Den insulinlika tillväxtfaktorn II (IGF II) är ett proteinhormon som reglerar cellers proliferation, tillväxt, migration, differentiering och överlevnad. Den utövar sin biologiska funktion via IGF I-receptorn. Dess tillgänglighet för bindning till IGF-1R regleras av en familj bestående av sex IGF-bindarproteiner (IGFBPs). IGF II kan också inducera mitos via en alternativt splitsad variant av insulinreceptorn (insulin receptor isoform A (IR-A)). De cirkulerande nivåerna av IGF II kontrolleras genom IGF II-receptorn, som saknar signalfunktion och är homolog med mannos-6- fosfatreceptorn. Tystad prägling av IGF II-genen är en återkommande observation vid en utvecklingsrubbning kallad Beckwith-Wiedemanns syndrom, vilket innefattar okontrollerad tillväxt och i många fall en njurtumör hos barn, Wilms? tumör. Tillväxthämning ses vid mutationer i genlocuset hos IGF II och den närliggande genen H19 vid en annan utvecklingsrubbning, Silver-Russells syndrom.

People with chronic fatigue syndrome and their experience and need for care referred to Barbro Gustafsson's theory of acknowledgement and the SAUK-model..

People with Aspergers syndrome (AS) have proven difficulties maintaining jobs according to previous research. This is a quality study. Four women with AS were interviewed about their experience of employment. What difficulties and contributions have they experience at work? What is the self experienced need of support within the research group? The result has been analyzed with different types of ?support?.

White-Nose Syndrome, WNS, is an emerging fungal disease in the Northern American bat population causing mass mortality in infected hibernacula. Geomyces destructans is a newly discovered psychrophilic fungus causing WNS but the pathogenesis and epidemiology of the disease is not yet fully clarified. Geomyces destructans has been found in Europe but has not been a cause of mass mortality there. This study is the first investigation done to see if G. destructans is present in Sweden.

Tårsubstitut används mycket bland linsbärare och personer med torra ögon. Detär vanligt nuförtiden att arbete i kontorsmiljö och vid datorer ger problem medtorra ögon, Computer vision syndrome (CVS), och att dessa personer dåanvänder tårsubstitut. Ofta står det i tårsubstitutens bipacksedel att de kan geproblem med dimsyn en stund efter applicering.Tidigare studier har visat att aberrationerna i ögat ökar vid applicering avtårsubstitut och möjligtvis är det anledningen till att dimsynen uppkommer.Syfte: Syftet med studien är att ta reda på hur mycket synkvaliteten påverkas avtvå olika tårsubstitut och hur lång tid den påverkas.Metod: Metoden innebar att närvisus och aberrationer mättes på 30 patienter (60ögon) först utan tårsubstitut. Sedan applicerades det första tårsubstitutet(Systane) i höger öga och ytterligare en mätning av närvisus och aberrationerutfördes. Därefter gjordes ytterligare 5 mätningar av aberrationerna, en var fjärdeminut.

The aim of the study was to explore the methods used in horticultural therapy gardens in rehabilitating people suffering from fatigue syndrome. Nine horticultural therapy gardens were contacted of wich three chose to participate. Using case study as method e-mail interviews was carried out with the participants about their establishment and what kind of theories they based their methods upon. The material collected from the interviews was complemented with additional data from the establishments web pages and information pamphlets. Collected data was processed trough content analysis and then formed as background for the development of a program theory for horticultural therapy.

Introduction: Reversal of a temporary loop-ileostomy is the final step after a long treatment for rectalcancer, an event that the patient has been looking forward to for a long time. Studies have shown that patients often have a significant impact on the bowel function after reversal of the stoma.Aim: To describe how the patient experienced the first time at home after reversal of a temporary loop-ileostomy due to rectalcancer. Method: Qualitative semi-structured interviews, with 15-20 patients who have undergone reversal of a temporary loop-ileostomy due to rectal cancer, will be conducted. The interviewes will be analysed using qualitative content analysis according to Graneheim & Lundman (2004). The patients will be recruited from the colorectal unit at Sahlgrenska University hospital/Östra and from the surgical unit at Kungälvs hospital.

The purpose with this work is to describe the language that is built around the chronic fatigue syndrome (CFS) in Sweden. Our questions are: What does the professional field look like; who writes, about what and for which kind of readers? How do they describe the expressions and the upcoming of CFS? For which reasons can CFS be considered as a medical diagnosis/illness? How can CFS be understood from a social perspective? Our theoretical starting point is a social constructive theory and also Karin Johannisson's theory about medicalization and Foucault?s theory about power. We have from a literature-exposition of Swedish articles from 1989 to 2006, done a social constructive discourse analysis with help from Laclau & Mouffe's discourse theory, and Fairclough's model of social practices. In our textual analysis we found three dominating discourses: A medical discourse, a social/cultural discourse and a general/popular discourse.

Nature and garden have always had meaning in human's life and succesfully seen as having health giving effects. Health is a state of equilibrium between physical, psychological, social and spiritual well-being. The individual's health is depending of how the society looks and how the individual manages to live her life in it. Stress is one of our time's large public health problems and leads in some cases to burned out syndrome. Stay in nature gives recovery according to theories of environmental psychology.

The purpose of this literature review is to describe nurses supportive function to families who lost their child in Sudden Infant Death Syndrome (SIDS).

Cannabis är narkotika och omdiskuterat, särskilt när det gäller dess medicinska användning. Många rykten florerar om mot vad det kan användas till och ett flertal individer med olika sjukdomsbakgrund självmedicinerar sig med Cannabis. Cannabinoider som extraheras från Cannabis kan vara användbara för behandling av en rad olika sjukdomar. Detta arbete fokuserar på att ge en exposé av Cannabisalkaloidernas medicinska värde för personer som upplever smärttillstånd och dess terapeutiska effekt vid sjukdomarna Multipel Skleros (MS) och Parkinsons. Metoden som användes var en litteraturstudie och databaserna PubMed och Cochrane har använts för att ta fram informationen.Studien är baserad på fem artiklar, av vilka två fokuserar på smärtlindring, en på muskelstelhet i samband med MS, en på dyskinesi hos patienter med Parkinsons och en på tics hos individer med Tourettes syndrom.Smärtlindring noterades både i studien där patienterna led av HIV-orsakad smärta och i den neuropatiska smärtstudien.

Equine metabolic syndrome (EMS) it?s a clinical condition that includes obesity, regional adiposity, insulin resistance (IR) and laminitis. A similar syndrome exists in human medi-cine, the metabolic syndrome (MS), were systemic hypertension also is a prominent fea-ture. The systemic hypertension seen in humans with MS is partly due to a vascular endo-thelial dysfunction with an enhanced endothelin-1 (ET-1) mediated vasoconstriction. There are indications that systemic hypertension might be a feature in EMS as well but if ET-1 is involved in the development of the systemic hypertension in horses is not known.

Studien är gjord i form av en kvalitativ studie där syftet är att genom berättelser från personer med Aspergers syndrom förstå vilken betydelse just detta funktionshinder kan ha för skolgången. Studien bygger på livsberättelser från en kille och en tjej som beskriver sin syn på sitt funktionshinder samt vilka svårigheter och möjligheter de har stött på under skolåren. I studien redovisas även relevant litteratur om Aspergers syndrom och olika metoder samt strategier läraren kan använda sig av i undervisningen. Dessa metoder och strategier kan bilda en grund för strukturering och planering av skoldagen och skolmiljön så att eleverna får det stöd deras funktionshinder kräver och sina behov mötta. Resultatet visar att tydlighet och struktur är viktiga delar för personer med Aspergers syndrom.

In Sweden there are laws and recommendations from The National Board of Health and Welfare about the importance of a user's involvement in and possibility of influencing services directed at them. Even with such good intentions the same board reports that it is hard to know if people experience that they do. The purpose of my study was to examine how professionals can use their knowledge to help users increase their sense of influence in services that they use. My focus has been on adults with neuropsychiatric disabilities within the autistic spectra, such as Asperger syndrome, and on the professionals working with them. The specific problem among people with neuropsychiatric disabilities is a lack of social skills.

This study has been made to evaluate if there is a significant difference between non-estral intact versus ovariohysterectomized queens in their production of estradiol after exogenous gonadotrophin-releasing hormone stimulation. The purpose is to find a tool, which can help to diagnose if a free-roaming queen is already ovariohysterectomized or not. There are also other situations where this tool could be useful, for example to diagnose the ovarian remnant syndrome. Previous studies in bitches have shown that GnRH-stimulation is an excellent tool to diagnose the presence of ovaries in the bitch. Eleven ovariohysterectomized and eleven intact queens have been included in this study where we have analyzed plasma estradiol and progesterone concentrations before and after a single intramuscular injection of the GnRH agonist buserelin (Receptal?).