Rheumatoid arthritis is an autoimmune disease, where joints are attacked by the own immune system, leading to chronic inflammation and destruction of bone and cartilage. Inflammation is a complex process, controlled by many different substances. One of them is adenosine, which has anti-inflammatory properties. In this project, three polymorphisms in different genes, involved in synthesis and signaling of adenosine, were genotyped for 188 patients with RA and 362 controls without RA. The results shows that for the polymorphism in A2a, a gene coding for an adenosine receptor, there was no significant difference in genotype distribution between the groups.

Background: Sleep-disturbances in persons with Alzheimer´s disease are prevalent. They are characterized as increased frequency and duration of awakenings, decreased slow-wave sleep, REM-sleep and increase of day-time napping. Depression and lower quality of life are associated with sleep-disturbances. Altogether a significant source of stress for caregivers and an important factor in institutionalization. Non-pharmacological treatment alternatives are rare.Method: Single-case A-B-C design, with non-concurrent multiple baselines, a pilotstudy.Aim: To explore if an educational program on sleep, sleep disturbances and behavioural change directed towards caregivers improved sleep, depression and quality of life in persons with Alzheimer´s disease living at home.

Bakgrund: Depression ses som en del av ett bipolärt syndrom med depressiva och maniska eller hypomana sjukdomsepisoder eller som ett unipolärt syndrom endast med depressionsepisoder. Fysisk aktivitet definieras som kroppens rörelse skapad av skelettmuskulaturens sammandragning. Den leder till att kroppen gör sig av med energi och har kopplats till att minska depressionsrisken, öka välbefinnandet och bryta isoleringen. Att motivera äldre med depressionssjukdom till fysisk aktivitet är inte helt okomplicerat. Sjuksköterskan har en viktig roll i att integrera fysisk aktivitet i omvårdnaden för denna patientgrupp.

SummaryPatients with burn injuries involving more than 20 percent of the total body surface area lose a lot of fluid and are in the risk of developing a severe hypovolemia. Fluid resuscitation is a corner stone in burn care and is important for preventingfurthercomplications. The most common resuscitation formula is the Parkland Formula. Hourly urine output is a measure used to evaluate if the fluid given is sufficient enough to maintain a sustainable tissue perfusion. Inhalation injury, abuse of alcohol and drugs are some of the factors that may increase the amountoffluid needed.

?Crumbs make crust? is a collection of memories, told in words and pictures. It is a praise of the ordinary person and the essentials of everyday life.I have several years of experience from working with elderly people in social home care service. There I was given the opportunity to meet different personalities and take part in their stories and everyday life. I have followed this life and collected memories and in this project I have portrayed an older generation, now looked upon only as crumbs, yet crumbs that in many ways rested on and still rests on society today..

Introduction: Anxiety and depression are common among patients enrolled in psychiatric outpatient care. Ear Acupuncture is an alternative form of treatment that has been shown to relieve anxiety and depression in previous studies.Aim: To evaluate ear acupuncture as a group treatment for depression and anxietyMethod: A psychiatric outpatient clinic has been offering group treatments with ear acupuncture for anxiety and depression for 5 weeks. Participants of the study have answered self-rating scales Montgomery Åsberg Depression Rating Scale, Beck Anxiety Inventory and Sheehan Disability scale before and after the treatment period. Material was collected in the period 2008-2012 and has been analyzed in SPSS.Results: Data from 31 patients were included in the study. The results from the study showed a significant difference, between the measurements before and after treatment, with a reduction of the average values in the three different scales.Summary: From this study, it is difficult to draw any conclusions about the effect of ear acupuncture.

Success in treatment with platinum-based chemotherapy against different types of cancer tumors is limited by side-effects such as hearing loss which can have a large impact on the individual`s quality of life. It is of great importance to continue with studies that address this complex of problems.Objective: The aim of this literature review is to investigate the impact of platinum-based chemotherapy on hearing in children and adolescents treated for different types of cancer.Method: A descriptive review of literature was made based on sources from 15 different studies on the impact of platinum-based chemotherapy on hearing in the target group.Results: The survey of the studies shows that platinum-based chemotherapy causes incidence of hearing loss by differing degree in the target group. Dosage of a platinum-based substance appeared to be the most significant factor. Treatment with both cisplatin and carboplatin was more ototoxic than treatment with only one of these. Greater risk for hearing loss was to a higher degree observed in younger children.

This thesis discusses the differences between how archaeologists and cultural geographerdescribe the early Iron Age on Gotland. What objects, phenomenon and arguments do theyuse to describe this period. Four publications have been analysed in this study, two written byarchaeologists, two by geographers.The differences in how they describe the period in question are significant. Both disciplinesgive a very fragmentary description of the older Iron Age in Gotland..

På många intensivvårdsavdelningar skrivs det dagbok för patienten. Dagboksskrivande på intensivvårdsavdelning är dokumentation av vårdtiden skrivet till patienten av sjuksköterskor och annan vårdpersonal och i vissa fall närstående. Intensivvårdsavdelningen är en tekniktät miljö som kan upplevas skrämmande och stressig för patienten, vård på intensivvårdsavdelning kan orsaka posttraumatisk stress syndrom efter vårdtiden. Forskning visar att dagboken tillsammans med uppföljningsverksamhet efter vårdtiden på intensivvårdsavdelningen kan minska risken för utveckling av post traumatisk stress syndrom. Syftet med studien var att beskriva innehållet i patientens dagbok från vårdtiden på intensivvårdsavdelningen.

Syftet med denna systematiska litteraturstudie var att beskriva patienters upplevelse av livskvalitet samt sjuksköterskans omvårdnadsåtgärder i samband med cytostatikabehandling vid cancersjukdom. För att besvara studiens syfte har sökning efter artiklar (n=17) genomförts i databaserna Blackwell Synergy samt Elin@Dalarna. Följande sökord har använts i olika kombinationer; cancer, patients, experience, nurse care, quality of life, scale, instrument, chemotherapy och care. Resultatet visade att cytostatikabehandlingen hade både positiv och negativ inverkan på patienternas livskvalitet. Livskvaliteten ökade då symtom lindrades.

This study aims to investigate possible correlations between cognitive functions and self perceived psychological wellbeing, possible correlations between cognitive functions and degree of mindfulness and possible correlations between degree of mindfulness and self perceived psychological wellbeing. 18 patients diagnosed with ICD-10 taking part in a transdiagnostical cognitive behavioural group therapy participated in the study. The study measures relevant variables before and after a group therapy. Of the 18 patients participating, only 11 were able to be tested on both occasions due to time limit. The following tests are used: Rey Auditory Verbal Learning Test, Wechsler Adult Inventory Scale-III, Trail Making Test, Controlled Oral Word Association Test, Colour Word Test, Beck's Anxiety Inventory, Beck's Depression Inventory, Quality of Life Inventory and Kentucky Inventory of Mindfulness Skills.

The aim of the present literature study was to describe the significant factors contributing to the development of moral distress and the consequences of moral distress can lead to in the nurse profession. A literature search was performed in the databases Medline through PubMed and Academic Search Elite on the basis of in advanced defined criterions. A total of 19 articles was reviewed and included in the study. The main result revealed that nurses experience moral distress and that it is frequent within the nurse profession. The findings revealed that there seem to be several significant factors in the development of moral distress, such as providing life-sustaining care, competing loyalties, conflicts with the physician, communication barriers, emotional barriers, cultural barriers, regulation and rules and working environment that gives the nurse difficult or unsolved ethical dilemmas.

Bakgrund: P? akutmottagningen v?rdas patienter som ?r i akut behov av v?rd. En del av patienterna beh?ver l?ggas in p? en v?rdavdelning efter att de blivit bed?mda av l?karen p? akutmottagningen. F?r att s?kerst?lla patients?kerheten och f?r den fortsatta v?rden ?r det n?dv?ndigt att sjuksk?terskan p? akutmottagningen ?verrapporterar n?dv?ndig information till sjuksk?terskan p? v?rdavdelning.

Breast cancer is the most common form of cancer affecting women. The treatment of breast cancer may lead to forcing the woman to remove her breast. The breast is a symbol of femininity and sexuality for many women. The purpose of this literature-based study is to describe women's experiences of altered body image and sexuality after mastectomy. This may provide a better understanding of the nurse in responding to these breast cancer patients.

ObjectiveThe aim of this study was to explore nurses' experiences of informing relatives to critically ill patients in the intensive care unit (ICU).MethodThe study was descriptive with a qualitative approach. Nine nurses were interviewed. The study took place in a university hospital in the midst of Sweden. An interview guide was used, designed in consensus with the study questions. Data was analyzed via qualitative content analysis.FindingsMeeting and preparing relatives at the arrival at the ICU seemed valuable and led to safety and participation among relatives.