The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

Malign hjärntumör är en vanlig sjukdom som ger olika former av symtom beroende på var tumören är lokaliserad och behandlingsformerna kan ge olika komplikationer. Det finns inga tydliga riktlinjer för hur omvårdnaden kring patienten med malign hjärntumör ska bedrivas. Syftet med denna studie var därför att sammanställa ett kunskapsunderlag angående omvårdnadsåtgärder för patienter med malign hjärntumör. Metoden som användes var en litteraturstudie i form av en granskning av vetenskapliga artiklar, vårdprogram, kandidat- och magisteruppsatser och böcker. Resultatet visade vem, hur, var, vad och när information ska ges till patienten.

Svordomar och lånord är vanligt förekommande i kommunikationssituationen kring datorspelande. Syftet med studien är att undersöka dessa och identifiera deras funktion, samt hur kommunikationen påverkas av att handla om både datorspelsvärlden och världen utanför.Analysmetoden bygger på kategorier som utarbetats av tidigare språkforskare. Materialet utgörs av transkriberade inspelningar av fyra grupper datorspelande ungdomar. Resultatet visar ett flitigt användande av både svordomar och lånord.De lånord som är specifika för spelen visade sig vara relaterade till strategi och unika företeelser för respektive spel. Det faktum att datorspelsvärlden och verkligheten krockar resulterade i ett intressant användande av personliga pronomen samt samtalsämnesväxling som influeras av världen utanför datorspelet.

The project aimed to develop a protective and stabilizing insole called Trailplate for soft andlight shoes. The demand came primarily from off-road runners in France, Switzerland, andAustria. The project was carried out at Icebug, a company that develops shoes mainly forrough terrain. The main focus has been on the trailplate which is designed to fit severaldifferent shoes.Torsional stiffness and bending resistance were the main objectives. To improve the existinginsole, a material with the right features was required.

Today, some kind of laboratory results is required for around 70% of the diagnostics and follow-ups for diseases. In many of the cases the time from sampling to a result is very critical. Therefore the discussion of how to improve this situation has begun. For many analyses serum has been the routine choice for a long time but now it is disputed. After blood collection in a serum tube it is essential to wait 30-60 minutes before centrifugation and analysis of the sample, a long time for someone in an acute state.

Nematode-transmitted plant viruses (such as nepoviruses) cause great economically losses in commercially important plants such as tomatoes, grapevines and raspberries all over the world. To avoid spread of the viruses the interest in mapping the viruses has increased. One of the important nepoviruses infecting European red raspberries (Rubus idaeus) is Tomato black ring virus (TBRV). TBRV has earlier been confirmed in raspberry samples from Belarus by ELISA and the aim of this bachelor degree project was to confirm these results by amplifying, cloning and sequencing the coat protein (CP) gene of the virus. In total eight viral cDNA samples, from two different raspberry samples, were amplified and sequenced.

Bakgrund: Varje år drabbas ungefär 1100 personer i Sverige av en hjärntumör. Symtomen som uppstod innan diagnosbesked upplevdes som mindre allvarliga, men under behandlingen blev symtomen svårare. Hjärntumören påverkade hela patientens livsvärld. Det var sjuksköterskans ansvar att stötta patienten och att hjälpa patienten att uppnå livskvalitet. Hoppet var ett existentiellt grundvillkor som hjälpte människor att skapa mening med livet.

Serum thymidine kinase 1 (TK1) activity is used as a tumor marker in disease monitoring in veterinary and human medicine. TK1, an intracellular enzyme, is involved in a salvage pathway of DNA precursor synthesis. TK1 is used in DNA precursor production by catalyzing the transfer of the gamma-phosphate-group from a phosphate-donor to the 5?- hydroxyl-group of thymidine forming thymidine-monophosphate. Nucleoside monophosphosphates are finally converted into thymidine-triphosphates. TK1 activity significantly rises in the G1 and the S phase of the cell cycle.

Titel Det mänskliga ledarskapet ? Hur verksamhetschefer inom äldreomsorgen leder, motiverar och belönar sin personal Författare Elin Hansson, Anna Latomanski, Maria Ågren Frölander Handledare Bo Markulf, Veronica Åberg Problemformulering Behovet av personal inom äldreomsorgen kommer inom den närmaste tiden att öka drastiskt. Stora pensionsavgångar, få unga som vill utbilda sig till undersköterskor och en stor grupp äldre som ska få plats på landets olika äldreboenden står som bidragande orsaker. Hur ska äldreomsorgen kunna locka nya medarbetare till en organisation som idag inte framstår som attraktiv? Vilken roll har ledarna inom organisationen i detta? Och vilken roll spelar den ökande konkurrensen mellan den privata och kommunala sektorn? Syfte Syftet med denna uppsats är att se hur verksamhetschefer inom äldreomsorgen leder, motiverar och belönar sin personal.

This master?s thesis deals with integrating simulations using Agilents Electronic Design Automation tool ADS with customized Matlab scripts, for solving complex analog and digital radio architectures. In particular, it addresses predistortion, realized in the digital domain, of power amplifiers, modeled in the analog domain. The former is implemented in Matlab while the latter is implemented in ADS. Two versions of integrating the two systems have been tested: 1) Iterative approach on sample basis and 2) Scheduled batch solution by matrix inversion.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

Rotavirus and coronavirus are the two most common viral causes of neonatal calf diarrhea and their presence causes a lot of economic damage to the farmers as well as suffering to the animal. By getting better knowledge about the viruses we may help in tracing transmission and in producing new vaccines. This paper served to study the molecular epidemiology of rotavirus and coronavirus in fecal samples collected from two different farms in the state of São Paulo, Brazil. These samples have been studied with focus on the gene VP4, VP7, NSP4 in rotavirus and the gene S1 in coronavirus. From the first farm the screening PCR showed that 12/48 samples were positive for rotavirus and 4/48 positive for coronavirus.

The municipality of Kalmar have a problem, how to reach and communicate with young people in Kalmar. In today?s changing media environment it gets more difficult to stand out and reach audience with messages and especially with the new forms of media that has revealed. Therefore, we have been commissioned to develop recommendations on how the municipality of Kalmar can communicate with young people in Kalmar.  The purpose with this study is to investigate which media channels young people in Kalmar use and their attitudes towards social media in particular. We wanted to find out how the municipality should communicate to reach them and what attitude youths have against the municipality in general.

The customer behavior is constantly changing along with the developement of new technical improvements. Together with knowledge and higher demands the physical store has received a viral competitor. Purpose: The purpose of this study is to examine the phenomenon e-commerce and how it has developed in recent years. The study will focus on identifying different success factors relevant for this field of interest. Furthermore the purpose is to analyze how relationships, service and value in the e-commerce sector and how they are connected to each other.

In the years 1996-2001 the European Union`s copyright-directive was drawn up. This directive led to much lobbying activities from both copyright holders and library organisations like EBLIDA and IFLA. The Internet and filesharing networks like Napster had led to strong reactions among some copyright holders. Internet gave people an easy opportunity of accessing copyright protected material. Some researchers of copyright have written books where they state that the copyright holders utilize authors fear of illegal copying to strengthen the copyright laws, and by that benefit economical.