Background:  Heart failure is a multidimensional phenomenon with high mortality. Heart failure is treated with angiotensin converting enzyme (ACE) - inhibitors or angiotensin receptor blockers (ARBs) that counteract neurohormonal stimuli that occur in heart failure, as well as providing vessel dilatation, which reduces symptoms and the need for hospitalization and increases survival. Despite this, only about 50% of heart failure patients survive 6 years after diagnosis with drug therapy, and as heart failure is increasing globally, due to improved care and treatment and increasing life expectancy of the population, there is a great need for new drugs such as LCZ696 that acts by dual inhibition of the renin - angiotensin - aldosterone system and neprilysin inhibition.Objective: The aim of this literature study was to evaluate the efficacy of current treatment and possible future treatments on mortality and morbidity in heart failure patients.Results: The examined articles show that treatment with ACE inhibitors in patients with symptomatic heart failure reduces the risk of total mortality by 16% over 3.5 years, reduces all-cause mortality or hospitalization due to heart failure with NNT (number needed to treat) = 10.4 over 3.5 years and increases median survival by 9.2 months over 12.1 years in patients with asymptomatic heart failure. Treatments with high-dose ACE inhibitors reduce mortality and hospitalization because of cardiovascular causes and hospitalizations from any cause by NNT = 30 over 3 years. Beta-blockers reduce sudden death and total mortality and cardiac death or non - fatal myocardial infarction with NNT = 38 and NNT = 23, respectively, over 12 months.

- To be trapped in a roller-coaster That ?s how some of the patients are describing the situa- tion of living with heart failure. To be stuck in their home not knowing if they will have to seek care today and not knowing if they will have the energy to attend that birth- day party later this week.Each year 2-3% of the Swedish population are diagnosed with heart failure, which results in 30,000 new individu- als with the disorder. Cardiovascular disease is rapidly in- creasing in the world and before 2030, people with heart failure will increased by 100%. Our improved living condi- tions and better health have allowed us to grow older and made us more dependent on other types of care, care at home.Today the patients are only looking for changes in weight and if they have excessive water in their body.

Bakgrund: Sjuksko?terskestudenter kommer i kontakt med palliativa och cancerpatienter flertalet ga?nger under sin kliniska utbildning. Detta pa?verkar studenterna olika ka?nsloma?ssigt. Fo?r att hantera dessa nya upplevelser tilldelas studenter en handledare som skall ge sto?d, undervisa och guida dem under den kliniska utbildningen.Syfte: Syftet med studien var att underso?ka sjuksko?terskestudenter uppfattning av mo?tet med palliativa patienter samt erha?llen handledning i samband med dessa mo?ten.Metod: Metoden till denna kvalitativa studie var tva? semistrukturerade fokusgruppsintervjuer med ett bekva?mlighetsurval av studenter som haft klinisk utbildning pa? hematolog, onkolog eller palliativ avdelning.Resultat:Va?rd av palliativa patienter eller patienter med cancer uppfattades som en sorglig, sva?r, obekva?m men la?rorik upplevelse.

Powdery mildew is a serious problem in both field and greenhouse cucumber production and can cause serious infection and radically reduced yields. Today, powdery mildew is the main disease in greenhouse produced cucumber. Disease control should preferably be both efficient and environmentally friendly, which is not easy to achieve at all times. Alternatives to chemical control of powdery mildews are biological control, physical control, non-fungicide control and cultivation of resistant or tolerant varieties. Biological control can be described as the suppression of damaging activities inflicted of a harmful organism by one or more other organisms, which are called antagonists or natural enemies. In Sweden, there are currently no registered biological control products available to control cucumber powdery mildew. The aim of this study was to investigate the effect of two biological control products in order to evaluate their ability to prevent or reduce powdery mildew infection to an acceptable level in greenhouse produced cucumber. In the experiments, different application regimes were also studied.

AimThe purpose of this study was to examine the relationship between physical strain and recovery in dancers at The Ballet Academy in Stockholm, Sweden. Research questions used to guide the study were: How great is the dancers experience of physical strain? Do any of the dancers show mental or physical signs of overtraining syndrome?MethodPhysical strain was studied by letting the dancers fill out a booklet catloging their intensity during practice. Utilizing a questionnaire, data was gathered regarding preceding year. To give more nuance to the data gathered, The Profile of Mood States was used to detect possible mood disturbance.

Canine dilated cardiomyopathy (DCM) is a disease with high morbidity and mortality and with a high prevalence in certain breeds. Predominatly large breeds are affected, such as Great danes, Newfoundlands, Deerhounds and Dobermanns. One exception is Cocker spaniels, where both American and English Cocker spaniels are affected in a quite high frequency. Cardiomyopathy is characterised as a disease that affects the myocardium and gives an impaired heart function. To diagnose DCM following criteria have to be observed: 1. Dilation of the left ventricle. 2. Reduced systolic heart function. 3. Increased sphericity of the left ventricle. To be certain of the diagnosis, alternative reasons for the symptoms such as lung- and heart diseases with other etiologies have to be excluded Two different types of DCM have been found upon histological examination.

Bakgrund och problem: Dagens företag verkar i en osäker och dynamisk miljö där marknaden ställer allt högre krav på snabba förändringar och anpassningar till kundernas behov. För att möta denna dynamiska omgivning har en rad nya produktionsfilosofier introducerats. En av dessa som fått stor uppmärksamhet och vars användning ökat är lean.Under senare år har det kommit att riktas stark kritik mot tillämpningen av traditionell ekonomistyrning och att denna kan vara skadlig vid tillämpningen vid lean. Andra forskare tar det steget längre och ställer sig frågan om det finns någon plats för ekonomistyrningen vid operationella koncept.Som ett svar på ovanstående kritik introducerades lean accounting, ett ämne som fortfarande är hårt debatterat inom managementlitteraturen. Andra forskare skiljer här på lean accounting och lean control, där lean control fokuserar på output, behavioral samt social control.

Listeriosis, which is caused by Listeria monocytogenes, is a rare food borne disease that primarily affects people whose immune system is weakened. These may be elderly people, pregnant women, new-born infants and individuals on immunosuppressive medication. The most common symptoms are meningitis, septikemia and abortion. The mortality is high, on average 20-30 %. In recent years the number of cases in Sweden has increased.

Teorier inom relationsmarknadsföring har talat om hur företag kan vinna konkurrensfördelar genom att erbjuda kunden ett totalt serviceerbjudande, där kunden och dennes behov står i centrum. Teorierna beskriver vidare humankapital som den viktigaste resursen och talar i anslutning till detta om utbildning, befogenheter och god kommunikation med ledning. För en mindre aktör på detaljhandelsmarknaden krävs nya vägar att differentiera sig när större, väletablerade kedjor erbjuder likartade sortiment till liknande priser. Parfymeri L är ett familjeföretag med butiker i fem svenska städer som säljer selektiv kosmetik. De satsar på att erbjuda personlig service och uppger att personalen är den viktigaste resursen för ett företag i deras position.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

Bakgrund: Sjukdomen schizofreni innefattas av symtom såsom vanföreställningar, vrede och apati samt har en hög självmordsprevalens. Närstående får ofta en minskad livskvalitet pga. de stora påfrestningar de utsätts för. De behöver stöd från vården för att orka vara delaktiga i den sjukes liv. Syfte: Att beskriva upplevelser av att vara närstående till en person som har schizofreni och på så vis öka sjuksköterskans förståelse för denna individgrupp.

ForskningsfrågaÄr det möjligt att skapa riskjusterad överavkastning med hjälp av nyckeltal inom industribranschen på den Nordiska aktiemarknaden?SyfteGår det att generera en riskjusterad överavkastning genom att använda en investeringsstrategi baserad på något eller några av nyckeltalen P/S, P/E, P/B, EV/EBITDA samt med en egen modell innehållandes de tre förstnämnda nyckeltalen. Detta undersöker vi genom att samla in data och utföra statistiska tester där vi ställer portföljer med låga värden på nyckeltalen mot portföljer med höga värden på nyckeltalen.TeoriTeorin inom området är uppdelat i två läger, de som påstår att marknaden är effektiv som t.ex. Fama och de som påstår att marknaden är ineffektiv som t.ex. Haugen.

Syftet med studien var att undersöka priming med exempels påverkan på skapelsers kreativitet. Effekterna av priming skulle testas i formen av egenskapspriming såväl som konceptuell priming och mätas utifrån både en användbarhetsaspekt och en originalitetsaspekt. Ett delsyfte var också att undersöka sambandet mellan intresset för att ta fram en skapelse och en skapelses grad av originalitet samt användbarhet.Primingeffekterna prövades genom ett experiment där 36 studenter delades in i 3 grupper som fick i uppgift att ta fram IT-lösningar för kollektivtrafiken. 2 av grupperna primades med var sitt exempel på hög originalitet respektive hög användbarhet.Effekterna av egenskapspriming undersöktes sedan genom en jämförelse mellan grupperna över hur stor andel av de framtagna lösningarna som innehöll egenskaper från exemplen. För att undersöka effekterna av konceptuell primingen gjordes en jämförelse av originaliteten och användbarhet hos dessa gruppers lösningar jämfört med de framtagna av en kontrollgrupp utan tillgång till exempel.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.