Biologiska läkemedel är stora molekyler som har renats eller producerats från ett biologiskt ursprung. De används idag i stor utsträckning runt om i världen på grund av deras effektivitet att minska symtomen som kan uppstå vid olika mycket svåra sjukdomar. Detta arbete fokuserar på biologiska läkemedel som hämmar cytokinet tumörnekrotisk faktor (TNF). Läkemedlen används bland annat vid svåra autoimmuna sjukdomar. Vid autoimmuna sjukdomar aktiveras cellerna i immunsystemet vilket leder till utsöndring av olika cytokiner till exempel interleukin 1 och TNF.

Biologiska läkemedel är stora molekyler som har renats eller producerats från ett biologiskt ursprung. De används idag i stor utsträckning runt om i världen på grund av deras effektivitet att minska symtomen som kan uppstå vid olika mycket svåra sjukdomar. Detta arbete fokuserar på biologiska läkemedel som hämmar cytokinet tumörnekrotisk faktor (TNF). Läkemedlen används bland annat vid svåra autoimmuna sjukdomar. Vid autoimmuna sjukdomar aktiveras cellerna i immunsystemet vilket leder till utsöndring av olika cytokiner till exempel interleukin 1 och TNF.

In this thesis the methane gas potential of three different substrates, two algaes Saccharina latissima and Laminaria digitata and biosludge mixed with paper fiber was studied. This was done by batch experiments in a laboratory environment to examine the gas production and composition of the produced gas.Biogas production is a complex anaerobic digestion process in which various microorganisms decompose the substrate in steps and at the end produce biogas and a residue. Many factors affect the production of gas, for example the substrate content, temperature and pH in the digester.The analysis of methane potential were divided into two experiments. In experiment 1 substrates were digested along with inoculum from Växjö waste water treatment plant in a temperature of about 37 ?C.

Osteoartrit (OA) är en vanligt förekommande sjukdom och bidragande faktor till nedsatt förmåga att träna och tävla hos hästar. Ledinflammation som det också kallas drabbar alla häst raser och i alla grenar inom rid, trav och galoppsporten. Inflammationen kan drabba alla de ingående strukturerna i leden och ger kliniskt upphov till hälta, smärta, ökad ledfyllnad och stelhet. Sjukdomen bidrar till sämre djurvälfärd och ekonomiska förluster inom hästindustrin. Orsakerna kan vara många.

During the year of 2008, a powerful earthquake hit the southern part of Iceland, which changed the geothermal conditions in the area around the city of Hveragerdi. Elevated soil temperatures in a nearby forest plantation have contributed to a unique opportunity for researchers to study how an increased soil temperature affects the boreal forest ecosystem, something that partly can be connected to the climate changes which are happening today. The boreal forest is representing a carbon sink and a buffert for the emissions that occurs. Changes in this ecosystem will for that reason contribute to major impact for the global carbon cycle. To study the impact of how elevated soil temperatures affects different processes in a plantation of Sitka spruce, studies were made on the photosynthesis of the trees and the respiration from the soil.

The main aim in this Master thesis is to analyse how an ideological view may have influenced the shape of hierarchies with a specific concentration on the concept of fiction genre in the latest versions of the systems SAB and DDC. Our thesis is that no theoretical classification scheme can be recognized as objective. With an ideological/institutional perspective we look at the structures behind these systems. As a vehicle we use the hermeneutic circle to show the play between part and unit by focusing and analysing three different levels: the content level the concept level the ideological level. The first level is in the shape of a historical background and an analysis of concept with focus on content.

High levels of Hg in fish in Swedish lakes have been a problem along time in Sweden. The major concern is production and accumulation of the most toxic form of mercury; methyl mercury (MeHg). Consequently, in about half of our 83 000 lakes fish contain concentrations above the recommended limit for human consumption of 0,5 mg mercury per kg fresh weight (most of it in the form of MeHg). Consumption of fish containing too high levels of MeHg may cause problems for both humans and animals. Three major sources of MeHg in surface waters are: 1) runoff from terrestrial areas, 2) deposition from the atmosphere, and 3) internal production of MeHg in lakes and streams. The aim of this study was to investigate the effect of clear-cutting on the concentration of Hg and MeHg into draining streams.

To have a forest area close to the city is of great importance for the city population?s well being. Children develop their motor skills, concentration and imagina-tion and the adults have a place to shake of the stress from work. Forest areas are used to exercise at, play in and to find a moment of peace and silence. The urban forest and the old farming pastures at Markussonvallen and Per-Isakssonvallen already has natural assets worth to preserve and a great potential to create more. The goal is to develop a forest with a variation of tree species and ground vegetation that will appeal to the human senses and different animal species such as birds, insects etc.

The Swedish Animal Welfare Act say that all milking cows must have access to pasture in summer time. That was a gift to Astrid Lindgren o her 80th birthday from the Swedish Government. Sweden is a predecessor in animal welfare, but how well do we live up to these big expectations? In this thesis I will examine how well the pasture for milking cows works. I have been interviewing farmers with milking cows and people in the business. I have also been searching information on Internet, and using the library of Alnarp. Cows that are kept on pasture are exposed to different kind of parasites, but on the other hand they run a smaller risk to getting acetonemi, pareses and udder infection. Veterinary Pierre Nordmark means that cows on pasture are more healthy then cows kept inside all summer.

Native spider silk is an attractive lightweight natural polymeric material with a unique combination of strength, extendibility and flexibility. Synthetic, recombinant spider silk is an attractive biomaterial with several possible fields of application. When a foreign material is introduced to blood, this can for example cause unwanted coagulation and complement activation. The aim of this study was to investigate if coatings of heparin or albumin could improve the blood compatibility of films of recombinant spider silk and to develop an initial method to do so. Hypothetically, objects like pacemakers, stents and dental implants could be covered with spider silk films of high blood compatibility to reduce potentially harmful foreign body reactions caused by the immune defense. Increased blood compatibility would likely lead to improvements for both the individual patients and the society thanks to reduced load on healthcare institutions. Our objective was to assess the blood compatibility of both functionalized and non-functionalized recombinant spider silk by evaluating coagulation and activation of the complement system of the immune defense. Coagulation was evaluated visually on glass slides and complement activation was analyzed by measuring the concentration of the complement system mediator C3a in blood samples that had been exposed to the different materials. This study introduces a non-toxic and easy performed method of improving the blood compatibility of recombinant spider silk films by adding a heparin coating. Heparin coated surfaces had statistically significantly higher blood compatibility than uncoated surfaces. The effects of albumin coating of films were less clear compared to the results of heparin coated films. Complement activation could not be evaluated because of high activation in all samples prior contact with the materials that were included in the study..

This thesis is a part of the project "Sustainable harvesting and storage of sugar beets, more sugar to practice". The work has included a large part of practical experimental work with weight measurement, graduation and storage planning. The aim of the project is to be able to see whether the cultivars react differently in different storage conditions. The project has included storage under controlled conditions to give as accurate results as possible. To be able to mimic the farmers own preconditions the samples was harvested with a conventional Holmer.This project has two parts, one concerning the nature, time and temperature on storage where a number of different cultivars where investigated during three different recording times, two different temperatures and controlled in a controlled environment.

Sewage sludge contains plant nutrients and has earlier been utilised as fertilizer to cropland. Unfortunately not only plant nutrients but also heavy metals, pathogens and organic contaminants tend to accumulate in sludge. The suitability to use sewage sludge in agriculture has therefore been subject to several discussions over the years. The Swedish food industry does no longer accept sludge as fertiliser for Swedish producers. In 1999 the Swedish parliament accepted several objectives for environmental protection. In order to prevent environmental pollution and further exploitation of the earth crust, one of these objectives confirm that phosphorous from sewage shall be recirculated to arable land.

Idag har ma?nniskor friheten att va?lja var, na?r och pa? vilket sa?tt de vill anva?nda sina smartphones och dess funktioner, oavsett a?ndama?l. Hur ga?r den anva?ndarmo?jligheten ihop med inla?rning? Hur mycket av koncentrationen kan beha?llas under en inla?rningsprocess med en smartphone na?rvarande och anva?ndandes? Pa?verkar na?rvaron och anva?ndningen av smartphones anva?ndarnas fo?rma?ga att skilja och bearbeta information fra?n olika ka?llor? Den ha?r studien syftar till att underso?ka deltagarnas fo?rma?ga och uppfattning att kunna sa?rskilja och bearbeta information ifra?n olika ka?llor genom diagnosiska prov, baserade pa? fo?rela?sningarnas inneha?ll som deltagarna fick ta del av under tva? fo?rela?sningstillfa?llen. Deltagarna delades in i tva? grupper da?r den ena gruppen fick beha?lla sina smartphones under fo?rsta fo?rela?sningen medan den andra gruppen ombads la?gga undan sina smartphones.

The world around us is shrinking and globalization and capitalism are processes affecting the world. Global trends, like outsourcing and relocation of firms to low-cost countries, have become more common. This creates a huge vulnerability in the municipalities that today are concentrated around a single large company. One of these is Olofström which today is one of the most vulnerable municipalities in Sweden and whose survival today lies in the hand of the company ?Volvo Cars Corporation?.

I dag lider ca 25-35 % av skolungdomar av psykisk ohälsa. Tidigare forskning har visat att denna ohälsa beror på att ungdomar sover alltför lite, vilket i sin tur associerats till en ökad användning av sociala media. Orsakssambanden är emellertid oklara och varierar mellan studier. Av den anledningen genomfördes en enkätstudie på gymnasielever, för att ytterligare belysa hur sambanden ser hos svenska ungdomar.I undersökningen användes två frågeformulär bestående av en reducerad version av KASAM, ett sömnformulär, samt frågor angående sociala media.I studien deltog 51 elever (M: 18.0 år, SD 0.35), varav 22 kvinnliga och 28 manliga elever i ÅK 3. Resultatet visade att cirka hälften av eleverna (49 %) ansåg sig sova signifikant kortare tid än vad de önskade (p<0.0001).