The aim of this master thesis was to examine a possible connection between chromatin functions and the DNA damage repair system, with the imprinted IGF2/H19 locus as a bait. Interactions can occur within and between chromosomes and it has been shown that H19 ICR on both alleles can communicate with alleles on other chromosomes. The methylation-sensitive insulator protein CTCF is bound on the maternal H19 ICR and acts as an insulator by blocking the IGF2 promoter to access its enhancers. This is possible by formation of loop structures by CTCF that enables intra and inter-chromosomal interactions. CTCF is poly(ADP-ribosyl)ated by PARP-1 when it is bound to H19 ICR.

Fruit flies (Tephritidae) are serious pests that cause enormous losses for farmers in many countries. The frequent use of insecticides in controlling fruit flies in fruits and vegetable has not resulted in sustainable management of the pest. Problems associated with this complete reliance on chemical control are many residues of insecticides in crops, health problems for farmers, contamination of water and soil, insecticide resistance development and decrease in natural enemy populations. The implementation of control measures that do not imply an added burden to the environment and/or the farmers is urgent. More knowledge about the ecology of fruit flies is the basis for finding new and better ways to control this pest.

Avyttringen och ombildningen av kommunala och privata bostadshyresfastigheter till bostadsrättsföreningar har blivit ett allt vanligare fenomen under de senaste decennierna. Främst sker avyttringen i Stockholms kommun. Syftet med denna uppsats är att mäta om prissättningen vid utförsäljning av bostadshyresfastigheter inom Stockholms kommun skiljer sig beroende på om säljaren varit privat eller ett allmännyttigt kommunalt bolag. För att undersöka detta har olika regressionsmodeller applicerats på data över fastighetsprisregistret under två mandatperioder. Resultatet visar en tydlig prisskillnad mellan kommunala avyttringar och privata inom samma områdesindelning.

The purpose of this investigation was to find out more about students? spontaneous ideas about properties and transformations of matter. Examples of matter chosen are such which students know about from everyday life and focus is mainly on the questions if students know that all matter has weight and that matter is preserved in transformations.The method used is semi structured qualitative interviews with individual students. Different experiments were carried out together with the students who afterwards were interviewed. However, the students show varying answers and no generalizations can be done.

Syftet med denna studie är att titta på det vi vet om dopamins roll i aptitreglering idag, både generellt och med ett veterinärmedicinskt intresse specifikt på hund. Dopamin är transmittorsubstans i flera nervbanor i hjärnan och dess frisättning har traditionellt kopplats starkt till att positivt förstärka nyttosamma upplevelser eller handlingar i det som kallas kroppens ?belöningssystem?. I relation till föda och födorelaterade beteenden har man dock på senare tid sett att dopamin har en bredare betydelse än att enbart förstärka själva födointaget. I litteraturen syns därför ett fokusskifte mot ett vidare perspektiv med hänsyn till dopamins alla, nu kända roller ? något som väckt insikten om det dopaminerga systemets komplexitet och frågan om det ens är möjligt att få en helhetsbild över alla dess funktioner. Denna litteraturstudie har undersökt delar av ett stort litteraturmaterial fram tills idag och konkluderar att trots mycket forskning är dopamins exakta funktioner i aptitregleringen fortfarande inte klarlagda utan det verkar fortfarande råda ovisshet och oenigheter.

The purpose of this article is to explore the technologies of government that are created within gender disorder assessments as an institution. I have done so by utilizing Norman Faircloughs discourse analysing instrument ?communicative action?, which focus on the social institution as relational.The material is strategically chosen by gathering texts from the Swedish state, the psychiatric clinics, NGO:s and by performing interviews with transsexual patients.When analysing the communication of the main agents, I have concluded that practices highly are a result of repeating text and speech inside the institution. The psychiatric assessments can also be seen as an illustration in changes in how citizens are governed in advanced liberal societies, where the role of the state has been gradually reduced in favour of other agents.I consider that the change illustrates an ?acting at a distance?-mentality where the patient is introduced to participate in the definition of the care in what I call ?negotiation as a technology?.

Intelligent IT-based solutions, often called Smart Grids, are considered to be the future balancers of renewable energy sources. One area within the Smart Grid concept is called demand response, which is focused on making customers more consumption flexible by making them more active in their consumption. In this thesis the aim is to analyze a business model by investigating the income potential for a demand response solution as well as its market potential. This has been done through literature studies, interviews and development of a computational model.The use of 5000 households with flexible consumption can provide a cost reduction of 17.2% or 2.4 million SEK for a balance responsible party during an average year. If the solution is used to make strategic bids on the regulation markets the study indicates that the largest potential for revenues lies within this strategy.

Today evidence exist that environmental chemicals deteriorate male sperm quality and that testicular cancer is increasing. Bisphenol A (BPA) is a chemical with estrogenic effects used in the manufacture of polycarbonate plastic and are found in, for instance, plastic boxes, feeding bottles and food containers. Much of the research on how men's reproductive ability is influenced are performed on rats. This review article complies how male rat reproduction is affected by BPA as a model for humans. Studies have investigated how sperm are affected, hormonal changes during reproduction and how reactive oxygen species (ROS) affects sperm.

Enligt Svenskt Vatten ska dagvattensystem vara dimensionerade för att klara ett regnmed en återkomsttid på 10 år. För att utvärdera om ett system är rätt dimensionerat kanen dagvattenmodell upprättas. Det är då viktigt att veta vilka nivåer ledningarna har mendenna information är bristfällig hos många kommuner. Ledningarna borde dock följatopografin i generella drag och borde därför kunna uppskattas därifrån.Syftet med denna studie var därför att utveckla en metod för hur vattenledningarnasnivåer kunde ansättas på ett enkelt sätt utifrån marknivån och hur stor betydelse detskulle ha vid dagvattenmodellering. Ett ytterligare syfte var att även bedöma Lidingöstads dagvattensystem, där information om ledningarnas nivåer saknades, utifrån dennametod.

The purpose of this paper is to examine how events can be successful and stay competitive.Festivals are a big part of the event world and it can be difficult to understand why certainfestivals are successful and others not. In this paper we have conducted a comparison betweentwo major festivals in Stockholm. Both of them reached success, but nevertheless one of themfailed, while the other one is still successful. With this comparison, it appeared that there aremany aspects that help a festival to reach success but also factors that can make a festival afailure. To conduct this study, a number of interviews have been carried through; these havelater been put in relation to different theories about festivals.

Det har aldrig tidigare gjorts några studier som kopplar ihop utseende med sömnbrist. Det är väl känt att sömndeprivation påverkar hälsa. Tanken att attraktivitet också skulle bli negativt påverkat kan baseras på studier som visar att ett friskt utseende och hudkvalitet har effekter på attraktivitet. Förmågan att avgöra om en person är trött utan signaler från beteenden har heller inte tidigare blivit undersökt. I den här studien fotograferades 23 deltagare vid ett baselinetillfälle och efter 36 timmars sömndeprivation.

The purpose of the study is to examine what effects the law has on principals? approaches to mandatory reporting of child maltreatment (Social Services Act 14:1§). Moreover, the aim is to study if the regulation gets the impact intended. To respond to the purpose, legal science methods in the form of sociology of law were employed aided by qualitative semi-structured research interviews. The interviews comprised six principals in six different schools in the Stockholm area.

Hemoplus® (Sarstedt, Nümbrecht, Tyskland) is a guaiac-based fecal occult blood test developed for human medicine. Guaiac-based tests make use of the pseudoperoxidase activity of hemoglobin so the test is not specific for human hemoglobin and can therefore be used in veterinary medicine. Peroxidase-containing foods such as meat (hemoglobin and myoglobin) can cause false-positive results of the test. To ensure that a positive result is not caused by diet, it has been suggested that canine patients should be fed a meatless diet for a few days prior to fecal occult blood testing. The aim of this study was to evaluate the effect of commercial dog food on guaiac-based tests. In this study fecal samples from healthy dogs were analyzed with Hemoplus®.

This thesis investigates the regulation of hybrid work environments by focusing on the implementation of rules by both management and employees. It examines the methods used to measure compliance and the consequences of non-compliance within organizations. The study also explores how flexibility in work arrangements and the balance between work and personal life affect employee well-being and productivity. Furthermore, it highlights the critical role of self-leadership in navigating the complexities of hybrid work, emphasizing how effective self-management can enhance organizational efficiency and employee satisfaction. We have adopted a qualitative research approach and interviewed employees, managers, and HR personnel with experience in hybrid work. The different perspectives are expected to provide insights into this area by including all levels within an organization It is evident that organizations that have clearly established rules and guidelines regarding hybrid work have achieved the best desired results.

Lime Hempcrete consists of lime, water and hemp and creates an insulating, sound-absorbing, lightweight and environmentally friendly material that can be used in wall, roof and floor structures (Bevan & Woolley 2008). This construction method is not yet developed in Sweden as there has been a ban on the cultivation of the hemp plant. This ban on the cultivation of hemp was removed in 2003, when the material got a boost. You can use it in many different ways and not just in the construction industry (Ahlsten, 2010).In this study we have investigated the possibility to produce prefabricated wall elements of LHC. We have also studied its mechanical properties and dehydration time.