Transdermal drug delivery, besides painfulinjections with syringes, has long been associatedwith small size particle pharmaceuticals, which candiffuse through the skin. This method of drugadministration has only been applicable on a smallnumber of drugs, where active molecules are smalland delivery time should or can be long.Other drug delivery options are oral administrationand injection with hypodermic needles (ordinaryhospital syringes). In oral administration thestomach and liver tend to dissolve the drug and theeffect becomes more difficult to anticipate, anddrug delivery rates difficult to control. Hypodermicneedles are used as a mean of drug injectiondirectly into the bloodstream. This method ispainful and risks infection due to tissue damageand skin penetration.One way to get a painless non-damaging techniquewith high delivery rate that still can delivery largemolecules is to manufacture an array of microscopichollow needles and equip them with a pumping unitthat delivers the correct amount of drugs.This thesis shows the technique and possibility ofmanufacture micromachined needles using low costtechniques of Ion Track Technology (radiation ofheavy ions creates porous materials), electrolessdeposition (non-current activated wet chemistrymethod of depositing metal) and electroplating.

Purpose The purpose of this study is to evaluate the treatment results and adverse drug effects for 14 dogs receiving a new paclitaxel preparat named Paccal vet. The evaluated dogs are chosen to enter a pharmacogenomical study. Therefore, this paper intends to give an introduction to pharmacogenomics. Finally this study also aims at finding the homologue genesequenses in dogs to seven genes that are important for metabolism of paclitaxel in humans. Materials and metods The dogs went through 2-4 cycles of paclitaxel treatment, they received a new water-soluble formula named Paccal vet, at dosages of 100-150mg/m2. Treatment results and adverse effects are listed for each dog in table 1.

In the Swedish market, there is a wide selection of herbs as supplement to the horse´s feed. A trend today is that many companies are marketing herbal remedies with allegations of medical effects. If you want to sell the product for that purpose it must be verified and approved as drug or natural remedy by the Medical Products Agency. Some herbs may contain active substances. Nevertheless, only a few studies have been conducted on single herbs to investigate safe doses for horses.

A qualitative interview study how the normative gender images affects on women, their roles and positions in a drug abuse. The purpose of this study aims to shed a light at the consequences that the normative gender scenario inflicts on women with drug abuse and how these prejudices affects these women. Based on interviews with four different women who all lived with a drug abuse we have problematized how the gender system and the normative gender images affected them. We have used gender perspectives and social constructivism theories while analyzing the empirical basis. More specifically we use the theories of Butler about how gender constructs through performative actions and Hirdmans theories of the gender system.

This thesis discusses the Swedish drug policy and its principle of prohibition. In the world of today there is an ongoing discussion about prohibition and the concept of harm reduction. This thesis is an analysis of Swedish drug policy and an investigation as to whether the prohibition concept is in a state of decline. It tries to answer the question; is the Swedish drug policy moving away from its prohibition principle towards a harm reduction principle? The recent debate, articles, documents and earlier research has been analyzed in order to find answers to my questions.

The aim of this study was to examine how the new established phenomenon of ?Internet drugs? causes challenges to organizations, both individually and in relation to collaboration. The study is based on qualitative semi-structured interviews with representatives from three organizations - one youth police unit, one medical addiction centre and four units working within social services. The theoretical approach that was used is theory about human service organizations, theory about collaboration and new institutional organizational theory. A conclusion is that the current drug classification is problematic and mainly challenging for the organizations that focus on prevention work and early interventions.

The study deals with the beliefs that relatives of alcohol and drug dependent persons, and representatives from social services have to the various forms of support available for the relatives. Those who participate in the study points out that there are many people who have a need for support as a relative of an alcohol or drug addicted individual, but that there are circumstances that make them choose not to seek assistance. The study shows that the relatives can experience a reluctance to seek support from social services because of how the organization looks like. The study is qualitative, where the collection of the empiric material has consisted in six semi-structured interviews. Three of them have been with relatives of alcohol-or drug-dependent persons and three have been with social workers in various professions, whose work consists of helping both the relatives of people with alcohol and drug dependence as well as people who are dependent.

The question formulation for this work has been "is an ice-hockey audience influenced by music during time-outs in a game?". The method was to observe one period with Färjestads BK and Mora IK, but a recording was also made, together with a conversation with the arena DJ. From the recording, the audience reactions were graded from a given scale. The grades were compilated to a diagram that shows the audience reactions in relation to the time, from the first face-off to the final whistle.

About 35 years ago the WHO advocated that countries with injecting drug users should introduce the so-called needle exchange programs (NEP) to curb the spread of infection by blood-borne diseases. In Sweden the first NEP started 1985 in Lund, but the program was extremely controversial in a country with such a restrictive drug policy like Sweden.The study you are about to read shall process this controversy, when a NEP opened in Stockholm, by analyzing the articles published in the newspapers Dagens Nyheter and Svenska Dagbladet. By using discourse analysis as a processing tool we?ll try to see the difference between the two chosen newspapers. We will identify and analyze the different participant?s, such as doctors, politicians, user associations and media, arguments in the needle exchange issue.

The purpose of this study is to understand and analyze why individuals develop and manage to leave drug abuse. The material consists of interviews with eight individuals who have gone through a life of addiction and managed to change their lifestyle. We contacted the participants through the organization called KRIS (Criminals Redress with Society). The results indicate that the participants have had a troublesome upbringing and been labeled by society as outsiders which have led them into addiction. The results also show that they have all gone through a social conversion from the life as an addict to become sober.

Working life is an arena that often reflects attitudes that already exist in our society. When alcohol- and drug abuse is detected among employees the employer has a statutory responsibility for rehabilitation. But the way how these employees gets to be treated is also influenced by attitudes. The purpose of this essay was to illustrate from a gender perspective how women's and men's alcohol- and drug abuse occur in working life and how the attitudes in our society towards their abuse reflect on trade life. Referring that, our intention was also to examine which consequences are given of how the individual is treated.

The purpose of this paper was to examine how people experience the practice of Cannabis in daily life. The study was based on interviews with five individuals who have experience with cannabis use. They do not represent a bigger population only themselves. We chose these particular individuals because all of them began using cannabis at a young age- everyone before they were twenty. But they have been using cannabis because of different reasons.

The aim of this study is to examine how young people look at and perceive drugs by studying how they discuss and reason about drugs. The essay's main interest is not whether young people use drugs or not. We are primarily interested in how young people talk about drugs. The questions that we want to get answered are:What are the beliefs that young people have about drugs, drug use and drug users? More specifically we seek answers to which images, symbols and attributes that young people links to drugs, drug use and drug users.What is important in young people's construction of beliefs about drugs and drug users? More specifically, which are the information sources and reference groups that young people assigns significance?We used focus group interviews as the research method.

The purpose of this thesis was to increase our understanding of how the social service in Sweden deals with reported incidents of addiction to medicines. Another purpose was to point out the different opinions concerning addiction to medicines amongst actors as well as possible ways to handle the problem.We have conducted a quantitative and qualitative e-mail survey targeting all communities in Sweden, with the ambition of gaining further knowledge about the role and responsibility of the social service concerning reports of addiction to medicines. Two quantitative questions were one asked about how many clients requested/were reported for needing help with their drug abuse alone, and the second question about how many clients needing help for drug abuse as a part of a wider addiction.The survey revealed that the social services judge their role/responsibility differently; some take the main responsibility while others think that drug abuse is created by the general health care and should be handled by this organization as well. In relation to the estimated amount of drug addicts in Sweden only a small part are in contact with the social service..

In this study the opioid buprenorphine was given to 8 clinically healthy goats. The pharmacokinetics and behavioral effects were studied. Injections of buprenorphine, 0.02 mg/kg body weight was given both intramuscularly (i.m.) and intravenously (i.v.) with a cross over design. The results showed a short half-life of the drug in the plasma, 65.9 ± 17.4 min (mean ± SD), after i.v. injection.