The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

By tradition, archival sciences has emerged in a context with defined information processes, with explicit information producers and custodians to which consumers make requests for the information. In this process, the archival science has developed methods and strategies to preserve authentic and reliable records and by that providing trustworthy information. In an online society, people are using the internet to get information for different purposes. Even though there is no legal obligation to guarantee the authenticity, it is of societal importance that the end users get trustworthy information. In this online context, open data is a trend that is growing fast over the world and it is interesting because its conditions raises many questions regarding authenticity.Since open data is free to reuse, link and combine with other information, and it is preferably in primary format it raises questions about how to maintain the integrity and identity of the information, which is the constituents of authenticity as it is used in this work.

To differentiate between bones from sheep (Ovis aries) and bones from of goats (Capra hircus) is a long lasting challenge for zoologists, archaeozoologists and osteologists. Especially considering archaeological remains which are often found fractured and poorly preserved due to taphonomic processes. Zeder & Pilaar?s (2010) and Zeder & Lapham?s (2010) methods of species differentiation has shown promising results when used on bones from modern sheeps and goats. This paper aims to evaluate these methods by exerting them on excavated bones from kv.

The concentration and storage of organic chlorine and chloride were determined in soil, to a depth of 40 cm, in a coniferous forest in the Stubbetorp catchment area in south-east Sweden. Also, the spatial distribution of the two forms of chlorine was determined. Soil samples were collected at 49 of the nodes in a grid with approximately 105 m between the nodes. The analysis of spatial variability suggested that no spatial autocorrelation was present either within the variable organic chlorine or chloride. This means that no sample was more influenced by another nearby sample, as compared to other samples further away.

An important task for project managers in multi-project environments is to effectively choose the right people to the project team. For organizations, it means being able to prioritize and plan human resources among the various projects running in parallel. The purpose of this paper is to describe how a project manager in multi-project environments looks at the allocation of people in their projects. We did our research through literature reviews and interviews with seven project managers.The research shows that the studied organizations highlight both the expertise and the personal factors in an election. They do not use any specific personality test to identify their staff.

The aim for this master thesis is to create an understanding of the intersubjective processes of how individuals are experimenting with their identities in social media and the consequences for the identity and embodiment. The thesis is completed with the help of discourse analysis and a starting point in four complementary theories. Central to the implementation of the analysis is the concept of diffraction. Therefore the thesis is, which is reflected in the choice of theoretical approaches and methods, critical to many aspects of classical philosophy of science and method. The empirical material is based on interviews.

Noise in schools can have negative effect on the teaching environment and speech perception. The national Child Environmental Health Surveys (BMHE) conducted in 2003 and 2011 studied how 12-year olds experience their sound environment in school. Results showed that the number of pupils that experience annoyance from noise increased from 2003 to 2011.Aim: The aim of this study was to study how 12-year olds perceive their sound environment in school.Methodology and material: A quantitative questionnaire survey was conducted in the sixth grade at two schools. The questionnaire used included questions from BMHE and self-produced questions. Sixtynine students answered the questionnaire.Results: Over 50 % of the respondents experience annoyance from noise in school several times a week.

Medieföretaget AB is a Swedish Media Company that covers several different business areas.The company daily produces one of the biggest newspapers in Sweden and publishes editorialnews on one of the country?s most visited news homepage. The company also has smallerfirms that produce new business models. Due to big changes in the media climate over theworld and a new company management team the company in November 2008 started adepartment for innovation. The main purpose of the department was to create a structuredway for managing ideas and to promote innovation.

This essay discusses the students? thoughts about the teacher's response to their gender identity. The students discuss their right to have an intergender identity which means that they don?t identify themselves in the traditional sexes, man and woman, and the gender role each category has. They want to be called with a neutral pronoun and not be seen like boys or girls.

Title: Bottleneck management through materials administration Course:  4FE05EAuthors:  Mikael Karlsson and Johannes Mueller  Examiner: Helena ForslundKey words:  Bottleneck management, material management, process description, timber, proceduresPurpose:   The objective of this study is divided into three parts, all three parts of the purpose aim for the same goal. Namely, to improve the material management so that this enables the bottleneck in the planing mill to keep a continuous  flow, and thereby minimizing the risk for production stops at LB-Hus.  Part.  1:  Identify  and  analyze the material management  connected to  the planing mill  in order to identify problem areas.Part.2:  Identify  improvement potential  in the material management connected to the planing mill.  Part.3: Suggest improvements in the material management connected to the planing mill. Theoretical framework: Process mapping, inventory accounting, balance safety, inventory availability / service levels, safety stock and reorder point, forecasting and routine descriptions.Empirical foundation:  Interviews carried out at LB-House,  illustrated with the help of process maps and a description of each process.  Conclusions:  To work with  the  suggestions  given  and  to  follow  clear procedures  in  all  processes would  result in  a more  efficient  inventory management,  it would also present  a  solution  to  the problem regarding the planing mill being a bottle neck.Suggestions for further research: Review and map the information flow from demand to production start.

Information technology and globalization has led to an increasing competition and service production has been more and more independent of locations. This has made a market of outsourced telephone costumer service possible. Due to high establishment the market has been saturated and with that price has sunk. Customer companies have the last few years got more negative to outsourcing of their telephone customer service as they through operating the customer service internally want to get closer to their customers.In the empirical study the writers try to figure out which companies the callcenters should try to aim towards to get long and profitable cooperation. This will be done through deducing guiding principles from theories about how different factors around companies costumer service should look like.

Due to human influences on the climate an increase in Earth's mean temperature is today an accepted conception. With a rising temperature discussions have started how the climate in an area will change in the future. Equally interesting and important is it also to study the precipitation in an area. Precipitation is the factor, next to temperature, that affects most how a climate in an area looks like and feels. Since precipitation is connected to evaporation the latter parameter is also of interest to study.

Begreppet landskap kan betyda både utsiktslandskap, så som det används på engelska , och område, region, som är grundbetydelsen i de germanska språken. Torsten Hägerstrand introducerade i början på 1990-talet begreppet förloppslandskap, som vänder sig mot ett statiskt betraktande av landskap och istället tar fasta på landskapets processer. Målet med denna litteraturstudie är att presentera en översikt av förloppslandskapets idéer. Syftet är att med detta som bakgrund föra en diskussion kring förloppslandskapets relevans i dagens planeringssituation. Europeiska landskapskonventionen företräder en landskapssyn där samspelet mellan natur och samhälle betonas, men till skillnad från förloppslandskapet så är fokus inställt på människans upplevelse.

This thesis explores strategic communication management within the non-profit sector. Communication models need to be adapted to the specific sector as different sectors require different approaches of strategic communication management. In the spring of 2013, the non-profit organization Save the Children Sweden initiated a communication model based on volunteer communicators. The following study explores how non-profit organizations can manage communications with a focus on volunteers as a communication resource. The applied research questions concern how volunteers may be integrated into communication activities, the opportunities and challenges connected to involving volunteer communicators and how this may affect the role of the organization's employed communicators.

SammanfattningDen här studien är en litteraturöversikt som analyserar forskningsbaserade texter och lyfter fram syften med drama/teater i gymnasieskolan, utifrån den analyserade litteraturen. Studien redogör både för syften med drama/teater som enskilt ämne och integrerat med andra ämnen.Studien visar att drama/teater är användbart både som ett medel där målet är att lära sig andra ämnen, och där målet är kunskaper i drama/teater. Den ger exempel på att eleverna, med hjälp av drama/teater, kan få stöd i att uppnå flera av målen i gymnasieskolans senaste läroplan från 2011. Exempel på hur drama/teater kan vara till nytta i andra ämnen är att det kan användas för att förbättra elevers läsning och textförståelse oavsett ämne. Drama/teater har också ett egenvärde som bland annat består i att eleverna lär sig att använda sina erfarenheter för att förstå omvärlden, att de lär sig att uttrycka sig på sitt individuella sätt och att de tränar på att våga ta ställning.