In the end of the 80´s the area of system development moved into a new era. As a consequence many new methods and development models emerged which in many cases resulted in problems when choosing system development models and methods. As a result of these problems the today standardized modeling language UML (Unified Modeling Language) was created. UML is tailored to support many different types of projects. This is possible because of UML?s capacity to be adjusted and adapted to a specific company environment.The purpose of this bachelor thesis is to investigate how and why companies use UML and what experiences and opinions those who use UML have of using UML in practice.

Uganda has the largest pig population in east Africa, and most of the animals are owned by smallholders. Infectious diseases among pigs have a devastating impact on the livelihood of these farmers, which are dependent on the proceeds from pig rearing. In a metagenomics study of the wild pig species bushpig (Potamochoerus larvatus), the porcine viruses Torque teno sus virus (TTSuV) 1and 2 and Porcine parvovirus 4 (PPV4) were detected. TTSuV1 and 2 are ubiquitous in the world?s swine population, and PPV4 has been found in USA and China, but neither of them has been studied in Africa previously.

The ability to detect protein-based biomarkers, which are linked to different diseases like colorectal cancer, is very important as a diagnostic tool. Usually complex biological samples like blood are studied which will contribute to different technical issues when performing an assay. The aim with the project is to optimize and develop the high throughput protein detection technique Proximity Extension Assay, PEA, into a 96-plex panel, in hopes of discovering an expression profile for colorectal cancer. PEA was developed by Olink Bioscience and allows specific proteins in a sample to be quantitatively transformed into nucleic acid sequences that are subsequently detected and quantified with real-time PCR. Two proximity probes containing oligonucleotide sequences bind pairwise to target protein and when brought in proximity, a DNA polymerase will extend a hybridization arm from one probe over to the second forming a double-stranded DNA sequence that can serve as a template in real-time PCR.

It generally takes 10 to 12 years for a new drug to hit the market. The pharmaceutical industry invests huge sums in these early stages of research and development. In spite of the rapidly rising research and development expenditures fewer and fewer blockbuster drugs are being developed. Longer lead times and aggressive generic post-patent competition have narrowed the timeframe for the pharmaceutical companies to profit on their investments.In the face of these threats the pharmaceutical industry has developed a battery of strategies to prolong market exclusivity and to maximize return on investment. These emerging strategies are commonly known as Life cycle management (LCM), which actually is more of a concept than a method.

AbstractThe genetic diversity in cultural plants is considered to be threatened due to global climate change and antropogenic influence. Unknowing of future conditions for cultivation, gene banks all over the world are now trying to build up costly safety nets of species and varieties that may become highly valuable owing to their specific traits and genetic heredity. Hence, in 2002 there was a national inventory, aimed at the Swedish public, asking for seeds believed to be lost. Among the resulting collected seeds were some accessions of garden bean, Phaseolus vulgaris. The objective of this particular study was to assemble a collection of unique varieties and discard possible duplicates.

Cardiac troponin I (cTnI) is considered a specific and a sensitive biomarker of cardiac disease, and due to a high inter-species sequence homology; human cTnI assays can often be used in veterinary medicine. The main aim of this study was to perform an initial evaluation of a human cTnI test, the Meritas Troponin I test, for measurement of equine plasma cTnI, in order to investigate whether the test could be a possible subject for a more comprehensive validation. The hypothesis was that the test could measure equine cTnI, as there is a good homology between equine cTnI and human cTnI. The evaluation included a dilution parallelism, an intra-assay precision study and measurement of plasma cTnI healthy horses. In the dilution parallelism and the intra-assay precision study, equine plasma with previously established high cTnI concentration, according to another cTnI assay, was used. In addition, cTnI concentration was measured in plasma, collected from 19 horses, without signs of disease at physical and ECG examinations. The obtained curve in the dilution parallelism was linear, indicating that the Meritas Troponin I test can be used to measure different concentrations of equine cTnI in plasma.

A distributed hydrological rainfall-runoff model has been developed using a GIS integrated with a dynamic programming module (PCRaster). The model has been developed within the framework of the EU-project TWINBAS at IVL Swedish Environmental Research Institute, and is intended for use in WATSHMAN ? a tool for watershed management developed at IVL. The model simulates runoff from a catchment based on daily mean values of temperature and precipitation. The GIS input data consist of maps with soil type, land-use, lakes, rivers and a digital elevation model.

As the contemporary discourse surrounding urbanism is almost exclusively focusing on aspects of density and traditional urban qualities, it entrenches notions of what constitutes a proper city and countryside. But beyond this urban-rural dichotomy is another highly contemporary landscape. A territory usually mentioned as sprawl, peri-urban, wasteland, edge city, etc. Although its existence is due to mobilization, telecommunications, globalization and other phenomena of modern life, it is a landscape without an own name or place in public awareness.This thesis provides a case study of how to map and intervene in such a landscape, specifically along the border between Malmö and Burlöv municipalities in southern Sweden. Its structure is composed of a sequence of three parts:1 Spatial Conditions:Divided up in the sections Network, Fringe and Void.

Cassava (Manihot esculenta Crantz) is a root crop that plays an important role in many households in Africa. It is sometimes called ?Africa´s food insurance?. The advantages with the crop are that cassava is drought-resistant and it can grow in a semi-dry land. It is a perennial crop and does not require much labor.

In Swedish sheep industry it is desired to have lambs slaughtered evenly distributed over the year. Swedish sheep are generally seasonal breeders with lambs born in the spring and slaughtered in the autumn. Some of the breeds, e.g. Swedish Finewool and Roslag sheep breeds have shown ability to lamb out of season. For increased knowledge on the possibilities to breed for out-of-season lambing in Swedish sheep breeds, the aim of this master thesis is to study the variation in frequency of two alleles in the MTNR1A gene in the three breeds; Gotland, Swedish Finewool, and Roslag sheep.

AimThe aim of the study was to develop a method for the survey of play movement demands and temporal patterns in order to enable a descriptive study of the defensive players in American Football. The overall aim was to  improve the understanding of how American Football is played to create opportunities for enhancement of current or developing new training methods to better suit football.MethodFifty plays from a Division 3 college football game on video from 2005 was divided into sequences of action for one player each from the defensive line, linebackers and defensive backs and analyzed with the video analyzing software cSwing. Every players sequence of action was recorded in a spreadsheet and noted on a scaled football field where distances were measured and together with time stamps from cSwing velocity was calculated.ResultsUsing this method it was possible to describe the play movement demands and temporal patterns which was the main task of the study. The defensive end worked on an average 4.61 seconds per play, the distance was 12.4 meters and average speed 2.5 m×s-1. The linebacker worked on an average 4.35 s per play, 13.7 m and at a mean speed of 3.0 m×s-1.

This Master Thesis has been conducted as an assignment of the Swedish Defence MaterialAdministration and the Swedish Armed Forces and aims to examine the Target Location Error(TLE) of a Forward Observer System. The targeting accuracy of the system is vital if the systemis to be used as a sensor for precision munitions. The analyzed system, EOI (FOI 2000), wasdelivered to the Swedish Armed Forces in 2007. The targeting sequence starts with deciding theposition of the system with a GPS-receiver, continues with methods where the north direction issettled and ends by measuring the distance, direction and elevation to the target. When allparameters have been measured the system calculates the position of the target.

Nätverks-RTK (Real-Time Kinematic) är en metod för positionsbestämning med Global Navigation Satellite System (GNSS) i realtid. Metoden kräver att en driftledningscentral kan kommunicera med de GNSS-mottagare som använder referensstationsnätet, för att bland annat skicka ut korrigerade GNSS-data. I Sverige erbjuder SWEPOS, ett nät av fasta referensstationer, en tjänst för nätverks-RTK-mätning, som förväntas ge en mätosäkerhet på mindre än 15 mm i plan och 25 mm i höjd (över ellipsoiden) (med täckningsfaktorn k = 1 i bägge fallen). Den teknik som idag används av SWEPOS för att utföra positionsbestämning av GNSS-mottagare är Virtuell Referensstation (VRS). VRS kräver tvåvägskommunikation eftersom mottagaren skickar in sin absoluta position till nätverks-RTK-programvaran hos driftledningscentralen, var beräkningarna av korrektionsdata sker, innan de skickas tillbaka till mottagaren.

The voltage level in the power grid varies due to variations in load and production. Normally these variations are manageable, but they may be excessively large during a disturbance. If the voltage is too high it may damage the equipment in the grid and too low voltages may cause problems like voltage instability. The magnitude of the voltage variation depends on the short circuit power capacity of the point of interest.This problem may become lore prominent due to automatic voltage regulation that acts on shunt reactors and shunt capacitors. When the shunt reactor is connected or disconnected to the grid it may cause such large changes in the voltage that the shunt reactor starts hunting.

AimThe aim of the study was to develop a method for the survey of play movement demands and temporal patterns in order to enable a descriptive study of the defensive players in American Football. The overall aim was to  improve the understanding of how American Football is played to create opportunities for enhancement of current or developing new training methods to better suit football.MethodFifty plays from a Division 3 college football game on video from 2005 was divided into sequences of action for one player each from the defensive line, linebackers and defensive backs and analyzed with the video analyzing software cSwing. Every players sequence of action was recorded in a spreadsheet and noted on a scaled football field where distances were measured and together with time stamps from cSwing velocity was calculated.ResultsUsing this method it was possible to describe the play movement demands and temporal patterns which was the main task of the study. The defensive end worked on an average 4.61 seconds per play, the distance was 12.4 meters and average speed 2.5 m×s-1. The linebacker worked on an average 4.35 s per play, 13.7 m and at a mean speed of 3.0 m×s-1.