Leber´s hereditary optic neuropathy (LHON), a disease affecting vision, is caused by several point mutations in mitochondrial DNA. Mutations leading to a defect NADH ubiquinone oxidoreductase protein will affect the respiratory chain and cause a disturbed ATP production. It is still unknown why this defect leads to the degeneration of retinal ganglion cells and cells in the opticus nerve as well as demyelination of axons in these areas. Analysis of mitochondrial DNA is an important tool in the diagnosis of the disease. At the present time analysis is based on cleavage by restriction enzymes, which only detects two of the most frequent mutations: m.3460G>A and m.11778G>A.

The purpose of this thesis is to present and describe which criteria, according to the systemfamily Configuration Management, should be met when developing a CM-tool to handlemigration data.ACT is a tool developed by Microsoft to gather information about, analyze, test and mitigateapplications in a network when migrating the IT-infrastructure of an organization to a newoperating system. The organization that is being studied wants to present the data about theanalyzed applications in such a way, that a customer can choose what to mitigate and migrate.The goal is therefore to develop a prototype (CM-tool) that will present this data.The study has shown that ACT lacks certain requirements stated by the organization when itcomes to presentation. But when it comes to the rest of the functions, ACT performs as expected.The investigation resulted in specifications and technical solution for the new CM-tool. CMcriteriafor migration data was put forth and parts of the prototype were also developed..

Gender mainstreaming has been an internationally dominant policy since the mid 1990?s. In 2004, the Swedish government decided to implement gender mainstreaming within the Government Offices of Sweden. However, little research seems to have focused on the reasons for an organization's decision to implement gender mainstreaming. Consequently, the purpose of this study is to answer the question why the Government Offices of Sweden have decided to use gender mainstreaming.

Typically, when Faurecia in Torsås are planning a new assembly line, one of the steps is to build a full-scale model of the line in card board, a form of mock-up planning. Faurecia has shown interest in finding an alternative methodology. The purpose was to explore the possibility of replacing today's cardboard based mock-up planning with models in a digital simulation environment.The purpose of the thesis has been to answer some of these complex questions; What are the benefits of using a simulation tool? In what way can we use it? If we choose to use a simulation tool, in what way does it affect our way of planning an assembly line? What are the advantages and disadvantages? Are there any economical and social aspects?Our results made us realize that a digital simulation tool does not replace the card board. On the other hand simulation could be used as a complement.

The essay examines and compares three different textbooks used in gymnasieskolans A- course from a postcolonial perspective. The method used in the essay is a qualitative analysis. Edward Said?s postcolonial theories are used as a tool to facilitate the analysis of the textbooks. The purpose of the essay is to examine how the textbooks depicts different parts of the world, are they depicting a multicultural world view, or are the textbooks assuming a western perspective in their description of the world.

Internet of Things är ett samlingsbegrepp för den utveckling som innebär att olika typer av enheter kan förses med sensorer och datachip som är uppkopplade mot internet. En ökad mängd data innebär en ökad förfrågan på lösningar som kan lagra, spåra, analysera och bearbeta data. Ett sätt att möta denna förfrågan är att använda sig av molnbaserade realtidsanalystjänster. Multi-tenant och single-tenant är två typer av arkitekturer för molnbaserade realtidsanalystjänster som kan användas för att lösa problemen med hanteringen av de ökade datamängderna. Dessa arkitekturer skiljer sig åt när det gäller komplexitet i utvecklingen.I detta arbete representerar Azure Stream Analytics en multi-tenant arkitektur och HDInsight/Storm representerar en single-tenant arkitektur.För att kunna göra en jämförelse av molnbaserade realtidsanalystjänster med olika arkitekturer, har vi valt att använda oss av användbarhetskriterierna: effektivitet, ändamålsenlighet och användarnöjdhet.

Bakgrund: Den svenska produktionsindustrin hotas utav så kallade låglöneländer som kanerbjuda samma tillverkning med en högre lönsamhet. Detta gör att verksamheten måste varaattraktiv för såväl investerare som kunder vilket gör att företaget måste genomföra ständigaförbättringar för att klara konkurrensen. Detta är något som även Xylem i Emmaboda kännerav. Xylem tillverkar ett brett utbud av dränkbara vattenpumpar men även annan utrustningsom krävs för att leverera vattenteknologi. Tidigare studier på en utav Xylems verkstäderOPX har visat att produktionen lägger mycket tid på aktiviteter som inte är värdeskapande såsom materialhantering och andra förflyttningar genom fabriken.Syfte: Syftet med uppsatsen är att identifiera var det kan finnas slöserier genom att utföra enValue stream mapping på en utav Xylems verkstäder i Emmaboda.Metod: Arbetet består av en fallstudie med explorativt syfte som utförs genom en Valuestream mapping.

Every year more than 6000 thefts, to a value of 1.5 billion SEK, are reportedwithin the Swedish building trade. Plus all the indirect costs of having theconstruction site standing still.SafeTool is a newly started company that will try to prevent this problem witha modern technology solution.The key to SafeTool?s solution is RFID ? Radio Frequency Identification ? andthe solution looks like this;All tools are stored in a container on the construction site. Every tool isequipped with a RFID-tag that uniquely identifies the tool. With antennas in thecontainer it is possible to detect when a tool is leaving the container and whenit comes back.

This Bachelor Thesis in the area of Computer Science and Work Science describes the process of design and development of an IT-tool between the municipality of Ron-neby and TietoEnator a development and consultancy firm, the Gothenburg office. The thesis focuses mainly on the cooperation between the consultant designer and the local municipal. Through cooperation, the organisation is incorporated into the tool and the tool is incorporated into the organisation. Concepts that are central in this thesis are design, cooperation and tailoring. A question raised is, if distance work and extensive cooperation might be a good way of working in the process of design and development, when the organisation is being incorporated into the tool.

REINERTSEN AS performs expansion and buckling analyses of pipelines using ANSYS, afinite element modelling and analysis tool. In an expansion analysis the pipeline is modelledwith thin?walled pipe elements called PIPE20 which allows plastic deformation. However, ina recent analysis the results retrieved from the PIPE20 element were incorrect for strainsabout 1 percent. One main issue was that the PIPE20 element overestimated the strains.The purpose with this Master Thesis was to become familiar with the theories and analysismethods used in pipeline design.

Due to a growing interest in communication in today?s society the demand for equipment that is used in communication networks increases while the competition between companies that produce this equipment grows. To meet the increasing demand and at the same time having a competitive product development many companies use some effective product design, such as the modular product design. When a modular product design is used it?s good to compare different module configurations for a certain product and to simplify these comparisons some tool can be used.

This report describes the process of outlining a design proposal for a resource planning tool for TV post-production. A feasibility study in form of a participant observation has been carried out on-site, which has resulted in a requirement specification. Based on the requirement specification, mockups have been created to illustrate the functions and features that a final planning tool should have. In addition to developing a design proposal, an evaluation of the existing resource planning tool Ganttic has been conducted. Ganttic has been reviewed based on how well it meets the list of requirements.

The aim of this thesis is to contribute to increased knowledge concerning students? information seeking in an electronic environment. Using a qualitative approach; focus groups interviews, a total of nine nursing students were interviewed in two groups. The interviews were transcribed and analyzed with an analysis tool based upon Lucy Kuntz?s, Gary Marchionini?s and Carol C Kuhlthau?s models of the information seeking process.

Background: The demand for sending letters, in the traditional aspect, has decreased because of electronic sources which have replaced a big part of letter communication. The Postal Service constantly strives for lowering costs and due to the changeable demand, a greater awareness is required regarding recourses and their usage. The previously mentioned measures in combination with commonly occurring quality issues during the collective process at the letter terminal in Alvesta would be improved by applying a lean-perspective to the process. A first step towards saving of time is to apply the ?value stream mapping?-method on the collective process for small and large letters.Purpose: To map the process of collection for small and large letters to be able to identify waste of recourses and furthermore give suggestions on how the Postal Service would be able to reduce the waste of recourses identified.

This is qualitative study of, four teacher´s views on the use of iPad in teaching and learning. In addition, I will examine the disadvantages and advantages of iPad use as a teaching tool in preschools.My questions are:What is the practical use of tablets in preschools today?Are preschool teachers using the tablet as a teaching tool? If so, how?Is the use of tablets in preschools contributing to children´s social interaction, as well as between children and teachers` social interaction?The purpose of this study was to find out how the four teachers uses the iPad as a teaching tool in the interaction between children in preschool. I have chosen to use Vygotsky?s and John Dewey´s theories.