The development of IT systems is usually accomplished by some form of system development methodology. It can be performed as the waterfall method, where each phase is completed before the next begins. One of the reasons to follow a development methodology is that the process is more structured, faster and that the product will have higher quality. One risk of not using a system development approach is that the code can be unstructured and difficult to maintain.This paper describes an alternative method in which the development occurred without the use of any system development methodology. This has been possible because there was a clear goal of the program that should be developed.

Bringing back the nutrients from the city to the country is becoming increasingly important, as the world?s stores of nutrients get more exhausted. Sewage sludge is an unapplied resource, rich in plant nutrients, which could replace parts of the commercial fertilizers used in Sweden today. Sewage sludge may contain large amounts of pathogens, such as Campylobacter and Salmonella, why use can cause severe spreading of infections, both to animals and humans. These pathogens have the ability to survive for a long time in soil and water and therefore some sort of treatment of the sludge is recommended before use.

The present study discusses the metabolism of ethanol in the human body from the ingestion of ethanol to the excretion of its break down products water and carbon dioxide. Ethanol is a small Molecule, soluble in water as well as in organic solutions. It is quickly distributed to every section in the body, where it exerts a direct toxic effect on the cells. Ethanol cannot directly leave the body efficiently so it needs other metabolic pathways. The Molecule is metabolized by oxidation, predominately in the liver.

Starch is a naturally occurring substance in most plants and is used as energy storage. It is a component that mainly consists of amylose and amylopectin. Together they build a complex pattern which gives starch its specific properties. The proportion of amylose and amylopectin varies in different plants but generally starch consists of 25 % amylose and 75 % amylopectin. There have been discoveries of barley varieties containing 100 % amylopectin called ?waxy starches? or ?waxy barley? as well as varieties that have a high content of amylose, around 70 % and these are called ?amylotypes?.

In this study we have interviewed eight teachers about when and how particle concepts should be taught. All of the surveyed teachers argue for an early introduction. This view is also consistent with the scientists on when the particle concepts should be introduced. By an early introduction teachers and scientists consider the age between 6-12 years old. A majority of the scientists and the surveyed teachers use concept of change as a entery point to talk about particle ideas.

Glutathione (GSH) is a Molecule that consists of three amino acids: glutamic acid, cysteine and glycine. GSH has several important functions: to protect cells from free radicals, reactive oxygen species and oxidative stress. GSH exists in a reduced form, GSH, and in an oxidized dimeric form, glutationdisulfid, GSSG. The enzymes glutathionereductase (GR) catalyses the reduction of GSSG back to GSH. Nicotinamide adenine dinucleotide phosphate (NADPH) is required as a coenzyme in the reaction.

Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the Molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

Cirka 300 000 individer drabbas årligen i världen av oral cancer och mer än nittio procent av alla orala cancerformer utgörs av skivepitelcancer. Den femåriga prognosen är generellt 50 % och den 5-åriga relativa överlevnaden har under en tioårsperiod förblivit densamma. Detta motiverar utvecklingen av bättre prognostiska markörer och diagnostiska metoder för att tidigt identifiera de patienter som har risk att utveckla oral skivepitelcancer för att förbättra prognosen och minska lidandet genom tidig insatt behandling. ?-catenin är en adhesionsmolekyl som är viktig för bibehållandet av cellulär integration och avvikelser i celladhesionsmolekyler tros spela en central roll när tumörceller invaderar närliggande vävnad det vill säga metastaserar till andra organ. Syftet med studien är att med hjälp av immunohistokemi undersöka om ?-catenin kan fungera som en prognostisk markör för utvecklingen av oral skivepitelcancer.

Osteoartrit (OA) är en vanligt förekommande sjukdom och bidragande faktor till nedsatt förmåga att träna och tävla hos hästar. Ledinflammation som det också kallas drabbar alla häst raser och i alla grenar inom rid, trav och galoppsporten. Inflammationen kan drabba alla de ingående strukturerna i leden och ger kliniskt upphov till hälta, smärta, ökad ledfyllnad och stelhet. Sjukdomen bidrar till sämre djurvälfärd och ekonomiska förluster inom hästindustrin. Orsakerna kan vara många.