Equine metabolic syndrome (EMS) it?s a clinical condition that includes obesity, regional adiposity, insulin resistance (IR) and laminitis. A similar syndrome exists in human medi-cine, the metabolic syndrome (MS), were systemic hypertension also is a prominent fea-ture. The systemic hypertension seen in humans with MS is partly due to a vascular endo-thelial dysfunction with an enhanced Endothelin-1 (ET-1) mediated vasoconstriction. There are indications that systemic hypertension might be a feature in EMS as well but if ET-1 is involved in the development of the systemic hypertension in horses is not known.

Pyometra, chronic purulent metritis in metoestrus, is a common disease in intact bitches. About 25% of all bitches in Sweden have contracted the disease before ten years of age. Clinical signs of the disease are varied, and the course may be either slow or acute. The diagnosis is most commonly made by radiographical or ultrasonographical examination of the abdomen in combination with blood biochemical and hematological analyses. The safest and most efficient treatment of pyometra is surgical ovariohysterectomy.There is room for improvement of both diagnostic tools and possible prognostic indicators for pyometra.Mast cells are large leucocytes, with granule that contain inflammatory mediators.

Fetma är ett tillstånd som har visat sig öka risken för utvecklandet av metabolt (MS) syndrom hos människa. MS karaktäriseras av fetma (framförallt bukfetma), insulinresistens (IR), diabe-tes mellitus och högt blodtryck. Idag anses fetma även vara en av orsakerna till utvecklandet av ekvint metabolt syndrom (EMS) som ses hos hästar. EMS liknar till stor del den sjuk-domsbild som ses hos människor med metabolt syndrom. Förutom fetma är regionala fettan-sättningar och IR vanligt förekommande hos dessa hästar som ofta även utvecklar fång.