Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

Lymphoma is a group of malignant tumour diseases developing in the secondary lymphatic system. These diseases can develop in all organs as lymphocytes are ubiquitously in the body. In connection to mucus membranes we find mucosa-associated lymphoid tissue, MALT, in which lymphoma can spontaneously but slowly develop, mostly at chronic inflammation or at autoimmune diseases. Today these diseases are incureable with the exception of some cases caused by Helicobacter pylori-infection. Antibiotic treatment of these cases can induce remissions.MALT-lymphomas have characteristic histological and molecular properties.

The wood-living beetle Ceruchus chrysomelinus is a rare species connected to natural forests. In Sweden, it is red-listed as endangered (EN) and an action plan for its preservation has been done by the Swedish Environmental Protection Agency. In this work I have therefore investigated how a Translocation of the species succeeded after 17 years. I aimed to study the species dispersal biology, its substrate preferences and the supply of suitable wood on this site. The study was performed during 2012 in Pansaruddens nature reserve close to Uppsala in Sweden, which is a spruce dominated forest.

The great bustard (Otis tarda) became extinct in Sweden during the mid-19th century. Globally, populations have suffered dramatic declines during the past two centuries. Recently, local populations have stabilized or increased after hunting bans and conservation efforts. Despite positive trends the species is still classified by IUCN as vulnerable (VU), mainly due to withdrawals in the distribution. The limited distribution emphasizes the need for finding ?new? areas suitable for a Translocation or reintroduction.

Syndecan-1 is a cell surface proteoglycan which participates in cell adhesion, differentiation, motility, morphogenesis and intracellular signaling. The two glycosaminoglycans heparan sulfate and chondroitin sulfate are covalently attached to the ectodomain of syndecan-1 via a tetra saccharide linkage sequence. However, the ectodomain can be modified having only one or neither of the glycosaminglycans attached. The glycosaminoglycans are capable of binding ligands such as fibroblast growth factors (FGFs) and support activation of receptors. The ectodomain is proteolytically cleaved from the cell surface by metalloproteinases in a process known as shedding.

The Swedish wolf population is like continue to grow and this will eventually lead to an increase in the predation of livestock. In Sweden carnivore attacks happen most frequent on sheep farms and the majority of these attacks are performed by wolves. Because of this, the main focus in this study is on the sheep and wolf problematic. It is not only the direct killing of livestock that affects the animals and their owners in a negative way. It has also been shown that livestock that lives close to carnivores sometimes change their behaviour in a way that will affect their ability to reproduce and to forage efficiently.

This master thesis has been a pilot study preceding a forthcoming project of a larger scale with the long term objective to separate the direct effect of added nitrogen on soil processes from indirect effects via trees. The aim of this study has been to investigate the allocation of nitrogen following direct injection of liquid solutions into the xylem of 40 year old Norway spruce. The field site is located at Flakaliden (64°07?N, 19°27?E), approximately 60 km northwest of Umeå, Sweden. A total of 18 trees were selected for treatment, equally divided between three treatments, potassium nitrate, glutamine and water (control).

Rörelsemönster och habitatanvändning hos ormar är ett område där relativt lite forskning har gjorts trots tecken på minskande populationer på flera platser i världen. Snoken (Natrix natrix) är en vanligt förekommande orm i Sverige som tycks vara på nedgång, troligen på grund av en sämre tillgång på äggläggningsplatser. Vanliga äggläggningsplatser i Sverige utgörs av gödselstackar och komposter vilka ger den stabila temperatur som äggen behöver. Dessa har dock blivit både färre och mer svårtillgängliga under det senaste århundradet. Huvudsyftet med denna studie var att undersöka vilka äggläggningsplatser som används i ett område där gödselstackar saknas och hur anpassningsbara snokhonor är till nya områden.