Rheumatoid arthritis is an autoimmune disease, where joints are attacked by the own immune system, leading to chronic inflammation and destruction of bone and cartilage. Inflammation is a complex process, controlled by many different substances. One of them is adenosine, which has anti-inflammatory properties. In this project, three polymorphisms in different genes, involved in synthesis and signaling of adenosine, were genotyped for 188 patients with RA and 362 controls without RA. The results shows that for the polymorphism in A2a, a gene coding for an adenosine receptor, there was no significant difference in genotype distribution between the groups.

Erythropoiesis is a complex and carefully controlled process which is mainly regulated by erythropoietin. Using flow cytometry cells in a blood sample can be analyzed one by one. ADVIA 2120 using flow cytometry for analysis of red blood cells (RBC) and reticulocytes. Red blood cell distribution width (RDW) is a component of the RBC method. RDW indicates size variation on erythrocytes and is measured as a percentage of the mean cell volume (MCV). By measuring the RDW anemia can be divided into makrocytic, microcytic or normocytic. Reticulocytes refract light more strongly than red blood cells because they contain some cellular debris. The number of reticulocytes in the peripheral blood reflects erythropoiesis in the bone marrow. The purpose of this project was that by approved methods to establish reference ranges for the parameters, RDW and reticulocyte counts.The individuals who participated in the study, n=124, were considered healthy and had varying ethnicity. Reference subjects had not donated blood the last six months and participation in the study was voluntary.The statistic evaluation includes examination of distribution, and reference ranges for both men and women were established using the 2.5:t and 97.5:t percentiles. The calculated reference interval for RDW was between 12.0 ? 14.3% and the calculated reference interval for reticulocytes was between 38.0 ? 112.8 x109 cells/L. The results showed a significant difference between males and females for the parameter reticulocytes was seen. The difference indicates that different reference ranges should be established for men and women (p<0,0001). No significant difference between males and females were seen for RDW (p=0,74) indicating that the same reference ranges can be used for both men and women. .

To become a successful athlete requires several different components in which one of themost significant is the ability to develop their own physical strenght. What weight exercises has the best transfer effects for skating?Participants in the study were 20 male senior hockey players from Div. II in the Västra Gö- talands Regionen in which all participants had at least 10 years of hockey experience.Test subjects had to perform a five-minute individual warm up followed by an opportunity to familiarize with the upcoming exercise. The first on-ice test was a 35 meters sprint test and the second test was an S-cornering agility test.

The purpose of this study was to investigate different relations between the damages of falls and background variables as well as the relation between the falls and the weather condition to later be able to use this report to expand the knowledge among workers at VTI about the pedestrian fall injuries. All of the fall injuries in the data that this study is based on have occurred in Sweden during the time period between January 2003 and December 2011.To be able to answer the questions that this report is based on several statistical methods are used. The statistical methods that have been used during the making of this report are multiple linear regression, binary logistic regression, correlation analysis, association analysis and descriptive statistics as well as visual analysis.The results of the study show that women around menopause age have a tendency to get a big increase in the amount of injuries compared to men of the same age. The study also suggests that men on average tend to have a lower level of injury compared to women.Age also seems to affect both the amount of injuries and the level of injury negatively. The study suggests that the most likely reason for this is both that the intake of ?Fall Risk Increasing Medicine?, which is medicine that increases the drowsiness, is higher among older individuals as well as lower estrogen levels among older women and lower amount of testosterone among older men, which causes a loss of bone density in both sexes.The weather seems to have a strong effect on how many injuries occur but also a noticeable effect on the scale of the injury.

Osteoporos är en sjukdom som under de senaste decennierna ökat. I Sverige inträffar det cirka 70 000 osteoporosrelaterade benbrott varje år. Den största gruppen som drabbas är kvinnor efter menopaus. Syftet var att belysa faktorer som är av betydelse för prevention av osteoporos och osteoporosrelaterade frakturer hos postmenopausala kvinnor. Metoden var en systematisk litteraturstudie bestående av 10 vetenskapliga artiklar varav 9 baserade på kvantitativ och en på kvalitativ forskning.

In metabolism Mg plays an important role because it affects many cellular enzymes in the body. The energy metabolism and protein synthesis are dependent on Mg as an enzyme activator, Mg is also involved in the synthesis of RNA and DNA. Absorption of Mg primarily takes place over the ruminal epithelium in ruminants. The main storage of Mg is in the bones but that can only be reached if the cow is in great need of calcium or phosphorus, it's a hormonal regulated process that induces catabolism of bones. Free and available sources of Mg are found in soft tissues and in the extra cellular fluids that includes cerebrospinal fluids and blood.

This is an empirical cross-sectional study with the aim to examine the patient?s comprehension about their quality of life within two to seven years after their stem-cell transplantation with reference to physical, social, emotional, psychological and functional wellbeing and to investigate if the patient groups have disease specific problems. Differences in quality of life between men and women and also between allogeneic and stem cell transplantation with an unrelated donor (URD) were studied. The measurement Functional Assessment of Cancer Therapy (FACT) and the bone marrow transplant subscale (BMT) is a 49 item, valid and reliable measure that was used. The questionnaire was answered by 43 of 47 patients (91%).There is a significant difference between men and women in physical, social and functional wellbeing.

The Center for Genomics and Bioinformatics (CGB) is an academic department at Karolinska Institute. Generally stated, the CGB department is committed to the generation and management of genetic information by approaches aiming at elucidating the connection between genes, protein and function.WiGID is a genome information database that is available through WAP (Wireless Application Protocol).Our version of WiGID is based on WML, PHP and PostgreSQL as a database server.One of the changes on the old WiGID application was the creation of a relational database with seven tables and one view, instead of the file that represented the database on the old version. We also changed the script language from python to PHP.The search engine ability has been extended with three new search alternatives for a user to choose from. Each choice leads to other, sometimes multiple choices.A GUI has been created for the administrator, to be able to insert information into the database.The structure of the search engine is primarily for narrowing down the search result on the phone display, thereby making the search efficient..

Weaning is one of the most critical events in the piglet production with problems such as growth check and post-weaning diarrhea as a result. The lighter the piglets are when the growth check occurs, the harder they have to get back to normal growth rate. Creep feeding of piglets is used to reduce the problems by increasing the weaning weight and adapting the digestive tract to a starter diet. Hodge (1974) showed that the sow?s milk can not provide enough nutrients for maximal growth rate.

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical NutritionTitle: ?What nutrition therapy has the best outcome on growth in preterm children and/or children born with low birth weight??Author: Josefine Nyström and Rebecca HammarSupervisor: Fredrik BertzExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 11, 2013Background: There is a number of reasons why a child is born preterm and with a low birth weight, for instance if the mother is underweight, smoking or exposed for malaria. The negative consequences of being born preterm or with a low birth weigth are many, both on long and short term. According to the WHO preterm birth is the most common direct cause of infant mortality. By providing the right measures in time when it comes to nutrition the mortality can be reduced considerably.Objective: To examine and summarise the scientific ground when it comes to the best nutrition therapy for preterm children and children born with a low birth weight.Search strategy: A systematic literature search was done in the databases Pubmed, Cohrane and Scopus.

Mastitis, inflammation in the udder tissue, caused by S. aureus is a big problem in dairy cattle production. It causes suffering for the cow and curing or replacing the infected cow is costly for the farmer. It is known that beef cattle also suffer from mastitis caused by S. aureus.

This review article presents the splicing process during messenger RNA maturation and how it is regulated by different Cis-regulatory RNA-sequence elements and splicing factors. A more detailed description of the process alternative splicing and its importance to the function of genes from the model organism Arabidopsis thaliana is also given. A single eukaryotic gene can by the process alternative splicing (AS) give rise to a number of functionally mature mRNA-molecules, which in turn encodes for structurally and/or functionally different proteins. During the course of evolution, the process alternative splicing has thus shown to be effective in increasing transcriptome and proteome diversity of most eukaryotic organisms. This suggests therefore that the dominant theory in molecular biology, a gene encodes for a protein, needs to be corrected.

Enligt den svenska skollagen (SFS 2010:800) har elever i skolan rätt till näringsriktiga skolmåltider. I lagtexten saknas förklaring om vad den näringsriktiga måltiden innebär, men regeringen hänvisar till de svenska näringsrekommendationerna som utgångspunkt. Syftet med denna rapport var att undersöka skolors tillvägagångssätt för att servera en näringsriktig måltid i skolan. Den kvalitativa intervjun användes som metod för att under-söka detta i fem skolor belägna i Uppsala kommun. Livsmedelsverket har skapat en vägledning, ?Bra mat i skolan?, som ger rekommendat-ioner för skolmaten baserat på de svenska och nordiska näringsrekommendationerna.

The study was carried out at the Kungsängen Research Centre, Department of Animal Nutrition and Management, Swedish University of Agriculture Sciences, Uppsala. The technical development in dairy production has resulted in a housing system where feeding and milking is done automatically without human contact, a so called automatic milking system. The motives for utilising an automatic milking system, is to increase the animal welfare and to decrease the need for manual labour. However, the system does involve a change for the animals, among the effects is the deprival or the diminishment of a chance for synchronous behaviour and the animals have to agree among themselves in which order they use the feeding stations and the milking unit itself. How and if this affects the animals well-being and production is yet to be solved. A possible way to form an opinion on this, is to study the animals ranking order along with hormone profiles and production. The purpose of this work was to study the effect of low- vs.

This study was performed in order to evaluate if the method of collecting uterine secretion by the tampon-method is representative for use in studies of uterine secretions in mares. Uterine secretion collected by tampon in six mares was compared with secretion collected by aspiration, regarded to be a native sample, at the Institution of Obstetrics and Gynaecology, SLU, Uppsala. Proteinanalysis was made at the Department of Farmaceutic Bioscience, toxicological unit, Uppsala University. Cytological smears and ultrasonography was used to assess if the tampon had caused an inflammatoric reaction that could influence the protein content of the samples. The results suggest that the tampon and aspirat method do not differ when it comes to proteinconcentration, but the distribution of proteins differ between these different collection methods. This difference could not likely be explained by means of proteins due to an inflammatory reaction from the tampon, since neither the cytological nor the ultrasonographical examination gave any indications of inflammation.