The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

The Swedish government published their current proposition concerning cultural politics,Tid för kultur in 2009. Due to this proposition, culture is considered a basic human right we all deserve to be provided with. It contained goals and guidelines for how to enable culture to all citizens, to integrate and enrich the state, the county councils? and municipalities? work with diversity and multi culture in their culture-based institutes. However, there seems to be a lack of strategies in the issue of how to provide our nondependent elderly, suffering age related handicaps and diseases, with this proclaimed necessity.In recent years, there has been a lot of research proving the link between human wellbeing and a stimulating environment.

The Swedish government published their current proposition concerning cultural politics,Tid för kultur in 2009. Due to this proposition, culture is considered a basic human right we all deserve to be provided with. It contained goals and guidelines for how to enable culture to all citizens, to integrate and enrich the state, the county councils? and municipalities? work with diversity and multi culture in their culture-based institutes. However, there seems to be a lack of strategies in the issue of how to provide our nondependent elderly, suffering age related handicaps and diseases, with this proclaimed necessity.In recent years, there has been a lot of research proving the link between human wellbeing and a stimulating environment.

The occurrence of small amounts of albumin in urine, microalbuminuria (MA), is used both in human- and veterinary medicine as an indicator for patients who have developing proteinuria. Proteinuria can be prerenal, renal or postrenal which is important to establish during an investigation. With conventional methods decreased renal function is not detected until 70 % of renal function is lost. The ability to detect and start a treatment earlier might reverse or slow the progression of disease. The purpose of this study was to investigate the reliability of Heska® E.R.D.-Health Screen?, a test for microalbuminuria in dogs, to detect albuminuria.

Bakgrund: Ca 10% av alla nyf?dda i Sverige v?rdas ?rligen p? en neonatalv?rdsavdelning, d?r separation mellan barn och f?r?ldrar ?r vanligt f?rekommande, trots evidens om dess negativa konsekvenser f?r b?de f?r?ldrar och barn. Nollseparation inneb?r att f?r?ldrar och barn h?lls i s? mycket fysisk och psykisk n?rhet under v?rdtiden som m?jligt. ?ven om tidigare forskning har belyst konsekvenserna av separation inom neonatalv?rden, finns begr?nsad sammanst?lld kunskap om hur f?r?ldrar upplever nollseparation i en neonatal kontext.

Svår sepsis och septisk chock är sjukdomstillstånd som kan orsaka ett stort lidande för patienten genom att de är förknippade med hög mortalitet och morbiditet. Tidig identifiering och adekvat antibiotikabehandling är avgörande för prognosen. Detta ställer höga krav på ambulanssjukvårdens kvalitet. Ambulanssjukvården har behandlingsriktlinjer som ska utgöra beslutsunderlag och kvalitetssäkring för den givna vården. De potentiella vinsterna med en behandlingsriktlinje blir dock aldrig bättre än kvaliteten på behandlingsriktlinjen i sig.

It is important to know what is normal in the wound healing process in order to determine what happens when a wound does not heal as expected. If the amount of bacteria in the wound gets too large the body will not be able to defend itself and it becomes an infection. Colonization and infection are common elements in wound management and it is often the veterinary nurse role to deal with wounds in a proper manner. Antibiotics are drugs that either kill or inhibit the multiplication of bacteria or fungi, and have been in veterinary medicine for approximately 60 years. Very few new antibiotics are introduced and increased resistance is a major problem that requires everyone to take responsibility to reduce the use of it.

Penicillin G (benzylpenicillin) is the most commonly used antimicrobial substance used in equine medicine today. Two forms of penicillin G are available for equine use; one form is the poorly soluble penicillin G procaine and the other is the very soluble sodium salt. Although penicillin has a wide safety margin and is considered to possess a good tolerance, reactions due to side effects are sometimes encountered, which commonly is named ?penicillin-shock?. The etiology behind penicillin shock in horses is not completely understood, but the most common reason is believed to be procaine toxicity.

Föreliggande systematiska litteraturstudie syftade till att klarlägga vilka omvårdnadsbehov som föreligger hos patienter med typ 2-diabetes. Sammanlagt 15 vetenskapliga artiklar valdes ut via sökmotorn Electronic Library Information Navigator (ELIN), databasen Cumulative Index of Nursing and Allied Health (CINAHL) samt sökmotorn och databasen för medicinska artiklar som drivs av United States National Library of Medicine (MEDLINE), för vidare granskning. Sökorden type 2 diabetes AND quality of life AND nurs* användes. Alla titlar lästes, om titeln verkade relevant för forskningsområdet lästes även abstraktet. Kvalitetsgranskning av artiklarna genomfördes efter granskningsmallar med 28 bedömningskriterier.

Bakgrund: Evidens styrker att teamrehabilitering är en lämplig rehabiliteringsform för patienter med reumatiska sjukdomar. Gruppträning har i tidigare studier visat goda resultat för personer med reumatisk sjukdom. Dock är forskning om den subjektiva upplevelsen av gruppträningen bristfällig.Syfte: Syftet med studien är att ur ett socialkognitivt perspektiv undersöka vilka upplevelser och erfarenheter deltagare med reumatisk sjukdom fått av den gruppträning som ingår i teamrehabiliteringen.Metod: Studien har en kvalitativ design med induktiv ansats. Semistrukturerade intervjuer utfördes. Fem deltagare inkluderades och det insamlade materialet analyserades genom en kvalitativ innehållsanalys.Resultat: Det framkom att deltagarna hade en positiv uppfattning om teamrehabiliteringen och att de tog med sig många erfarenheter därifrån.

The purpose of this study was to examine the controversy surrounding the Swedish methadone assisted rehabilitation program over time. Which course has the Swedish methadone assisted rehabilitation program, and the controversy surrounding it, taken since the start? Which arguments have been for and which have been against a methadone assisted rehabilitation program in Sweden, and what are these arguments based on? We chose to write this thesis as a literature study to get a broad and in depth picture of the development of the program in Sweden. In our analysis we used social constructionism and a medical aspect on substance abuse as theories.It is clear that it has been, and still are, differences in opinions when it comes to the effects of the program. As early as in the 1980's the methadone assisted rehabilitation program was scientifically proved effective and approved by the Swedish Board of Health and Social Affairs.

When a person arrives at the emergency ward at the Uppsala University Hospital with his or her symptoms he or she explains the problems and then a priority process starts. The staff evaluate at which emergency level the patient is located in a model called Triage. The Triage model helps to decide the priority need and is based upon templates which point out in which of the 5 categories a patient is to be placed, to eliminate any future risk regarding his or her health. A lower triage level means lower priority but implies better health when the evaluation takes place. To obtain optimal effect of the Triage model the evaluation of symptoms must be reproducible so that patients with the same symptoms are placed at the same triage level regardless of whom among the staff conducts the evaluation. The purpose of the study was to see if the resources are allocated based on priority level of the patients.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Breakfast and cognition from a youth perspectiveAuthor: Linn Kruse and Anneli HulldinSupervisor: Anna WinkvistExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 26, 2014Background: Breakfast as an influencing factor on cognition and is often on the table for discussion in society. A lot of research has been done about how omitting breakfast affects adolescents and their short time cognition. Cognition is complex as a concept and is measured in different ways and the existing research in the area often compares different types of breakfasts instead of the difference between eating and omitting breakfast.Objective: To evaluate the scientific evidence for an association between adolescents? breakfast eating and short time effects on cognition in adolescents.Search strategy: To find relevant articles a systematic literature search was made in the databases PubMed, Scopus and Cochrane. Search terms that were used were: children, young adults, adolescents, cognition, and breakfastSelection criteria: Ages 12-20 years, measures cognition, RCT, studies comparing breakfast eating with omitting breakfast, human studies, language English or Swedish, no sick adolescents or adolescents with diagnosis.Data collection and analysis: Two original articles met the inclusion criteria and were reviewed by the SBU audit template for RCT studies.

AimThe aim of this study was to find out how the research that has changed CPR training developed from a historical perspective. The question at issue was: When the recommendations for chest compressions/ventilation, defibrillator and education have been changed, what kind of research led to the development?MethodTo fulfill the aim of this study we chose a review process. First we read the international guidelines for cardiopulmonary resuscitation (CPR) published by the American Heart Association (AHA), from year 1980 until year 2010. Secondly we chose the most important changes that had been made within the issues we had selected, then we examined the research that had supported these issues.

Scholarly publishing has since the introduction of electronically distributed periodicals seen a time of change, mainly in the STM-business (Science Technology and Medicine). The roles of the three main participants in the publication process; researcher, publisher and library are developing into new directions. Researchers themselves are taking a more active part in the discussion, with the boycott list from the Public Library of Science organization as an illustrating example. Reforms are being launched partly as an economical and efficiency issue, partly as an increasing desire from researchers to maintain the control of scientific end result. This Master s thesis examines how the partly conflicting goals of the participants affect the conditions for scholarly publication in an electronic environment.