Today the individual ventilated cage system (IVC-system) is a commonly used housing system for mice in research facilities. IVC systems have HEPA- filters and are designed to control both supply and exhausted air at cage level, as well as temperature and relative humidity in the cages. This creates an optimal environment for the mouse and at the same time a protection against the risk of cross-infection between cages and the outside environment. The aim of this study was to evaluate the health and welfare of breeding females and pups of two different strains of laboratory mice (NMRI nude mice and C57BL/6N) in three different kinds of IVC-systems; Arrowmight, Allentown and Tecniplast. The NMRI nude (Nu) females gave birth to 18 litters in Allentown, 16 litters in Arrowmight and 15 litters in Tecniplast.

Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

The intention of this study is to investigate possible excitation on dogs due to buprenorphine treatment. The reason for it to be about buprenorphine and not any other opioid is due to its relevance being one of the most popular opioids in animal care, as well as the authors own experience with what seems to be buprenorphine induced excitation in her own dog. The study consists of a literature review and an internet based survey containing thirty questions sent out to twelve animal clinics and animal hospitals. Significant agitative effects on behavior has been found in studies on horses, sheep, goats, rats and mice, but no one shows the effects of buprenorphine on dogs. The literature on opiod effects on dog behavior seems sparse.

Kollisionen mellan två standardavtal benämns battle of forms och frågan blir om det finns ett avtal mellan parterna och vilka villkor som ska reglera parternas förpliktelser. De faktorer som anses vara av vikt är att lösningen bör vara förutsägbar, den ska innebära att parterna har en fortsatt avtalsrelation till varandra, den bör lösa tvisten snabbt och effektivt samt att den bör ta hänsyn till parternas egna krav och önskemål. Den svenska avtalslagens regler om oren accept innebär ett avtalslöst tillstånd mellan parterna och den svarar inte på vilka villkor som ska reglera avtalet. The last shot enligt art. 19 CISG innebär att det sist översända standardavtalet bli gällande på avtalet.

This thesis deals with the numerical 3D simulation of a four stroke, spark-ignited, internalcombustion engine, which is mounted on a high performance motorcycle. The work, carried outin collaboration with Politecnico di Milano and MV Agusta, focuses on the simulation of theintake, compression and expansion stroke, including combustion simulation, using an opensource CFD code.Simulation of internal combustion engines offers a great challenge in the field of CFD research.Moving boundaries of the solution domain, caused by the motion of the piston and valves, leadsto deformation of the computational grid, with decreasing quality of the solution as result. Basedon this, a previously developed mesh motion strategy was employed where a number of meshesare used to cover the whole simulation cycle. Within each mesh interval the internal cell pointsof the mesh are moved to account for the boundary motion of the piston and valves. This strategywas previously applied to simplified geometries as well as real engine geometries.

AbstractThe use of standard agreements can hardly be overestimated in the society of today. The amount of standard agreements should barely decrease. One of the standard agreement?s main purposes, to make the concluding of the contract more effective, strongly agrees with the companies will to accomplish fast concluding of agreements using as small resources as possible A dispute that can arise in these contexts is that dissimilar standard agreements collide. Between nations this is called Battle of Forms.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Counter-Strike has established itself as one of the most popular computer gaming phenomenon the last decade with a major online community and loyal fan base. Within the world of e-sports it has also become one of the most lucrative games to compete in. In order to keep up with the competition it has always been important to use the best hardware available for the task. This thesis is about these tools that gamers use to play - gaming gear - and how pro gamers train to increase their chances of winning. We investigate various factors that might be important in their choice of gaming gear when they play, and how they train to use these artifacts more efficiently to get maximum performance.

Sommaren 2014 blev det tillåtet att bygga en komplementbyggnad på 25 kvm utan att behöva söka bygglov. Denna byggnad är möjlig att inreda för permanentboende. På grund av den höga bostadsbristen var tanken från regeringen en möjlighet till uthyrning till unga vuxna som studerar eller vill flytta hemifrån. Det som behövs för att bygga en komplementbyggnad på tomten är att lämna in en bygganmälan och sedan invänta ett startbesked. En bygganmälan kan kosta olika beroende på i vilken kommun den sökande tänkt bygga.

The WT1 gene is a complex gene originally known to suppress cancer in kidneys. Studies of WT1 knockout mice have confirmed the important role of WT1 in the pathogenesis of Wilms? tumour, a tumour which counts for 95% of all childhood renal tumours. In that case the WT1 gene acts as a tumour suppressor gene. Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, e g in leukemia or lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors).

Since events of September 11 and the subsequent conflicts surrounding the event, the war against terrorism has been constantly present. It has been used several methods and strategies to address these threats, including a method current in use, the targeting method. The method refers to use few but precise attacks to knock out key functions within these organizations, mostly individuals in the higher command and control structures within these organizations. The effectiveness of the method has been put in question when the majority of the terrorist organizations continue their strife, in some cases even increasing its intensity. The purpose of this study is to investigate which role the higher command plays in these organizations ability to wage war.

Denna uppsats behandlar frågan om kolliderande standardavtal, internationellt benämnt battle of the forms. Problematiken grundas i att två parter i en avtalsförhandling har tillsänt varandra olika standardavtal med motstridiga villkor. Tvist uppkommer sedan oftast när parterna börjat prestera eller till och med fullbordat avtalet. Frågan uppkommer då vilka villkor som skall gälla samt hur denna problematik bör lösas. Eftersom problematiken är sparsamt utredd i svensk rätt har vi valt att studera tre nationella och tre internationella rättskällor och regelverk för att söka ledning i frågan.

Nathalia Edenmont is a controversial and uncompromising photo artist who has caused the whole world to rage over her obscene photographs. In this thesis I have researched Edenmonts artistry with help of the sociologist Pierre Bourdieus field analysis. By using Bourdieus's different field concepts I have researched Edenmonts artistic career by concepts such as habitus, consecration and different principles.The starting point of this research has been that Nathalia Edenmont is in the autonomous artistic field. I give examples of images that have been highly debated and I have collected information of how Edenmont sees her own images and her artistry. In this thesis I show amongst other things an example with Edenmonts photograph of dead rabbits with Elizabethan hair styling, cut up mice that work like finger puppets and children who are bound up in wire.Nathalia Edenmont autonomous artistry is deeply rooted in her background and the environment in which she was raised.