Växtföljder fick mindre betydelse för den sanerande effekten på ogräs när de kemiska bekämpningsmedlen introducerades på 1940-50-talen. Fram till sommaren 2010 hade herbicidresistens upptäckts i 194 arter i över 340 000 olika fält världen över och det är ett problem som kommer att öka i världen. Herbicider kan verka på olika sätt i växten. De flesta fall av herbicidresistens beror på en förändring på verkningsplatsen för herbiciden, men kan också bero på en ökad metabolism i plantan, dvs. herbiciden bryts ner innan den hinner göra verkan.

Cysteinproteaset cathepsin B har en trolig roll i vävnadsnedbrytningen vid kronisk parodontit då det visats kunna bryta ner extracellulära komponenter. Cystatin C är en fysiologisk inhibitor av cathepsin B och båda har kopplats till parodontal sjukdom. Syftet med studien var att undersöka närvaro av samt lokalisera cathepsin B och cystatin C i gingivala biopsier från patienter med kronisk parodontit. Närvaro och lokalisation av cathepsin Bs och cystatin Cs demonstrerades genom immunohistokemisk metod av kryostatsnittad vävnad. Polyklonal kanin anti-human primär antikropp för både enzym och inhibitor användes.

The aim of this study is to elucidate factors that effect growth of Sarcina lutea and Bacillus subtilis, exposed to the growth inhibitor SDS (Sodiumdodecylsulfat). Agar diffusion experiments revealed repeated, concentric zones of inhibition and stimulation upon exposure to Sodiumdodecylsulphate or to Amoxicillin. Temperature, nutrient concentration and inhibitor concentration were controlled. Formation of successively repeated zones of inhibition, stimulation, inhibition and stimulation is discussed: ? The extension of the primary inhibition zone is due to the concentration of applied Sodium dodecyl sulphate.? Immediately outside the primary inhibition zone the bacteria have access to diffusing nutrients that have not been consumed in the primary inhabitation zone.? In zones of dense bacterial growth the bacteria may produce inhibiting substances, affecting growth of bacteria in adjacent zones.? In zones of dense bacterial growth the nutrients will soon become depleted, thus affecting bacteria in adjacent zones..

Haemophilia is an inherited disease which causes increased bleeding due to defect clotting factors VIII and/or IX. There are two forms of haemophilia, A and B, which both are X-linked and due to mutations of the genes of factor VIII and factor IX respectively. This study focuses on Haemophilia A and thereby factor VIII.The drugs that are available on the Swedish market today for patients with haemophilia A include Factor VIII(FVIII), which has been purified from human plasma and recombinant factor VIII(rFVIII). The main goal of this study is to gain a better understanding of the effects of treatment of haemophilia A with either purified plasma factor VIII or recombinant factor VIII on reducing or preventing bleeding and on side effects.  The study was designed as a literature review and searches were carried out in PubMed at the Linnaeus University library.  The criteria for selection of articles were: patients with haemophilia, treatment with plasma derived and/or recombinant factor VIII as well as clinical studies.

Background: Diabetes mellitus is a chronic disease that manifests as an increased level of glucose in the blood. According to the World Health Organization (WHO), 347 million people have diabetes worldwide. In year 2004, 3.4 million people died from the consequences of high blood glucose. In the Swedish population the prevalence of diabetes is estimated to 3-4 %, out of which 85-90% are Type 2. Among senior citizens a prevalence of diabetes is seen in Sweden up to 14 - 15%.

Strömmar ut från metall till elektrolyt orsakar korrosion vilket försvagar metallen och kan leda till sönderfall.Det finns sätt att skydda mot korrosion. Ett isolerande skikt kan läggas mellan metall och elektrolyt för att dämpa strömmen ut i elektrolyt. För att hindra att ström alls går ut i elektrolyt kan anod och katod sammankopplas metalliskt. Vissa ämnen som kallas inhibitorer kan hämma korrosionshastigheten när tillagda i rätt mängd. Kan också mota elektroner som vill ut med elektroner in.I uppsatsen undersöks läckströmmars beteende för olika marktyper, metaller och spänningar. .

The RECK gene is a relatively new discovered gene with important implications for cancer research. The research has been primarily concentrated on the human gene with the ultimate aim to identify the invasive characteristics. Up regulated RECK is linked to significantly prolonged survival rates in patients with severe forms of malignancies. RECK is normally expressed in all cells of the body and has an important role in the balance between destructive and constructive features of the extracellular matrix. The RECK protein is a membrane-bound glycoprotein that inhibit matrix metalloproteinases which has the function of breaking down the ECM. There is a significant correlation between RECK gene expression and the formation of new vessels, presumably via the mediation of VEGF which is an important and powerful inducer of angiogenesis.

Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

Multiple factors are involved in control of beef sensory quality so great variation can be induced. The perception of meat quality can be affected anywhere in the product chain. Both the environment and the set of genes of the animals have an effect on the final output. A problem facing the beef industry today is the significant variations in meat quality between individual animals, which is reflected in the uneven quality of the meat that reaches the consumer. If the quality of meat in stores varies significantly over time, the consumers? trust may decrease.

För dagens högmjölkande kor är sinläggningen och sinperioden riskperioder för mastit. Om spenarna läcker vid sinläggningen ökar risken för att patogener koloniserar juvret och ger upphov till mastit. Mer kunskap om mjölksynteshämmare och hur de samverkar med andra faktorer som reglerar mjölkbildningen skulle kunna förbättra skötseln av mjölkkor, antingen genom att uppnå snabbare mjölksynteshämning och undvika mjölkläckage eller genom att hindra hämmarnas verkan och få en längre laktation. Det senare skulle medföra färre sinläggningar under kons livstid. Två molekyler, ?feedback inhibitor of lactation? (FIL) och serotonin, har setts hämma mjölkbildningen.

Ethanol produced from lignocellulosic biomass has the potential to become a promisingalternative to gasoline. In this work the simultaneous saccharification and fermentation (SSF)technology was applied for ethanol production from hardwood with focus on cell growth,ethanol production and contamination.The SSF was performed at PH 5.5 and 35°C for different suspended solid concentrations(8%, 10% and 12%) of pretreated birch slurry which contained 16 % total suspended solids.Two different hexose fermenting yeast strain (Ethanol Red) and pentose fermenting yeaststrain were used.Quantifying the concentration of chemical components and metabolites in the fermentationmedium demonstrated that glucose and xylose are the major fermentable sugars in the slurry.The higher load of slurry (12%) represents a higher content of carbohydrates and potentiallyhigher end concentration of ethanol. Moreover, more lactic acid is produced with the lowerload of slurry (8 % or 10 %), presumably due to a result of a less inhibitory environment forbacterial growth. In this context, acetic acid sticks out as the most important inhibitor withconcentrations of 15.2 and 12.5 and 9.7 g/l respectively in the 12 %, 10 % and 8 % (ofsuspended solids) trials. Using pentose fermenting yeast may lead to higher ethanolproduction, lower xylose uptake and lower lactic acid formation.

Lymphoma is a group of malignant tumour diseases developing in the secondary lymphatic system. These diseases can develop in all organs as lymphocytes are ubiquitously in the body. In connection to mucus membranes we find mucosa-associated lymphoid tissue, MALT, in which lymphoma can spontaneously but slowly develop, mostly at chronic inflammation or at autoimmune diseases. Today these diseases are incureable with the exception of some cases caused by Helicobacter pylori-infection. Antibiotic treatment of these cases can induce remissions.MALT-lymphomas have characteristic histological and molecular properties.

Alzheimers sjukdom (AD) är den vanligaste formen av demens och kännetecknas av intracellulärt neurofibrillärt trassel (NFT) bestående av proteinet tau och extracellulära plack, uppbyggda av peptiden amyloid beta (A?). En växande skara studier har börjat peka mot att AD är en hjärnspecifik typ av diabetes. Insulinresistens följt av hyperinsulinemi och hyperglykemi är kännetecken för diabetes mellitus typ 2 (DMT2) och har visat sig vara en riskfaktor för AD. Insulin, ett hormon som kontrollerar glukoshomeostasen i perifera nervsystemet (PNS) och är viktigt för minne och inlärning, transporteras över blod-hjärnbarriären i en mättnadsbar transportmekanism och dess koncentration i centrala nervsystemet (CNS) minskar vid DMT2 och AD.

The aim of this study was to compare the effect between the drugs rituximab and infliximab in rheumatoid arthritis (RA). RA is an autoimmune disease that affects the peripheral joints and is associated with exacerbations. Various immune reactions in the body cause inflammation of the joints which further results in cartilage and bone damage. The diagnosis is made by the classification system "The 2010 American College of Rheumatology (ACR) / European league against rheumatism (EULAR) classification criteria for rheumatoid arthritis", which is an update of the older system called "The 1987 American College of Rheumatology classification criteria for RA". Approximately 0.5-1% of the population is developing the disease, but it varies slightly between different parts of the world.

In the fluidized bed furnace at Rönnskärsverken, Skelleftehamn, sulphur-containing ore concentrates are roasted in order to remove about 50% of the sulphur in the incoming ore concentrate. This occurs in order to reach the goal of a matte containing 55% of copper in the following smelting process. At the same time as the ore concentrate is partially roasted pollutions as arsenic, antimony and bismuth are expelled. Earlier made thermodynamic calculations of equilibrium suggested that calcium and magnesium form stable compounds with arsenic and thereby inhibit expellation of arsenic in the fluidized bed furnace, an element that is undesired. The purpose of this thesis work was to gain knowledge of the mechanisms behind the formation of these stable arsenic compounds.