Diabetes mellitus is an endocrine disorder affecting a range of different mammals, including dogs, cats, horses and humans. Worldwide, 347 million people have diabetes, and the disease is an increasing burden on the world?s poorest countries. The disease is characterised by chronic hyperglycaemia and afflicted individuals experience increased thirst, polyuria and weight loss, sometimes despite increased appetite. Diabetes mellitus is either insulin dependent or non-insulin dependent.

Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

Bakgrund: Ett sätt att minska risker vid handel med finansiella instrument är att bygga portföljer. För att kunna hantera portföljer med olika finansiella instrument och valutor samt kunna hantera flera portföljer samtidigt, används portföljhanteringssystem. Studenter kan genom att använda sig av sådana system lära sig hur finansiella marknader fungerar. Kraven på ett portföljhanteringssystem är inte desamma som kraven på ett kommersiellt system och därför finns det ett behov att utveckla en modell för denna kontext.Syfte: Denna uppsats ämnar bygga en modell i PowerPlus Pro som studenter kan använda sig av för att befästa sina kunskaper och öka sin förståelse för hur finansiella instrument fungerar.Metod: För att bygga modellen har kvalitativ metod används och för att studera hur portföljhanteringssystem ska byggas och anpassas efter studenters behov har kvalitativa intervjuer använts.Slutsatser: Vår modell uppfyller de krav som ställts på den och är anpassad för undervisning på ett universitet genom att den är användarvänlig och pedagogiskt uppbyggd. Modellen lämpar sig inte för användning av markadsaktörer.     .

This thesis describes a tool for data mining used to optimize ambulance preparedness. The goal with the tool was that it should be able to retract the information necessary to be able to analyze and calibrate the preparedness model used in the software ResQMap. ResQMap is used by SOS Alarm, who are responsible for the Swedish emergency number 112, as a decision support tool for ambulance operators. It is developed by Carmenta AB, who are the supervisors of the thesis work. Also, a minor study of the preparedness models variables has been performed in order to be able to evaluate the function of the tool.

Kundrelationer är ett hett diskuterat ämne i dagens kraftigt konkurrens-utsatta företagsklimat. Starka kundrelationer är viktigt för att stärka företagets lönsamhet. För att skapa starka relationer krävs att företagets resurser används rätt. Kundportföljanalys (KPA) är en modell som används för att segmentera ett företags kunder i olika kundgrupper för att på så vis skapa underlag som tillåter företaget att utveckla strategier för varje kundgrupp. Det tillåter företaget att fördela sina begränsade resurser på ett så effektivt sätt som möjligt i syfte att stärka företagets kundrelationer.

Comfort analyses regarding human induced vibrationsIt is not too common among civil engineers in Sweden to perform comfort analyses considering the vibrations caused by human activities. In addition, the Swedish standards lack requirements to be used for comfort analyses in design of floor-systems. The demand for large spans in combination with slender slabs, is today a reason to investigate the floor-system constructions, in order to prevent disturbing vibrations and oscillations.The purpose of this thesis is to create a guide for how a comfort analysis, considering vibrations, should be implemented. Göran Svedenbjörk who is an expert in structural dynamics has been interviewed where he presents his latest project Värtaterminalen and answers some questions about vibrations due to human activities.Floor-systems, consisting of concrete slabs supported by steel or concrete beams, have been investigated with simulations in the finite element program Abaqus. In the simulations, the influence of various factors on the natural frequency of floor-systems and the acceleration level caused by dynamic loads, is studied.

Bakgrunden till studien är att forskningen visar att elever i svårigheter utvecklas mest kunskapsmässigt och mår bäst socialt av att inkluderas i klassens undervisning. Trots detta finns det väldigt ofta en önskan att exkludera dessa elever eftersom många lärare inte anser sig klara elever med specialpedagogiska behov inom den ordinarie undervisningens ram. Detta har lett till en rättvise- och inkluderingsdebatt såväl som en debatt med ekonomiska förtecken. Frågor som lyfts är ?Var mår eleverna bäst och finns det metoder som fungerar så att alla elever kan inkluderas?? Min studie syftar till att undersöka möjligheten till ett inkluderande arbetssätt i engelskundervisningen med hjälp av Europeisk Språk Portfolio och Autonomous Learning.

Multi-brand portfolios are characterized by comprising many brands in the same product category. Companies that have chosen to organize their products according to this strategy are facing both possibilities, such as expanding the accessible market size, and challenges such as how to organize the brands, their individual roles and their relation and position to the other brands in the category to maximize revenues. To address these aspects of multi-brand portfolios, I have investigated four product categories where multiple brands are represented at Mölnlycke Health Care, Unilever, Fagerhult and L?Oréal; how the multi-brand portfolios are organized, how the segmentation, positioning and product differentiation are done and what advantages and disadvantages that are associated with this strategy. My conclusions are that multi-brand portfolios can be organized in many different ways and to become successful, they have to be set in relation to the company?s whole brand architecture.

The Swedish Cellulosa Companiy, SCA, has today 280 000 ha planted with lodgepole pine (Pinus contorta var. latifolia) (?C?) which is equivalent to 14 % of its total forest area. Exotic lodgepole pine has in previous experimental stands shown a superior growth than the native Scots pine (Pinus sylvestris L.) (?S?).But also the comparison could be questioned because stand histories were was unknown and also differences in age between C and S existed.

Syftet med denna studie var att undersöka vilka utvecklingsmaterial som används på förskolorna i en mindre kommun i Sverige och om användandet av dem kan leda till att enskilda barn bedöms. Ett annat syfte var att ta del av förskollärares tankar kring begreppet bedömning då vi själva ville ha en ökad förståelse för detta begrepp. Vi valde att anta en hermeneutisk ansats och arbetade på ett kvalitativt arbetssätt. För att samla in resultat till vår studie genomfördes intervjuer. Intervjuerna skedde med utbildade förskollärare.

Bakgrunden till studien är att forskningen visar att elever i svårigheter utvecklas mest kunskapsmässigt och mår bäst socialt av att inkluderas i klassens undervisning. Trots detta finns det väldigt ofta en önskan att exkludera dessa elever eftersom många lärare inte anser sig klara elever med specialpedagogiska behov inom den ordinarie undervisningens ram. Detta har lett till en rättvise- och inkluderingsdebatt såväl som en debatt med ekonomiska förtecken. Frågor som lyfts är ?Var mår eleverna bäst och finns det metoder som fungerar så att alla elever kan inkluderas?? Min studie syftar till att undersöka möjligheten till ett inkluderande arbetssätt i engelskundervisningen med hjälp av Europeisk Språk Portfolio och Autonomous Learning.

Like many small-time companies there is a need to improve the flow of materials at HSP-Gripen AB. The company develops and manufactures hydraulic-powered grapples for the machine- and forest industry. By mapping the material flow in the current production and gathering necessary data, suggestions on how different parts of the production could be controlled is presented in this dissertation. This has been achieved by the study of relevant scientific literature. The suggested ways of controlling the production consist of 2-bin systems, hybrid material flow system as well as a cyclic product-planning.

Historically transformers with system earth equipment have been modeled as open circuits in zero sequence. This approximation has been satisfying, but lately it has been discovered that equipment on one side of the transformer have responded to faults that occurred at the other side. Most of these problems took place when the majority of the system on the secondary side of the transformer contained cables. These findings have led to questioning whether or not the former model of the transformer in zero sequence is correct. This report investigates if it is necessary to represent the transformer in zero sequence in another way than it is usually done today.

In an ever more competitive environment Sandvik Materials Technology,SMT, runs a large-scale program to improve their processes for product development.The purpose with the program is to increase the company?s profitability by increasingthe number of new products in their product portfolio. The strategies SMT is usingfor reaching their goals are to change the way they work with product development byreducing lead time and learning how to prioritize products with the highestprofitability. In the R & D Department the work of improvement pursue by adaptingLean R & D to their way of working. Lean R & D encourages working withcontinuous improvements and eliminating waste.The main purpose for this Master?s Thesis is to develop didactic support to make iteasier to implement Lean in SMT R & D department.

Today we can create digital 3D models which can be realised almost instantly through production methods such as 3D printing and computer controlled milling.What if this same technology could be applied to the development and construction of terrain parks?With snow as the material tools could be developed using similar principles to design and sculpt the surface, only on a larger scale.How would terrain park designers adapt their process to use this new technology? In this Industrial design thesis I explore how the ideas of the terrain park designer can be expressed through such a system with focus on the designers knowledge and skill without the need to learn complicated 3D programs.Sketch, create, ride. .