Bakgrund: I dag har 220 miljoner människor diabetes världen över och 90 % av dessa har typ 2 diabetes. Sjukdomen föregås alltid av en insulinresistens och eftersom den har en koppling till oxidativ stress är en teori att spårämnet selen kan spela en viktig roll. Det är känt att selen har antioxidativa effekter i kroppen och tidigare djurstudier har visat att selen skulle kunna härma insulinets effekter samt öka insulinkänsligheten.Syfte: Att ta reda på om selen kan skydda mot utvecklingen av typ 2 diabetes. De frågeställningar som användes var om selensupplementering, selenintag via kosten eller selenstatus i blod kan påverka risken att utveckla typ 2 diabetes hos friska individer.Sökväg: Datainsamlingen genomfördes i den medicinska databasen PubMed med sökorden ?selenium AND diabetes mellitus type 2?.

The aim of this study was to detect antibodies in swine serum against proteins in soy beans, wheat, oat and barley. Two methods were used: agar gel immunodiffusion test (AGID), and SDS-PAGE followed by immunoblotting. The sera examined originated (I) from piglets younger than one week (negative control), (II) pigs from a feed trial with soy bean in a herd with PMWS, and (III) pigs inoculated with Brachyspira hyodysenteriae and Escherichia coli after being fed with soy. The AGID-test was negative concerning all examined sera which were analysed against proteins in soy bean, wheat, oat and barley. In the experiment based on immunoblot antibodies were demonstrated within all three groups of examined pigs.

Hyperthyroidism has become the most commonly diagnosed endocrine disorder in cats. The recommended treatment of choice in the literature is administration of radioactive iodine. This treatment has been available at a few veterinary clinics in Sweden since 1999. Forty-six cats treated with a standard dose (80 MBq) of radioactive iodine (131I) at the Swedish University of Agricultural Sciences in the period 2000-2004 were followed for a median of 13 months (range 3-42 months) by means of a retrospective cohort study design. Tables predicting time of survival after treatment were made. At final follow-up thirty-nine cats (85%) were euthyroid, six cats (13%) remained hyperthyroid and one cat (2%) was hypothyroid.

Among those who graduate from the various schools of Social work in Sweden are a great majority women. At the same time men are sought after in the work field.  But not just to level up the equality between the sexes, but also to fill a gender specific niche to counter up a need for male role models. But a closer look at this need and the types of functions set to cater for it shows that male role models as a concept vary between contexts. In this study we examine the concepts and the practices of male role models in three different settings: a municipal social care center offering young boys male bonding activities; a non-profit organization warding young people from drug abuse and criminal behavior; and last, a long term residential home for young boys between the ages 13 and 19. Our research shows that the concept of the male role model vary between the organizations and less so within.

PAPRO operates within the Forest Research company and their mission is to develop value-addingindustry solutions. At present there are no good ways for mills to easily test the printing quality on newsprintpaper. There is a great need for a fast way to do this on different paper qualities; with a laboratory-offset press this can be both a time and money saving method. At PAPRO Forest Research, NewZealand, a laboratory offset press has been developed and designed, during the past seven years, concerningthis issue. Earlier projects were made concerning the press, e.g.

Feline infectious peritonitis (FIP) is a feline viral disease with high mortality. There is no cure or any effective vaccine available today. Many questions are yet to be answered about this disease and the immune response in affected cats. The aim of the study is to evaluate two different techniques for the study of cytokine profiles in cats vaccinated with a vaccine concept against FIPV. More information about the immune response in these cats could give valuable information to better understand the pathogenesis of the disease and the development of an effective vaccine.

Laminitis is a debilitating disease causing much suffering to horses and ponies all over the world. It is manifested in the hooves as a mechanical failure of the suspensory apparatus between the hoof capsule and the distal phalanx. Due to the weight of the horse the disease may result in a dislocation of third phalanx. Six healthy standardbred trotters were used in this study on whether standardbreds tolerate forced recumbency as well as Shetland ponies. Recumbency was induced pharmacologically but maintained only by lowering the ceiling height of the box to a height of approximately 125 ? 140 % of the horse´s thoracic height.

The aim of this thesis is to analyze the academic discipline translation studies; the analysis centers upon bibliometric aspects, and is carried out chiefly by means of quantitative methods, enabled by the databases Web of Science and Scopus as well as by the corpus-linguistic software Wordsmith; however, this quantitative focus is complemented by auxiliary qualitative means of investigation, i.e. a discourse-analytically oriented study of a corpus of domain-endemic reviews.A number of core journals are analyzed in order to show what and whom are cited in translation studies, and, furthermore, what adjacent domains hold sway over it; attention is also given to influential authors, regions and languages operating within the domain. It is shown that the domain under scrutiny is quite differentiated, even fragmentary; the term pluricentric is used to describe this tendency towards sprawling. No superior authors (in terms of publication frequency) emerge, which arouses the suspicion that the domain may be conditioned by a hierarchical divide between journals and monographs. Furthermore, it is clear that translation studies is a eurocentric domain: European languages dominate.

Apart from recognizing and neutralizing threats, antibodies also have the ability to regulate immune responses against their specific antigen. IgG administered together with erythrocytes is well known to induce >99% suppression. This has been used to prevent haemolytic disease in new-borns since the 1960's, but the mechanism behind it is still not completely understood. The effect on the primary response is well established, but its influence on induction of immunological memory is still heavily debated. In this study adoptive cell transfer of splenocytes to irradiated mice was used to survey the effect IgG has on induction of immunological memory without disturbance from the primary IgG response.

Det saknas idag metoder för att med säkerhet fastställa diagnosen Bornasjuka intra vitum. För att få en så säker diagnos som möjligt krävs fortfarande histopatologiska belägg och påvisande av virus i material från centrala nervsystemet, vilket ej kan tas från levande djur. Trots det finns det en risk att det intracellulära viruset undgår detektion då infekterade celler ej är jämt fördelade i hjärnan. De kliniska symtomen är specifika enbart för infektion i centrala nervsystemet och inte för Bornasjuka. Att förlita sig på antikroppar är osäkert på grund av låg titer som kan göra testen mindre tillförlitliga.

I denna studie har förekomst av progesteronreceptorer i olika typer av primära juvertumörer undersökts med hjälp av immunohistokemi. Dessutom har tumörceller från carcinomcellinjen CMT-U27 odlats i olika cellodlingsmedium och exponerats för olika testsubstanser som binder till progesteronreceptorn (progesteron och RU486/mifepristone). Cellernas receptoruttryck och progesteroninnehåll utvärderades med hjälp av ELISA och tumörcellernas viabilitet analyserades med Colorimetric Cell Viability Test. Av resultaten framgår att samtliga undersökta primära juvertumörer uttryckte progesteronreceptorer. De odlade cellerna hade högre cellviabilitet när de odlades utan fetalt bovint serum (FBS). Efter exponering med progesteron minskade tumörcellernas uttryck av progesteronreceptorer, vilket hämmades av mifepristone.

The genus Borrelia is a widespread, pathogenic pest and the causative of among others borreliosis or Lyme disease. The vector for the bacteria is the hard tick, Ixodes ricinus and the infection is transferred through a bite. Untreated, Borrelia may cause arthritis, heart damage or neuroborreliosis. Infection is made possible through different strategies for avoiding the body?s complement system.

Bakgrund:Den dominerande cancerformen hos män över 75 år är prostatacancer. Kosten har en påverkan på många sjukdomstillstånd och på senare tid har man undersökt misstankarna kring om höga nivåer av IGF-1 kan öka risken för att utveckla prostatacancer. IGF-1 finns naturligt i kroppen men hormonet finns bland annat också i vissa livsmedel så som mejeriprodukter. Syfte:Att granska tillgänglig evidens gällande samband mellan höga nivåer av IGF-1 och prostatacancer, samt att om ett samband går att finna, undersöka om en kostrekommendation kan göras för att sänka nivåerna av detta hormon i kroppen och på så vis minska risken för utveckling av prostatacancer. Metod:Systematisk litteraturstudie.

African swine fever, ASF, was first described 1921, in Kenya. The virus has thereafter spread through many African countries as well as in Europe, Asia, South- and Central America. The virus is spread via three different cycles, of which one is sylvatic and includes warthogs and soft ticks. The other two are between domestic pigs and the one most common one is caused by humans, who not always realize the seriousness of precautions. The infection manifests as hemorrhagic fever, but can also be more or less unnoticed. The aim of this study was to use molecular tools to detect and partly genetically characterize ASFV both in soft ticks and in serum from domestic pigs in Uganda. Comparing viruses detected in ticks with those detected in domestic pigs I also wanted to investigate possible links between the sylvatic and domestic cycle.

Extensive cattle management was reintroduced in Sweden during the 1950´s and 60´s. Usually this term refers to suckler cows for meat production that is kept outdoors all year around. Suckler cow farms tend to become fewer but bigger over time. Still however most of the farms with beef cows are small. Extensive animal husbandry can lead to animals becoming shy which leads to difficulties when they are handled due to veterinary treatments, marking, transport etc.