Lungfibros hos hund
fallbeskrivningar, histopatologi samt analys av surfaktantproteiner
LungfibrosIPFWestieWest Highland White TerrierSurfaktantSP-CSurfaktant protein CHistopatologiLungaFibrosRespiration
Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an
estimated incidence of 3-6 cases per 100 000 inhabitants in Sweden. There is no
cure for the disease, which inevitably leads to death. A similar disease has been
found among terrier dogs, with an especially high prevalence in the West
Highland White Terrier (WHWT). Dogs with pulmonary fibrosis become
lethargic with exercise intolerance, and in some cases they develop cough and
respiratory distress. This thesis gives a brief review of the field of pulmonary
fibrosis and presents a method for analyzing surfactant proteins in
bronchoalveolar lavage (BAL) in the dog. Five cases of canine pulmonary fibrosis
are presented with clinical data, histopathology and surfactant analysis. The
results show that one of the dogs with pulmonary fibrosis lacks detectable
surfactant protein C (SP-C) levels in BAL, which also has been shown in humans
diagnosed with a familiar form of IPF.