Osteoartrit (OA) är ett mycket vanligt problem hos hästar och har i många fall sitt ursprung från felaktig belastning av leden, blir ofta kroniska och omfattar inflammation i ledens samtliga ingående delar. Resultatet är bland annat nedbrytning av ledbrosk och matrixkomponeneter. Idag baseras diagnostik och framtida prognos mestadels på den kliniska bilden och/eller bilddiagnostiska hjälpmedel. I denna studie har två inflammationsmediatorer; interleukin 1? (IL-1?), high mobility group box protein 1 (HMGB-1), och ett enzym; matrixmetallopeptidas 13 (MMP-13) mätts i ledvätska och serum med hjälp av kommersiell enzyme-linked immunosorbent assay (ELISA)-teknik. Hypotesen är att dessa är förhöjda i ledvätska från leder med konstaterad hälta. Tjugonio ledvätskeprov och 11 serumprov från 11 hästar som sökt till Universitetsdjursjukhuset i Uppsala för hälta analyserades i denna studie.

The academic underachievement of looked after children is well known. By involving foster carers in a Paired Reading intervention a Swedish project tried to address this issue, replicating a successful British trial. The aim of my thesis was to study the variations in the foster carers? experiences of this literacy intervention. Reading reports from 100 children were collected and qualitative interviews with 15 foster parents were analyzed using concepts from motivational psychology.

Today the milk production per cow is increasing but the milk delivered by the Swedish farmer contains less amounts of fat and protein than earlier. The contents have decreased since 1993. In average the milk contain 4,2 percent fat and 3,4 percent protein. Earlier the fat content in milk was important. Nowadays the dairy?s attention has turned to the milk?s valuable proteins, principally the caseins, which have a considerable nutritional value and are important for several dairy products like cheese and yoghurt.

The dog has often served as a model animal for humans in scientific studies. This is due to the fact that dogs are susceptible to a wide range of diseases which also affect humans. One example is cancer, a condition that affects dogs as well as owners. Neoplastic diseases account for 18-23 % of all deaths in dogs (Bonnet et al., 2005 and Jagielski et al., 2002). Mammary tumor, or tumor of the breast, is the most common tumor form in intact dogs and women (Im et al., 2013). Mammary tumors originate in the udder, and are classified according to their histological characteristics.

The aim of this paper is to spread some light over contract treatment from the perspective of the District Courts, Social Services and Probation Services, and understand the reason for local variation of the number of people sentenced to contractual treatment.Essential questions asked in this paper are; What advantages and disadvantages are known by the cooperating parties regarding contract treatment in comparison to prison? What parameters are considered when the cooperating parties decide upon contract treatment? What impact does the shared responsibility of cost have? What do the respondents think is the reason for the local variation?In order to answer the essential questions a qualitative and descriptive method has been used to highlight the main question of our study; What is the reason for the local variation in number of contract treatment sentences in Halmstad and Ystads district courts?The paper shows that the local variation between the Probation Services districts is dependent on the conditions to propose a contract treatment. In Halmstad it is not conditioned for the Probation Services to have a responsibility agreement with the Social Services to the same extent as for the Probation Services in Ystad..

In this essay the morphing of the interstate relations in the post-World War II Western Europe is taken in to consideration in discussing how these relations were stabilized and consolidated through community cooperation to achieve a state of stable peace. It concludes that the early 1900's of Western Europe comes close to being conditioned by Herz's security dilemma and then continues to analyze the development from this state to one of stable peace. In this analysis pivotal features of the ECSC, EEC and the EC are being scrutinized through the use of Boulding's Stable Peace theory and developments of the very same, in separate case studies, in order to account for the Communities? influence on the peace process.In doing this, conclusions are drawn that external pressures can be very effective in creating an incentive to move beyond an initial state of conflicting self-images and that a stabilizing process has got to provide a long term solution in order to sustain a trustful relationship. In order to provide this long term solution the community cooperations suggests that locking in through institutionalization, harmonization, and the creation of a state of irrevocable interdependence are highly effective..

High quality within a Lean production system begins with standardised work, which creates stable processes able to generate predictable output. If nonconformity from the standard procedures occurs, routines are needed to analyse, correct and prevent the nonconformity from occurring again. In that way, the nonconformity can be a trigger for continuous improvements toward more stable processes. In takted production lines, where the operator follows a standard sequence with tasks set to be completed within the takt time, a nonconformity leads to downtime in the operator?s sequence, and no value is added.

The purpose of this graduate work is to seek knowledge about how children?s right to participation and influence is interpreted and understood in a specific context and also to examine how this right can be conditioned and shaped by the pedagogical practice of early childhood education.The focus of this study has been to examine the arguments and attitudes towards the right to participation and influence as a pedagogical practice as it is understood in early childhood education. Additionally, I have been interested in studying the affordances and restrictions that early childhood educators experience when dealing with children´s right to participation and influence.The platform used for data collection is Facebook and the informants recruited were active participants in forums regarding democracy in preschool education. In the second phase of the study I conducted online focus groups with these participants.For the analysis of the material I have adopted a poststructuralist perspective, starting from Jaques Derridas philosophical texts and use of deconstruction.The results show the complexity in early childhood education´s democratic mission. What becomes clear is the importance for the teachers to adopting an open, ethical and democratic approach in order to make children´s right to participation and genuine influence possible in the everyday reality of early childhood education. .

Matrix metalloproteinaser (MMPs) är en grupp proteolytiska enzymer som degraderar komponenter i vävnaders extracellulära matrix (ECM). Dessa proteiner spelar en viktig roll i många fysiologiska och patologiska processer. Enzymerna anses vara delaktiga vid olika typer av hjärtsjukdomar där de genom att utöva sin effekt påverkar sammansättningen hos ECM. Aktiviteten hos MMPs hämmas av TIMPs (tissue inhibitors of metalloproteinases) som är enzymernas specifika inhibitorer. Balans mellan nedbrytning och uppbyggnad av ECM är nödvändigt för att bibehålla hjärtvävnadens normala struktur och funktion.

There is convincing research which shows that the enzyme alkaline phosphatase (ALP) has a central role in the mineralization of bone, more precisely that its catalytic activity is needed in the process. ALP is found on the surface of matrix vesicles where the mineral is formed. One theory about the function of the enzyme is that it binds to fibrous collagen in the bone and thereby incorporating the mineral into the bone. The purpose of this study is to establish whether ALP binds to collagen. If this is the case, more elaborate studies around this will be performed.

En operation framkallar en icke önskvärd fysiologisk reaktion hos patienten som benämns som kroppens stressvar. Stressvaret innebär att sympatiska nervsystemet aktiveras och att endokrina ändringar erhålls, bland annat minskning i sekretionen av TSH och insulin samt ökning i sekretionen av ACTH, kortisol och ADH. En viktig uppgift för en veterinär är att välja premedicineringsläkemedel innan en operation. Premedicineringsläkemedel har som främsta uppgifter att motverka det perioperativa stressvaret hos djuret, minska smärta och förstärka anestesimedlens effekt. Syftet med det här arbetet är att beskriva vad som händer i kroppen vid ett perioperativt stressvar och hur svaret kan motverkas med hjälp av premedicineringsläkemedel. Premedicineringsläkemedel väljs och kombineras från klasserna sedativa, analgetika och antikolinergika. De vanligaste använda sederande läkemedlen på svenska veterinärkliniker är dopaminantagonisten acepromazin och alfa2-agonisten medetomidin.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Introduktion Autolog stamcellstransplantation a?r idag en vanlig behandling vid myelom och ho?gmaligna lymfom hos patienter <65 a?r utan omfattande komorbiditet. Behandlingen delas upp i fem faser: induktionsbehandling, stamcellsmobilisering, stamcellssko?rd, konditionering med ho?gdoscytostatika och stamcellsa?tergivning/transplantation. Initialt behandlades alla patienter som genomgick autolog stamcellstransplantation inom slutenva?rden under den sista behandlingsfasen, det vill sa?ga i samband med konditionering och stamcellsa?tergivning.