The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

This paper contains an analysis that sets out to investigate how sustainable development is portrayed in textbooks used in gymnasium level civics education. The study covers three textbooks, all in current use. The paper sets out to explore the relationship between the books chapters on economics and those about environmental issues. The sum of these two parts is in the context supposed to make up the books big picture of green sustainable development, i.e. the ecological aspect of sustainable development. An analytical model will be used to categorise and compare the three textbooks.The method chosen for this is analysis of ideas by use of ideal types.

Flexicurity is a union of the English words flexibility and security. The union of the two words to one common term, hints that flexibility and security does not have to be each others counterparts in order to achieve good economical development and employment. Flexicurity, as it is found in Denmark, is described as a three part model composed of active labour market politics, generous financial compensation in the case of unemployment and flexible labour law. The existence of strong collective agreements and three part cooperation is of great importance for the good flow of the Danish model. The same goes for education of different kinds.

The purpose of this thesis work was to develop an automatic fault detection system for surveillance of bearing temperature in hydropower turbines. The parameters used except the bearing temperature were cooling water temperature and cooling water flow. A simple static model based on data sampled every minute was developed to estimate the bearing temperature. Then a detector for detection of change in bearing temperature based on the CUSUM-algorithm was designed. Since the amount of data was very small the developed model was too uncertain to be used in a working system.The designed fault detection system showed to work well for the available data.

We have carried out a study of a classification system for the Swedish collection at The Royal Library in Stockholm from 1887. It was printed in 50 copies. The constructor, Bernhard Lundstedt, and his colleagues used it as guidance in lack of a catalogue. We regard it a local classification system. Little research has been done on old classification systems, but Francis Miksa points out the importance of examining them.

This degree project deals with the creation of a business system for Gamersneed Sweden. The system is divided into two parts, one windows appliction and one websolution..

Pharmaceuticals are environmental pollutants that are a major threat to aquatic ecosystems and very little is known about their ecological consequences. In this study growth, survival and behaviour (sociability, activity and boldness) of perch fry (Perca fluviatilis) were examined in order to study the possible effects of exposure to a benzodiazepine anxiolytic drug, Oxazepam, during embryonic development. The study tested following hypotheses: (1) perch growth is affected positively by exposure during embryonic development; (2) early perch survival is affected positively by exposure during embryonic development; and (3) boldness and activity increases while sociability decreases in perch fry exposed during embryonic development. Embryos of naturally spawned perch were exposed to water with two different concentrations of Oxazepam. The embryos were exposed during different parts (24-hour periods) of the embryonic development, because embryos may be more vulnerable at certain times during embryonic development and/or because the exposure at different times can produce different effects.

The goal of this Masters thesis is to examine how people at the production department of Arkivator Falköping AB perceive the internal organisational communication transfer and exchange of information, by means of a communication audit. The objectives are also to characterise the communication climate and the respondents satisfaction with the internal organisational communication within the organisation. The results of the study are compared with the companys information policy and with previous research in organisational communication. Answers from different demographic groups within the population are compared. The communication audit was conducted using a modified and added version of a questionnaire originally compiled by the International Communications Association.

This Master of Science thesis was completed at the Department of Machine Design at the Royal Instituteof Technology in Stockholm in collaboration with Lund Faculty of Engineering, Luleå University ofTechnology and Stanford University. At Stanford University a global product development project wasrealized as part of the course ME310. The project was initiated by the American company ImmerseGlobal whose vision was to develop a new type of Atmospheric Water Generators, a machine that absorbsthe moisture in the air and via a water system transforms it to pure drinking water. The project was partlyfinanced by the Product Innovation Engineering program, a Swedish research and development programfor increased innovation capability in organizations.In parallel with the global project in the ME310 course the product development process was studied inorder to compare it with a product development course at the Royal Institute of Technology, IPU. Thetwo courses are similar to each other in several aspects.

Problem: What are the characteristics of Polykemi?s management control system and how is it affected by growth? Purpose: To describe and analyse the management control system of a medium-sized family-owned company from the perspective of Simons? Levers of control. Research design: An abductive, interview-based case study of Polykemi AB. Conclusion: Polykemi?s management control system is primarily a traditional one which is rather strong in terms of Levers of control.

Design for Six Sigma (DFSS) is a further development of the Six Sigma draft to carry through preventing quality measures in developing and designing of new products and processes. With increasing demands on enterprises development processes to be more safety and faster the need of DFSS arise as a product, process and service development concept in the organisations. Design for Six Sigma aims to improve and structure the development process of an organisation and consider the application of the innovation problem solving. The concept aims to leave the structure of the traditional Six Sigma concept and instead, from an innovative perspective, search for new solutions to existing problems. The concept constitute of a toolbox with a lot of quality tools that are divided into phases in a development model.

AbstractSeveral of researchers have reflected that the school ought to be developed to a learning organization. A method as proceed from such a perspective and should be able to match a local child- and educations administration is problembased school development. To investigate in which ways a child- and educations administration prosecute a problem based learning inside the organization a case study was used as research strategy. The question this report gives answer to is:In what/which way works a child- and educations administration in a rural district with a method to fulfil a problembased learning.To collect empiric data a canvassing inquiry was accomplished among the child- and educations administrations group of management. According to the research result it can declares that there are good conditions for the organization to prosecute problem based school development, but there is yet a great deal to do before it´s can be said totally fulfilled.

In January 2005 the emission allowance system was introduced within the European Union and the first period ends at the end of 2007. The system was introduced in order to decrease the wastes of carbon dioxide and the system is a part of ratifying the Kyoto ?protocol which first period runs between 2008-2012.The idea of the system is to reduce the wastes of carbon dioxide where it costs less to do so and the expenses for the society therefore are as diminutive as possible. Different theories explain that companies can benefit from environment legislation and can depending on the company?s attitude gain competitive advantages improve its productivity and thereby increase its profitability.With this in mind, the study aims at examining how the introduction of the emission trade system has influenced Swedish smaller companies in the distant heating industry, with focus on the factors attitude, innovation, competition and profitability.

A power system will inevitably be subjected to transient overvoltages, most often produced by switching operations and lightning strikes. These transient overvoltages may harm sensitive equipment without sufficient protection, but it is not an easy task to predict what transients may occur or how they affect the system. A fault occurred in a low voltage system at Forsmark 2012 and overvoltages from lightning were concluded as the probable cause. The three aims with this thesis are to develop and test a model of the power system at Forsmark 3, analyse the transient behaviour of the system when subjected to lightning surges and identify critical parameters, and lastly to provide a tool for investigating the protection of the system. The modelling and simulations were performed in the freely available simulation program LT Spice.

Systemintegration är arbetet med att få IT-system att samarbeta med varandra. Inomsystemintegration finns det idag ett glapp mellan den tekniska dokumentationen och den tekniskalösningen vilket försvårar arbetet med att ta fram och underhålla integrerade system. För att underlättadetta skapades på uppdrag av Ipendo Systems en databasmodell för att kunna lagra tekniskdokumentation om integrationssystem. Lösningen implementerades i Microsoft SQL Server. Underarbetet utvecklades stöd för hämtning av data från integrationsplattformen BizTalk.