Alternativ splicing är en process som ger upphov till att olika mRNA-sekvenser bildas från en enda gen, vilket bidrar till en ökad proteindiversitet hos organismen. Olika mRNA-sekvenser kan uppstå eftersom att det förekommer olika varianter av alternativ splicing som även kan kombineras på flera olika sätt: cassette exon (inkludering/exkludering av exon), intron retention (intronet behålls), alternative 5´splice-site choice (olika 5´ splice sites kan väljas) och slutligen alternative 3´ splice-site choice (andra 3´ splice sites kan väljas). För att alternativ splicing ska äga rum i olika pre-mRNA måste den regleras av cis-reglerande element. De cis-reglerande elementen utgörs av fyra grupper: exonic splicing enhancers (ESE), exonic splicing silencers (ESS), intronic splicing enhancers (ISE) samt intronic splicing silencers (ISS). Som namnen förtäljer finns de antingen i exoner eller introner, där de interagerar med transagerande faktorer, SR-proteiner (aktiverare) eller hnRNPs (hämmare).

In speech and language intervention, the ability to interact is seldom evaluated; rather intervention is evaluated in terms of improved testresults.  If goal-setting in intervention also is based on everyday communicative needs, the relevance of the treatment may be increased and intervention outcome may be implemented in the patient?s natural environment.The present study, as part of a research-project, is based on analyses of interaction and interviews to examine everyday conversations and speech and language intervention. The aim was to explore if there is a relation between everyday communication needs and goal-setting in speech and language intervention for people with aphasia. A further aim was to investigate if there are everyday communicative needs that may form goals for speech and language intervention.Two individuals with aphasia and one individual with both dysarhtria and aphasia participated in the study. Three speech and language pathologists and two relatives also participated in the study.

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

Since the breakdown of the Soviet Union, more than fifteen revolutionary yearshave passed. Estonia and Latvia have undergone a change from communist statesto members of the European Union. As in so many other post-communist statescorruption has been a problem. However, Estonia has since the independence hada lower degree of corruption than the neighbour country Latvia. The main purposeof this thesis is to explain why so.

The aim of this masters thesis is to, from a queertheoretical point of view, examine the possibilities to classify the subject homosexuality in three different classification systems. The three systems that have been analysed is the Swedish classification system SAB, the Universal Decimal Classification UDC and Dewey Decimal Classification DDC. The analysed editions are updates from the beginning of the 1970´s until today. The emphasis has been on how well the systems correspond to the changing society. We found several differences between the three systems, but also some resemblances.

Different forms of relaxing methods can be used in rehabilitation for individuals with tinnitus and Ménièré?s disease. Research continues to find convincing proof of effects from the different methods. This study presents methods of relaxing, massage and Mindfulness, as possible complementary rehabilitation tools.The purpose of this study was to investigate opinions about relaxing from professionals working with hearing care. A qualitative approach with phenomenological influence was chosen for the study.

This study, entitled A constant balance ? Gender equality work in an organisation dominated by women and an organisation dominated by men focuses on attitudes towards gender equality issues in two organisations ? one that is dominated by women and one that is dominated by men. The study is based on the Doing gender theory, which primarily means that gender is something people do, it is constantly changing and it depends on the surrounding context.The organisations in the study are both working with gender equality issues, but the attitudes towards gender equality work are ambiguous. The primary gender equality issue in both organisations is to increase the number of employees of the non-dominant gender. The gender equality work in both organisations is formally supported but it is also being met with informal resistance.

The aim with this project was to investigate how research grants in Sweden are distributed inthe selected fields; natural science, medicine and life science. Our client Olink producesdetection kits for biomarkers and our goal with this study was to give an indication of apossible new market area for their products. Three foundations were included in the study;VINNOVA, Vetenskapsrådet (Swedish Research Council) and Stiftelsen för strategiskforskning (Swedish foundation for strategic research). Nearly a thousand research grantswere analysed which included a total of 4,92 billion Swedish kronor. Seven selecteduniversities were contacted; Chalmers tekniska högskola, Karolinska Institutet, Kungligatekniska högskolan, Linköpings universitet, Lunds universitetet, Sverigeslantbruksuniversitet, Uppsala universitet.

Adolescence is more and more characterized by messages containing allusions and attitudes through social agents (family, friends, school and media). Therefore the purpose of this study was to investigate what significance the social agents and their messages, concerning sexuality, have in relation to young people's thoughts, questions and socialisation.The study is made from the young people's perspective. Our target group was 15 to 16-year-olds in ninth grade at a compulsory school in Sweden. The quantitative part of the study consisted of an anonymous and voluntary questionnaire among the students. To achieve a greater variety we made an interview as a complementary addition in which nine students participated.We found our main theoretical starting point in Anthony Giddens's theories about social agents, modernity, post modernity and sexuality.The conclusion was that the young people in our study foremost associated sexuality to sex, love, relationships and sexual orientation.

In this thesis the survival and development of a yearly recurring event will be examined. The purpose of this work is to examine how the festival Stockholm Pride has developed and to find out what underlying factors and conditions that lays behind the development. Also being examined is how the event affects Stockholm city?s tourism industry. To be able to fulfill the purpose of the thesis a qualitative research has been used and two persons with allot of knowledge about Stockholm Pride and Stockholm?s tourism industry has been interviewed.

Plesiomonas shigelloides is a gram-negative, oxidase-positive rodshaped bacterium of the family Enterobacteriaceae. P. shigelloides is most frequently isolated in tropical and subtropical areas, but has also been isolated in colder areas for instance in Sweden. The primary natural habitat of the bacterium is fresh water and indirectly waterliving animals, but the bacterium can also be recovered from humans, mammals (of which cats are over-represented), birds, insects and poikilothermic animals. P.

The purpose of this study was to examine young persons' experiences of life with ADHD. Semi structured interviews were done with four boys age 14-18 years, diagnosed with ADHD. The interviews followed a guide that consisted of themes with questions. The themes examined were: diagnosis, school, home, social and personal issues and how these themes are connected to ADHD. The results indicate that it is hard to live with ADHD.

Läkemedelshanteringen är ett av sjuksköterskans ansvarsområden inom hälso- och sjukvården. Utifrån kunskap och lagar skall den bedrivas på ett patientsäkert sätt men trots det sker läkemedelshanteringsfel vilket innebär risker i patientsäkerheten.Syftet med studien var att beskriva faktorer som påverkar säkerheten i samband med sjuksköterskans läkemedelshantering. Studien genomfördes som en litteraturstudie. Resultatet visade att vanliga läkemedelshanteringsfel är utebliven dos, fel administreringstid, fel dos, fel administreringssätt, fel läkemedel och läkemedel till fel patient. Faktorer som påverkar sjuksköterskans läkemedelshantering är felaktiga och dåligt skrivna läkemedelsordinationer, distraktion under läkemedelshanteringen, bristande rutiner samt införande av ny teknologi.

Live exports of animals began during the late 19th century and are nowadays a valuable alternative to the slaughter industry in Australia. About four million sheep and half a million to one million cattle are exported annually from Australia to the Middle East and Southeast Asia. Most of these animals are exported for slaughter, but some cattle are exported with the purpose of breeding. One factor that has been the driving force for the live export industry is that countries through tariffs and other barriers have favored the import of live animals rather than the import of meat.The export means that animals with a great cognitive ability are exposed to a long chain of production from the farm to the market and there are many factors that can affect the welfare of the animals in a negative way. Some of the most serious are high temperatures and a high stocking density, although seasickness, noises and handling can also have a negative impact on the welfare of animals.

Effektiviteten av manualiserad Motivational Interviewing prövades i en experimentell design. Gymnasieelever med hög frånvaro (n=89) blockrandomiserades till antingen två sessioner Motivational Interviewing eller någon av de två kontrollgrupperna, som erhöll validerande samtal respektive ingen intervention. Den beroende variabeln utgjordes av förändring i frånvaro som rapporterades av de deltagande skolorna. Utöver detta användes School Refusal Assessment Scale för att undersöka orsaker till frånvaron. University of Rhode Island Change Assessment användes för att mäta motivation enligt Prochaska och DiClementes förändringsmodell.