Aortic insufficiency is a very common valve problem in horses and most often affects older individuals, but nevertheless existent within younger ones. The root cause for aortic insufficiency can be varied, for example; endocarditis, ventricular septum defect or congenital valve disease but the most common are progressive valve degeneration or elite competition. Depending on the root cause, different changes can be observed on the aorta valves, but they do all have the same effect, the valves do not seal properly and blood leaks backwards. Many horses can, even with this deficiency, perform highly without any visible impacts and there is therefore no need to treat those subjects. Most often the symptoms arise at a later stage in life and they are, more often than none, put down for other reasons. In the occurrence of the clinical symptoms showing, treatment guideline is to inhibit these symptoms since the valve degeneration is presently irreversible.

The objectives of this study was to examine the prevalence of hypertrophic cardiomyopathy in a family of British Shorthaircats to determine the mode of inheritance and to investigate if the disease was associated with a mutation in myosin binding proteinC (MyBPC3). The family comprised 28 cats, seven male and 21 females. The cats underwent a physical examination, including cardiac auscultation, and an ultrasound examination. Blood was collected for DNA- analysis. The blodsamples were sent in a buffer solution to Kathryn Meurs, Washington State University, USA for analysis, where the genes coding for MyBPC, Troponin I and T were characterized using microsequencing technique. Out of the 28 cats, 8 were diagnosed with HCM, 2 were diagnosed with congenital heart disease but had no evidence of HCM.

A number of studies have been made to examine several aspects of voice production in individuals with different types of hearing impairments. Most of the studies were made to explore the impact that hearing aids have for people with severe or congenital hearing impairment. So far it has been confirmed that there are changes regarding voice production in these individuals. A group that has not been investigated regarding voice production to a larger extent are hearing aid users with an acquired hearing impairment. In the present study the voice production of seven individuals, four men and three women, with a moderate acquired hearing impairment is examined.

The aim of this study was to examine young men born between 1990-1995 with anorectal malformations (ARM) whom have undergone the new PSARP-operation starting in 1990, and how they experience their psychosocial and sexual health. The study also examines how they cope with their life situation and what their experience is of the health care and how they were responded to through out the years. This study is a qualitative research and consists seven semi- structured interviews with young men between sixteen and twenty years old. The analyses of this material resulted in three themes around which the study centers: psychosocial health, sexual health and the medical establishment and the informants thoughts about the proposition of counseling for themselves and other individuals born with ARM. The study shows that these young men have a good psychosocial health and a likely reason for that is good parental relationships and close friendships.

Rhodesian ridgeback is a dog breed that originates from southern Africa. The characteristic ridge (a dorsal ridge where the hair grows in the opposite direction to the general coat) is shared with an Asian breed, Thai ridgeback. The origin and inheritance of the ridge has been examined and defined. The ridge-mutation is a duplication that contains four complete genes, FGF3, FGF4, FGF19 and ORAOV1 and the 3´-end of CCND1. The ridge is inherited as an autosomal, dominant trait and predisposes for Dermoid sinus (DS), a disease that develops during embryogenesis.

Renal dysplasi (RD) is a congenital chronic renal disease affecting young dogs. It is a rather common disease that occurs in a large number of dogs and in some breeds there is a familiar incidence or suspected hereditary background. Both the etiology and pathogenesis are still unknown, but a theory about the cause of RD is that the two components that form the kidney, the uretheric bud and the metanephrogenic blastema, don´t interact normally in the embryo. Kidneys affected by RD contain fetal (immature) structures that are inappropriate for the state of development/age of the dog and abnormal structures caused by an abnormal differentiation. Affected dogs usually are under .

Bakgrund: Effektiva marknadshypotesen innebär att det inte går att utnyttja systematiska avvikelser på marknaden. Trots det finns det etablerade investeringsstrategier som investerare använder sig av för att generera överavkastning.Syfte: Syftet med studien är att undersöka huruvida det går att generar överavkastning genom att investera i företag som uppvisar en låg eller hög EV/EBITDA-multipel. Variablerna bransch och risk kommer även att undersökas med utgångspunkt från den eventuella förekomsten av en investeringsstrategi som genererar överavkastning.Genomförande: Teori inom området har byggt upp en grundförståelse för problemet, empiri har sedan hämtats från de olika företagen för att få fram EV/EBITDA-multiplar till de ingående portföljerna i studien. Aktiekurser har även inhämtats för att bygga grunden till empirin. Resultatet har sedan jämförts med OMXSPI samt med den riskjusterade avkastningen.Resultat: Av resultatet framkommer att det går att utnyttja en investeringsstrategi där investering görs i låga EV/EBITDA-multiplar.

In order to accomplish that a construction is correctly built, it is critical to obtain a well functioning control mechanism throughout the project. The way to enable this is not by having an independent inspector constantly at your side. Today it is praxis to use check lists and have people responsible of quality to make sure that these are followed. This is where discretionary inspections play their part. These among others are documents needed to com-plete the check list.

Rett syndrome is a congenital neurological syndrome, which in the classic phenotype only affects girls. The symptoms include lack of speech, stereotypic movements of hands, dyspraxia and mental retardation, and these symptoms lead to communicative impairments. The purpose of this study was to examine whether the intervention method Intensive Imitation affected interaction/communication and initiative in a girl with Rett syndrome. The design of the study was a Single Subject Experimental Design with a three-week long intervention period where the girl participated daily in 30- minute sessions of Intensive Imitation together with the test conductor. Interaction, communication and initiatives were observed and analyzed before (Baseline A), during and after (Baseline B) the intervention period.

Bakgrund: I Sverige föds cirka 800 barn med hjärtfel varje år. Framstegen inom barnkardiologi och kirurgi har resulterat i att fler uppnår vuxen ålder än tidigare. Detta medför en växande patientgrupp, så kallade grown- up congenital heart disease (GUCH) patienter. Att leva med hjärtfel kan påverka det dagliga livet, såväl fysiskt som psykiskt. Syfte: Studien syftade till att undersöka vuxna patienters upplevelser av att leva med GUCH.

Forskningen kring effektiva marknader a?r uppdelad; ena sidan pa?sta?r att marknaden a?r fullsta?ndigt effektiv och det inte ga?r att skapa na?gon form av o?veravkastning. Andra sidan ha?vdar tva?rtemot att endast historisk information reflekteras i dagens priser. Pa? kort sikt kan det finns en viss ineffektivitet och de flesta erka?nner att marknaden inneha?ller anomalierSyftet med denna studie a?r att underso?ka om det existerar systematiska fel betra?ffande informationsflo?den som pekar mot att den svenska aktiemarknaden inte a?r av semi-stark form eller stark form av effektivitetVi utga?r fra?n tre metodologiska sta?llningstaganden; utga?ngspunkt, forskningsansats samt kunskapssyn.

Bakgrund: Medfödda hjärtfel tillhör de vanligaste missbildningarna hos levande födda barn. De stora framstegen inom hjärtkirurgin har lett till att fler barn överlever. Att få ett barn med medfött hjärtfel är väl dokumenterat som en mycket stressig upplevelse familjen. Föräldrar till hjärtsjuka barn uppvisar ett sämre välbefinnande jämfört med föräldrar till friska barn.Syfte: Att beskriva föräldrars upplevelser av att leva med ett barn med medfött hjärtfel.Metod: Allmän litteraturstudie med kvalitativ deskriptiv design och en deduktiv ansats. Katie Erikssons vårdteori om lidandet användes som teoretisk referensram.Resultat: Föräldrarna led av oro och stress i hög utsträckning och barnets hjärtsjukdom hadeen stor inverkan på hela familjens tillvaro.

The study emanates from the national quality registry for persons with severe and profound hearing impairment. The aim was to examine possible differences between signing deaf and adults with acquired severe hearing loss, with reference to self-assessed problems, how the hearing loss influences daily life.In total 234 adults aged 30-90 years were included (128 women, 106 men). In the registry, there are background variables and questions that the patients have answered. The results, indicated on a visual analogue scale (VAS) from 0-100, from a question ?To which extent does your hearing loss at present influence your life?? were analysed.The study was performed by pooling the results of VAS and dividing the patients into signing deaf and those with acquired severe hearing loss, and in age groups 30-60 and 61-90 years.

The intention of this essay is to study the Swedish General Staff as a learning organisation during the period of 1914-1918 based on the theoretical work developed by the philosopher Bertil Rolf. Previous international research on the Prussian/German General Staff has shown that it is considered to be the first learning organisation in history. The Swedish General Staff was based on the German General Staff model and the focus of this study is to compare the development the tactics in Germany and Sweden regarding defence and attack in trench warfare. The questions are: How were the possibilities for gathering and analysing informa-tion affected by the war? Which conclusions were made for trench warfare in Swedish conditions? What experiences from the war and exercises in Swedish army were implemented in manuals and training?The conclusion of the study is that the Swedish General Staff was functioning as a learning organisation during the WWI through the ability to follow the international development, mainly in the Central Powers, and by modifying the experiences to the prevailing Swedish strategic and tactical conditions.

Bakgrund: Varje år föds 1 % av alla barn i Sverige med medfött hjärtfel. Barnet med denna diagnos och dess föräldrar är i stort behov av omvårdnad. Viktiga komponenter i denna omvårdnad är stöd och uppmuntran, information på rätt nivå för mottagaren och att frågor blir besvarade. Föräldrar till barn med medfött hjärtfel lider i större mån än andra föräldrar av någon form av psykosocial stress eller ångest relaterat till barnets diagnos. Syfte: Syftet var att beskriva föräldrars upplevelser av att ha barn med medfödda hjärtfel.