Hörselnedsättning hos barn och ungdomar till följd av platinabaserad kemoterapi - en beskrivande litteraturstudie
Success in treatment with platinum-based chemotherapy against different types of cancer tumors is limited by side-effects such as hearing loss which can have a large impact on the individual`s quality of life. It is of great importance to continue with studies that address this complex of problems.Objective: The aim of this literature review is to investigate the impact of platinum-based chemotherapy on hearing in children and adolescents treated for different types of cancer.Method: A descriptive review of literature was made based on sources from 15 different studies on the impact of platinum-based chemotherapy on hearing in the target group.Results: The survey of the studies shows that platinum-based chemotherapy causes incidence of hearing loss by differing degree in the target group. Dosage of a platinum-based substance appeared to be the most significant factor. Treatment with both cisplatin and carboplatin was more ototoxic than treatment with only one of these. Greater risk for hearing loss was to a higher degree observed in younger children. Sex as a factor had almost no significance except in one study which showed that male patients suffered greater hearing loss than female patients.Conclusion: Despite that degree and impact of hearing loss in children and adolescents following platinum-based chemotherapy differs substantially in different studies it obviously appears that treatment can affect hearing in the target group.