The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

In Sweden, reduced tillage usually means non-inversion tillage, where primary tillage is carried out using chisel ploughs or disc implements. Primary tillage method is mainly determined by the desired soil loosening and the handling of soil residues. The effect of tillage depth was studied in field experiments in Skåne, Väderstad, Uppsala, Örebro och Västerås in different crops; spring oilseed rape, spring wheat, winter wheat and spring barley.The experiments generally had a randomized block design with the treatments mouldboard ploughing, deep chisel ploughing and shallow chisel ploughing, in some cases also shallow discing and no-tillage. In the experiments the following parameters were determined: seedbed properties, saturated hydraulic conductivity, penetration resistance, number of emerged plants and crop yield (all parameters were not determined in all experiments. Root growth and draught requirement were determined in two separate studies. There were no significant differences between tillage depths in non-inversion tillage in seedbed properties, plant emergence or root development.

Several diseases increase the risk of thrombosis in dogs and cats, often with a fatal outcome. Currently there are no definite treatment guidelines for the use of thrombolytic and thromboprofylactic agents in veterinary medicine. None of these drugs are approved for dogs and cats in Sweden. Medicines aimed for humans have been used tentatively. This literature study is an investigation of what is currently known about the effects and safety of these pharmacological agents when used for dogs and cats.

Dag Wellander: Meaning ? memory: oblivion. A reading of Birgitta Trotzig?s The mud kings daughter. Master of Arts paper.

Food-poisoning is a major health problem and an estimated half a million Swedes are food-poisoned annually, with acute gastroenteritis as a consequence. One of the major causes of contaminated foods is related to food- and waterborne viruses. To be able to trace back the source of contaminant, the method of detecting viruses must be specific and sensitive. No standardized method for detecting foods for sapovirus exists today. The aim of the work described in this bachelor thesis is to implement and opti-mize a real-time RT-PCR method for the detection of all genogroups of human sapovirus in foods.

För att undersöka resursallokering av processresurser vid informations-bearbetning av hotstimuli har ett ?Dual Task? experiment utförts med spindelrädda försöksdeltagare. Uppgiften bestod av att respondera på olika probe-stimuli som exponerades, direkt på bilder av olika djur (däribland spindlar), med olika tidsintervall. Latens och träffsäkerhet mättes, för ett mått på prestation, och EKG användes för att kontrollera att spindel-bilderna faktiskt utlöste rädsloresponser. Resultaten visar att större processresurser allokerades till spindelbilderna jämfört med alla de övriga bildkategorierna, men att denna differentiering inte verkar ske innan en kognitivt kontrollerad bearbetning och utvärdering av stimulus ägt rum.

Rabies is a fatal zoonotic disease spread worldwide. The most common sources of infection for all animals and humans are bites from dogs or bats. The aim of this degree project was to diagnose and determine the source of infection for 11 rabies samples from São Paulo State and Minas Gerais State, Brazil. Diagnosis was made through direct immunofluorescence assay, mouse inoculation and RT-PCR. The sources of infection were determined by sequencing 234 nucleotides of the 5? end of the N-gene and align these with homologous sequences retrieved from GenBank.

The aim of this report is to describe the deglaciation in an area on west Greenland in the vicinity of Kangerlussuaq. To do this, the geomorphological landforms were mapped by studying areal photographs and by a two week field study where key areas were examiend. The landforms were transferred to a map using ArcGis and each key area were interpreted.The majority of the geomorphological formations were formed during the last deglaciation and consists of morain ridges, kettle topography in both till and glacifluvium, glacifluvial deltas, two fossil sandurs, and lateral terraces. Based on key areas and an inversion model a geomorphological map was created to illustrate the deglaciation, using the least complex explanation of the genesis of the landforms. The results show that the ice played a major role by damming lakes which enabled formation of many meltwater chanels and delta formations on higher elevations.

Att "smarta" brädspelande datorprogram har blivit mycket bättre under de senaste årtiondena har väl knappast kunnat undgå någon. Med brädspel menar jag spel såsom Go, Othello, Backgammon och Schack. Idag spelar program, som körs på en reguljär PC, bättre än de flesta människor. Vad är det som gör dessa program så bra? Hur kan man lära en dator att spela ett så pass komplext spel som Othello på en sådan nivå att ingen människa har en chans att vinna? I detta examensarbete kommer jag att försöka förklara mekanismerna bakom ett toppspelande Othelloprogram.

The area of Lycksabäcken northwest of Lycksele is a national interest of natural conservationbecause of its geological values with many unique landforms. Many of these landforms indicatethat the deglaciation process in the area was very complex. However, the deglaciation process inthe area has not previously been fully understood. The aim is to add to the knowledge of theevents that took place during the last deglaciation. To do this, the glaciofluvial landforms in thearea were mapped by studying aerial photographs with a Wild Aviopreter and a five-day fieldinventory of key areas for the interpretation.

In the following study I probe the social world of hard-rock music. By conducting interviews with four young male enthusiasts of this music I try to develop a general picture of this social world, as well as of the basic elements on which this particular subculture is constructed. The identity of a hard-rocker is based upon a number of factors beyond just a preference for that music. Throughout the interviews I encountered many implicit norms that one must followed in order to be able to see oneself as a true hard-rocker. I also found that from the respondents? perspective, the mainstream culture has, throughout the history of metal music, used various ways to counter the spreading of this genre.

During the work at Gateway Security AB in Motala I began examining available antenna models to get a wider perspective, this have given knowledge of their structure, and an understanding of their function. All my necessary fact is based on my observations and notes of these measurings. New antenna models, and available models were examined where measurements at different heights and different distances on the antenna were performed with the help of an oscilloscope and a measure probe, peak ? to - peak was brought on the signal. The measurements are presented in a line diagram.

This review article presents the splicing process during messenger RNA maturation and how it is regulated by different Cis-regulatory RNA-sequence elements and splicing factors. A more detailed description of the process alternative splicing and its importance to the function of genes from the model organism Arabidopsis thaliana is also given. A single eukaryotic gene can by the process alternative splicing (AS) give rise to a number of functionally mature mRNA-molecules, which in turn encodes for structurally and/or functionally different proteins. During the course of evolution, the process alternative splicing has thus shown to be effective in increasing transcriptome and proteome diversity of most eukaryotic organisms. This suggests therefore that the dominant theory in molecular biology, a gene encodes for a protein, needs to be corrected.

The purpose of this study was to look into how learners of Swedish as a second language and some teachers of the subject think and reason about the choice between Swedish or Swedish as a Second Language and literature in Swedish at upper secondary schools. Similar studies have earlier been carried out at upper secondary schools in areas dominated by immigrants while the present study has been accomplished in a small municipality with comparatively few immigrants. The study is based upon qualitative interviews which have been analysed through the socio-cultural theory regarding those artifacts, communication and that mediating second learners of Swedish and their teachers and schools are using in their choices between Swedish or Swedish as a Second Language as well as selection of literature in literature teaching.  The study also shows how learners of Swedish as a second language perceive the choice between the two options of Swedish courses at advanced upper secondary school and how their teachers look upon their choice and the information given. Furthermore we will also get to know the learners of Swedish as a second language and their teachers? view on teaching Swedish literature at advanced upper secondary B-level in Swedish.