has during the last decade been established as a way to create a greater flexibility on the electricity grid that will be needed as the development moves towards an increased share of renewable primary energy sources in the electricity production. One part of the Smart Grid technology is the ability to shift loads in time, to adapt to either price or emissions, known as Demand Response. This project, which was conducted at KTH in collaboration with the consulting corporation Capgemini, examines the economic, environmental and social aspects of the Demand Response technology. In the project, three household products are used in a model that derives the potential savings in costs and emissions of CO2e. The results show that the actual savings measured in SEK are small, but that the savings measured in percent can be as high as 20 percent. Reduction of CO2e emissions is slightly lower.

Joint injury (inflammation) or osteoarthritis is the most common cause of poor performance in the athletic horse. Osteoarthritis is the ensuing degeneration of joint cartilage due to inflammation/injury. The single most important factor in the inflammation cascade of joint injuries is interleukin-1 (IL-1). Until recently, these injuries have been treated with products like hyaluronic acid, cortisone and polysulphated glycosaminoglycans (PSGAG). Several studies have not been able to demonstrate a significant difference in the clinical improvement of joint injuries treated with hyaluronic acid or PSGAG and saline.

Swedish horse breeders have generally very few mares producing a few foals a year and the breeders have relatively few traditions, little knowledge and experience to breed foals successfully. It is therefore important to provide adequate information about new findings in horse nutrition. However, there is not much research about feeding the suckling foal to ensure a sound growth. Current feeding recommendations in the literature seems to be different. This gives a confusing message and the information is difficult to apply. This paper reviews some publications in the area of feeding the suckling and weaning foal. Most authors stress that it?s important to start feeding the foal early in life.

Syftet med litteraturstudien är att utforska hur sjukhusmiljön påverkar patienter inom sluten somatisk vård. Med sjukhusmiljö avsågs utformningen och designen av sjukhusmiljön och miljömässiga faktorer/komponenter i denna. Metoden för utförandet av litteraturstudien har inspirerats av Goodmans modell. Urvalet bestod av 13 empiriska vetenskapliga artiklar som granskats och analyserats. Resultaten som funnits berör musik, ljus, ljud, akustik, patientrum, enkelrum/delade patientrum, patientsäng, sängplats, privat utrymme, avdelningens utformning, fönster och bekvämligheter/hjälpmedel.

This master?s paper first presents some of the principal theories and concepts developed by the poverty researchers Rowntree, Titmuss, Townsend, Sen and Lister. These theoretical frameworks are then related to two documents from the EU and Sweden concerning combating poverty and social exclusion, bearing on the establishment of the ?Year 2010 against Poverty?. Finally, I discuss the value in practice of these theories and policy documents, as regards reducing poverty in Europe.It has become clear in this investigation that the theories and concepts from earlier research are still relevant to the formulation of contemporary policy programmes, and that earlier research helps us to avoid old traps in fighting poverty.

The Smart Grid technology has during the last decade been established as a way to create a greater flexibility on the electricity grid that will be needed as the development moves towards an increased share of renewable primary energy sources in the electricity production. One part of the Smart Grid technology is the ability to shift loads in time, to adapt to either price or emissions, known as Demand Response. This project, which was conducted at KTH in collaboration with the consulting corporation Capgemini, examines the economic, environmental and social aspects of the Demand Response technology. In the project, three household products are used in a model that derives the potential savings in costs and emissions of CO2e. The results show that the actual savings measured in SEK are small, but that the savings measured in percent can be as high as 20 percent. Reduction of CO2e emissions is slightly lower.

När den svenska regeringen beslöt sig för att sänka restaurangmomsen den 1 januari 2012, gjordes det för att stimulera restaurangbranschen att sänka priserna på måltiderna, nyanställa och eliminera svartjobb. Vid en sänkning av momsen frigörs kapital, ett extra ekonomiskt utrymme, som för företagen blir en tillgång som de själva får avgöra hur det kommer disponeras.Denna studie ämnar ta reda på vilka effekter momssänkningen kommer medföra för branschen och hur restaurangägarna disponerat det ekonomiska utrymmet. Material har införskaffats genom en enkätundersökning med restaurangägare, intervjuer med hotell- och restaurangfacket samt branschorganisationen Visita. Med utgångspunkter bland annat inom nationalekonomiska teorier visar undersökningen att restaurangägare valt att använda det ekonomiska utrymmet till att nyanställa, sänka sina priser, genomföra renoveringar eller till överlevnadsmarginaler. Detta tyder på att det finns en spridning över hur restaurangägarna handlat.

Internet's entry into our home has changed our communication capabilities. As a result more and more services in the digital world are available. Besides e.g. shopping, gaming and general information, different social networks now offer preventive and therapeutic health-oriented services. When being asked by several young people, with whom I have been working in a clinical setting, to offer conversations over the Internet that enables both to see and to hear each other in real time, I decided to conduct a pilot study which is presented in this paper. The aim was to investigate the feasibility of offering supportive therapy using video calls over the Internet.

Akut sjukdom innebär ofta ett hot mot tillvaron. Utöver det rent fysiska utgör störd dygnsrytm stora problem för intensivvårdspatienter. De vårdas i en högteknologisk miljö som stör sömn och vila. Detta har sammantaget negativ inverkan på både den mentala och fysiska återhämtningen. För att kompensera störd nattsömn har många intensivvårdsavdelningar infört strukturerade vilostunder under vilka patienterna inte ska få störas.