The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

Metso Paper i Sundsvall AB utvecklar och tillverkar utrustning för pappersindustrin. En av huvudprodukterna är TwinRoll pressar. TwinRoll pressarna är konstruerade mot kundorder och enstyckstillverkade. Innan de levereras till kund ska de verifieras genom en slutkontroll. Idag utförs denna verifiering med hjälp av komplett montering.

In this thesis, three separate experiments have been performed on different aspects of the interaction between the causal agent of clubroot, Plasmodiophora brassicae, and its hosts. In the first experiment the pathotype of the P. brassicae single spore isolate, which is currently used to construct a reference genome, has been classified using the ECD bioassay. The disease severity of infected plants was scored according to two different scales and the pathotype was determined according to three previously published guidelines. The results were compared to previous published studies describing the e3 isolate. The life cycle of P. brassicae is not well understood.

This thesis was conducted at Linköping University and Saab Aerostructures DPS, Linköping, and focuses on the possibilities of flexible fixturing in machining applications. The thesis is part of the research project "Koofix", which is collaboration between Linköping University and a number of companies.The thesis is aimed towards small batch production which, for Saab Aerostructures DPS, means diverse part geometry and that parts are manufactured in very small numbers, sometimes just one piece. The result of this is that expensive dedicated fixtures are made for most parts. By introducing more flexible fixturing methods to this kind of production the cost of fixtures and tooling will be reduced, and make the production more efficient.New flexible fixturing methods has been presented and evaluated through the thesis, which has resulted in three different concepts. These concepts have been the result of literature screening and study of current manufacturing process at Saab Aerostructures DPS.

The purpose of this study was to develop a reliable molecular-genetic method to determine the different species of helicobacter in dogs. The study is part of a larger project to map the prevalence of Helicobacter spp in healthy and sick dogs in Sweden, and to determine the possible connection of Helicobacter spp infection with gastrointestinal diseases in dogs. Several published studies have reported on the prevalence of Helicobacter spp in dogs. The problem is that three of the most common species are so alike that a 16SrRNA-PCR with sequencing is not able to differentiate between them. In this study, DNA has been purified from samples and then a Multiplex PCR has been performed. Multiplex PCRs use multiple primers in one single PCR.

Svenska Aerogel AB has developed the material Quartzene® which is of the typeprecipitated silica and contains calcium - magnesium silicate ((Ca, Mg) SiO3). Thematerial is used for molecular filtration of contaminated air. Qartzene?, which is inpellet form, is porous and has a high internal surface which is a requirement for themolecular filtration. With the use of various impregnations, filtration can affect thedesired outcome.

The escalating usage of pyrethroids has resulted in an increased awareness about resistance towards pyrethroids in insects. Pyrethroids inhibit voltage-sensitive sodium channels (VSSC) in nerve cell membranes and are composed of synthetic molecules based on pyrethrins present in pyrethrum extracts from Chrysanthemum species. VSSC are transmembrane proteins that are important for electric signalling over the membrane in insects. Mutations in the gene encoding the sodium channel have proved to be a common reason for resistance against pyrethroids. Pyrethroid resistance among pollen beetles is spread all over Sweden and also abroad and is increasing.

The aim of the project was to investigate if Swedish rodents, brown rat (Rattus norvegicus), house mouse (Mus musculus), wood mouse (Apodemus spp) and water vole (Arvicola terrestris) captured in pig herds and in urban areas, constitute a reservoir for pathogenic Leptospira spp. Under Swedish conditions leptospirosis gives rise to reproductive disorders in pigs and symptoms of flu in humans. It has long been established that rodents are chronic carriers of pathogenic leptospires in their kidneys, and can spread the bacteria with urine. The old nomenclature of serovoars is still in use, but a new system of genetic classification has developed and today the genus Leptospira contains 17 species. There are several diagnostic test developed for leptospirosis.

The aim of the project was to investigate if Swedish rodents, brown rat (Rattus norvegicus), house mouse (Mus musculus), wood mouse (Apodemus spp) and water vole (Arvicola terrestris) captured in pig herds and in urban areas, constitute a reservoir for pathogenic Leptospira spp. Under Swedish conditions leptospirosis gives rise to reproductive disorders in pigs and symptoms of flu in humans. It has long been established that rodents are chronic carriers of pathogenic leptospires in their kidneys, and can spread the bacteria with urine. The old nomenclature of serovoars is still in use, but a new system of genetic classification has developed and today the genus Leptospira contains 17 species. There are several diagnostic test developed for leptospirosis.

The aim of the project was to investigate if Swedish rodents, brown rat (Rattus norvegicus), house mouse (Mus musculus), wood mouse (Apodemus spp) and water vole (Arvicola terrestris) captured in pig herds and in urban areas, constitute a reservoir for pathogenic Leptospira spp. Under Swedish conditions leptospirosis gives rise to reproductive disorders in pigs and symptoms of flu in humans. It has long been established that rodents are chronic carriers of pathogenic leptospires in their kidneys, and can spread the bacteria with urine. The old nomenclature of serovoars is still in use, but a new system of genetic classification has developed and today the genus Leptospira contains 17 species. There are several diagnostic test developed for leptospirosis.

Syftet med denna uppsats är att försöka tolka ett eventuellt mönster av maskulina framställningar och ställa dessa tolkningar i relation till den äldre, mer traditionella bilden av mannen. Detta gjordes genom en studie av reklamfilm i svensk TV. Studien är en diskursanalys som utgår från ett analysschema vilket tagits fram med hjälp av Keith Selby och Ron Cowderys bok How to study television. Analysschemat är indelat i sex olika nivåer. Först och främst har urvalet utgått ifrån reklamer som har någon visuellt identifierbar manlig karaktär.

ABSTRACT Epilepsy describes a neurologically caused condition which involves seizures. Epilepsy can be classified according to different types of causes and the nature of seizures can vary. Medication for epilepsy in dogs is limited in comparison with human medicine. Idiopathic epilepsy is the most common neurological disease and one of the most common genetic diseases in dogs. Because epilepsy has a higher prevalence in certain breeds, there is reason to suspect that it is a hereditary disease. The inheritance of idiopathic epilepsy is for most breeds not determined, except for a few variants of the disease.

In Peru guinea pigs are raised for meat production and salmonellosis is considered as a major problem. Studies have detected salmonella in animals with enteritis and pneumonia. Salmonellosis exists both in an acute and a chronic form. In the rural areas the diagnosis is made according to clinical signs and macro pathological findings at autopsy. The major systems applied for the guinea pig production are often classified as family, family-commercial and commercial. These systems differ in number of animals and how industrialised they are.

Många av de europeiska järnvägsbolagen håller på eller har gått över till att använda GSM-R teknologi för kontakt med sina tåg och personal. Förut användes enklare sätt för att hålla kontakt med tåg, till exempel sändare nedgrävda längs rälsen och visuella tavlor. På det viset kunde tågen positionsbestämmas och föraren kunde kontaktas. När ett modernare system skulle byggas kom man fram till att GSM-R standarden skulle konstrueras. Vad innebär egentligen GSM-R standarden? Jo, det är en utbyggnad av GSM-nätet och opererar på frekvenserna 876 - 880 MHz och 921 - 925 MHz.

Emerging infectious diseases are a recurring threat to both human and animal health. Understanding the multiple causes behind the emergence of new diseases is key to the prevention of new and potentially devastating outbreaks. The list of underlying causes is long, including a variety of anthropogenic, environmental, molecular and climatic changes that promote the emergence and spread of disease. Two of these factors are central to the emergence of new diseases and receive special attention in this study. The spread of disease from wildlife to livestock and diseases that spread from animals to humans (zoonoses) are of importance as they implicated in the majority of EID events.