Methadone is frequently used as an analgesic drug for dogs although there are very few studies describing the pharmacokinetics of methadone in this species. In man methadone has a long half-life and there are considerable differences in pharmacokinetics between individuals. The dose interval is lengthened when the drug is used fore longer periods of time due to prolonged half-life. Therefore the drug dose must be adjusted individually. The purpose of this study was to study the fundamental pharmacokinetics of methadone in dogs, and to find an optimal drug dosage.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Artificial sweeteners in beverage and their effecton hunger and energy intakeAuthor: Sofia Andersson and Sofia JakobssonSupervisor: Heléne Bertéus ForslundExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 11, 2012BackgroundIn 2010 the total consumption of soft drinks in Sweden was estimated to 69 litres per person and17 % of the domestic production was estimated to consist of soft drinks sweetened with artificialsweeteners. The effects of artificial sweeteners on hunger is not yet fully understood. It isspeculated that they might increase hunger and hence increase energy intake.ObjectiveThe aim was to compile the evidence regarding the effects of an intake of a beverage sweetenedwith artificial sweeteners compared to sucrose on subsequent hunger and energy intake.Search strategyA systematic search for literature was performed in the databases PubMed and Scopus.Selection criteriaThe inclusion criteria were RCT, human studies, articles published in Swedish or English, studieson healthy adults and studies measuring hunger with a subjective scale or energy intake. Theexclusion criteria were studies who measured energy intake under other forms than standardisedor controlled, studies without a standardised dose of the beverage and articles needed to beordered against payment.Data collection and analysisFour articles were selected and examined according to a template developed by SBU. Theevidence for each outcome was weighed together and graded according to GRADE based on asummarised evidence form developed by the Sahlgrenska Academy.Main resultsAll four articles measured subjectively rated hunger.

Sahlgrenska Academy at University of GothenburgDepartment of Clinical NutritionAbstractTitle: The effect of nutritional treatment on functional recovery after stroke, a systematic reviewAuthor: Ingrid Blankenau and Amanda LindbladSupervisor: AnneMarie GrönbergExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTS Type of paper: Examination paper, 15 hpDate: April 13, 2011Background: Every year 30 000 people in Sweden suffer from stroke. This costs society about twelve billion SEK. Many stroke survivors experience functional impairment which may lead to difficulties for them to meet their nutritional needs. Nutritional treatment is important in the recovery process after stroke as malnutrition increases the risk of complications.Objective: To investigate the possible effect of nutritional treatment on functional recovery after stroke.Search strategy: The search was conducted in the databases PubMed, Scopus and Cochrane by using the English keywords stroke, nutrition, rehabilitation, functional outcome, recovery, acute stroke, ischemic stroke, ischemic acute stroke, nutrition therapy, brain hemorrhage, functional recovery and nutritional rehabilitation.Selection criteria: Studies published before 2001 conducted on human subjects who suffer from stroke where they measured functional capacity and did a nutritional intervention, written in English, Swedish or Norwegian, and did not have to be requested from the library.Data collection and analysis: A systematic search was performed in PubMed. Studies which had an interesting heading were examined and abstract read.

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Does the number of chews affect satiation and satiety?Author: Madeleine Johansson och Helena AnderssonSupervisor: Heléne Bertéus ForslundExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 27, 2014Background: Overweight and obesity is a growing problem worldwide. In 2008, 35% of theworld's population were overweight and 11% obese , which is almost doubling since 1980,according to WHO. Recommendations on overweight and obesity is not just about what weeat but how we eat. A generally accepted recommendation is to eat slowly and chew yourfood properly in order to increase fullness and reduce energy intake.

Successful broiler production in hot climates requires knowledge of how birds are affected by heat stress. It is important with access to water and good ventilation to facilitate coping with the heat. It may be useful to reduce the consumption of feed during the hottest hours of the days, which together with a few hours of extra light available could improve both productivity and animal welfare. The vision in birds is superior to that of humans and most other mammals. Continuous light and light with low intensity can cause eye injuries, affect the eye development in young chicken negatively, as well as provide increased incidence of foot pad lesions. Access to light affects the production but also the welfare of birds.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Coconut water and recovery/water-electrolyte balance after physicalexcercise ? A systematic overviewAuthor: Irene Eriksson and Alexandra ÖquistSupervisor: Henriette PhilipsonExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 09, 2014Background: During physical exercise, it is common with dehydration, which affectsperformance negatively. To restore the fluid balance it is optimal to drink fluids containingsalt and carbohydrates. In theory, coconut water should be a good recovery drink because oftheir nutrient content.Objective: To evaluate the scientific evidence available, to investigate whether coconut wateris better than water or sports drinks for rehydration after physical exercise.Search strategy: PubMed, Scopus and Cochrane Library have been used in the literarysearch. Keywords used were recovery, fluid balance, fluid therapy, water-electrolyte balance,rehydration, dehydration, hydration, exercise, physical activity, resistance training, activity,sports, training, coconut water in varying combinations, in order to cover as wide area aspossible.

Aim Developmental Coordination Disorder Questionnaire 2007 (DCDQ'07) is an international survey tool based on parents' estimation of their child's motor coordination skills. The purpose of this study was to investigate the validity of a Swedish version of DCDQ'07 by finding out how the classification of Developmental Coordination Disorder (DCD) via DCDQ'07 is consistent with the classification of DCD via the motor impairment test, Movement ABC.MethodIn the context of a larger study, a Swedish translated version of the parent survey DCDQ'07 were sent to 4000 randomly selected families with children aged 8 - 10 years in Stockholm County. The classifications "DCD" or "NOT DCD" with cut-off values ??of 56 (9 years) and 57 (10 years) were applied. Forty families were selected from 410 registered responses.

Sahlgrenska Academy at University of GothenburgDepartment of Department of Internal Medicine and Clinical NutritionAbstractTitle: Does coffee consumption affect the risk of stroke?Author: Jenny KällSupervisor: Heléne Bertéus ForslundExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22, 2012___________________________________________________________________________Background: The widespread consumption of coffee worldwide makes this drink interesting to study from a public health perspective. Even minor health effects may be important for the whole population. Stroke patients require the largest number of days spent in hospitals and nursing homes than any other medical condition group. Risk factors for stroke include smoking, high alcohol intake, physical inactivity, hypertension, hypercholesterolemia, high waist-hip ratio and diabetes.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Does low fat dairy products reduce blood pressure?Author: Emma Bergman and Naman LimaniSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 26, 2014Background: It is estimated that at least a third of the population in Sweden have a high blood pressure with genetics, unhealthy diet and physical inactivity as the main contributing causes. High blood pressure is one of the greatest risk factors to develop cardiovascular diseases, which is the leading cause of death worldwide. Milk is a nutritional food product and previous research suggests that low fat dairy products may have blood pressure lowering effect.Objective: The aim was to examine the scientific basis of how low fat dairy products affect blood pressure.Search strategy: Twelve searches were conducted on PubMed and Scopus, where the chosen search terms were combined to produce a broad search as possible in the particular area. The search terms used were dairy, dairy products, milk, blood pressure and hypertension.Selection criteria: Studies on normotensive or hypertensive individuals who received low fat dairy products were included.

In Sweden in January 2005, there is only one producer of organic broilers and none of organic turkeys. But there are, on the other hand, a few small-scale producers whose housing systems to some extent are similar to what is stipulated in the organic standards. The aims of this work are to investigate what housing systems are used by the Swedish small-scale producers of broilers and turkeys, what main challenges they are confronted with and if there is an interest and a possibility for a change-over to organic production. For the first part of this work a literature study was performed with the purpose of detecting the main health problems in conventional as well as smallscale production. A special focus was on coccidiosis and leg weakness as those were considered to be of particular importance. A study was made of Swedish small-scale poultry production units. In two groups of broilers from the same producer and in three flocks of turkeys the level of Eimeria oocysts in faeces and litter was investigated.

Sahlgrenska AcademyAt University of GothenburgDepartment of internal medicine and clinical nutritionAbstractTitle: D for depression: Does vitamin D supplementation have apalliative effect on depressive symptoms? ? A systematic reviewAuthor: Emelie Nacksten and Lua Ferreira RangelSupervisor: Fredrik BertzExaminer: Ingrid LarssonProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22th, 2013BackgroundDepression is one of the major diseases in the world and is ranked by the WHO as the leading causeof disability. Several studies suggest that there is a correlation between low s-25(OH)D levels and theoccurrence of depression. Current research has found enzymes required for synthesis of the active formof vitamin D and its receptors (VDR) in the brain. The potential role of the vitaminas a neuroactive steroid has resulted in an increased interest in investigating the role of vitamin D in thetreatment of depression.ObjectiveStudy the scientific evidence to determine if vitamin D supplementation can relieve depressive symptomsin adults.Search strategyThe literature search was conducted in the databases Scopus, Pubmed, Cochrane and PsychInfo.

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Coconut water as a rehydration fluid. - Can coconut water be recommended as a better choice than water or sports drink after moderately intense training?Author: My Green, Joakim LundSupervisor: Henriette PhilipsonExaminer: Frode SlindeProgram: Dietician study program, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 26th, 2014Background: Already in the 1960s an alternative to water as a rehydration fluid occurred, the so-called sports drink. Coconut water has in recent years been claimed as the "natural sports drink" in media. Coconut water is sold in shops and fitness centers around the world and has established itself as an alternative to water and sports drink in terms of rehydration after a workout.Objective: To investigate whether there is scientific evidence to recommend coconut water as a rehydration drink after moderately intense exercise ahead of water or sports drink.Search strategy: The search for articles in this systematic review was performed in the databases PubMed, Scopus, Cochrane and GUPEA.

AbstractTitle: Does supplementation with omega 3 improve oxygen uptake among athletes?Author: Jonna Gustafsson and Maria Bohlin Nygren Supervisor: Frode Slinde Examiner: Ingrid Larsson Programme: Programme in dietetics, 180/240 hp Type of paper: Bachelor?s thesis in clinical nutrition, 15 hp Date: May 26, 2015Background: Previous research has shown that omega 3 fatty acids may improve cardiovascular functions by decreased aggregation and increased red blood cell deformability. This produces an increased blood flow and could have a potential effect on oxygen uptake. Optimal aerobic capacity is a determinant factor of performance within endurance exercise.Objective: To compile scientific research of the possibility that omega 3 supplementation could improve oxygen uptake among athletes.Search strategy: The literature research is based on searches in PubMed and Scopus with the terms ?Physical Endurance?, ?Oxygen Consumption?, ?Fatty Acids Omega 3?, ?Dietary Supplements?, ?Exercise?, ?Fatty Acids Essential?, ?Docosahexaenoic Acids?, ?Eicosanoic Acids?, ?Fish Oils?, ?oxygen consumption?, ?maximal oxygen consumption?, ?VO2 max?, ?athlete?, ?omega-3 supplementation?, ?physical endurance?, ??-3?, ?omega-3?, ?Maximal Aerobic Power?, ?Oxygen Uptake?, ?VO2? and ?Maximal Aerobic Capacity?.Selection criteria: Randomized controlled trials (RCT) with an intervention of omega 3-supplementation during three weeks or more were included.

Various problems with nail disorders have been noticed in the Swedish population of Giant Schnauzer, but the frequencies of these problems are unknown. This could be due to the fact that bad nail quality has several differential diagnoses and lack of diagnostic criteria and diagnostic codes for nail disorders. The main purpose of this study is to review different types of claw defects and diseases of the nail bed in dogs, and to classify and evaluate the proportions in the Swedish Giant Schnauzer population. The nail is a specialized part of the skin. The quick will strengthen and protect the third phalang against the surrounding.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Alcohol consumption after training and its effects on muscle gain and recovery adult menAuthor: Frida Carlstedt, Puck JanssonSupervisor: Frode SlindeExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 09, 2014Background: Today, the Swedish population exceeds the recommendations for alcohol intake while advised to move at least thirty minutes a day. It is well established what happens if you drink alcohol before a workout or if you workout the day after an alcohol intake, but it is less well established how muscle gain and recovery are affected by an intake of alcohol in the phase of recovery.Objective: The objective of this review is to investigate if there is a relation between alcohol intake after a workout and effected recovery and muscle gain. This was performed by measuring the outcomes cortisol, testosterone, creatine kinase as well as different measures of muscle strength. The issue was ?Does an intake of alcohol after training affect recovery and muscle gain??Search strategy: A systematic review in the databases PubMed and Scopus with the MeSH-terms: exercise, muscles, recovery of function, training, athletic performance, performance, sport, alcohol drinking, alcohols, alcohol and ethanol.Selection criteria: Criteria for articles to be included in this review were that they would be RCT- and human studies in healthy subjects as well as containing an ethanol intake after a physical activity that consisted of weight training in the form of resistance training or other forms of activity that promotes strength.Data collection and analysis: A systematic search for literature as mentioned above (search strategy) was performed as well as an analysis with the SBU quality review template for randomized studies, and a quality review for each measure of outcome according to Gothenburg University summarized evidence template for measures of outcome.4Main results: Many studies are authored by the same group of researchers and/or are of a lower quality.