Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.

In this paper we have examined why seniors do not use e-business to the same extent as other age groups. Seniors belong to the age group that, according to statistics from Statistics Sweden (SCB) in 2011, utilizes e-business the least in relation to the number who use the internet. To understand how seniors reason and perceive the possibility to shop on the internet, we have conducted four interviews with people from 65 years and older. We have let the respondents answer questions regarding utility aspects, e-business interfaces, general shopping habits, risks, and whether or not they usually shop online. We also found out how seniors reason when they sell products and services.

This masters thesis concerns a modeling project performed at Volvo Technology in Gothenburg, Sweden. The main purpose of the project has been to develop a physical model of the climate in construction vehicles that later on can be used in the development of an electronic climate controller. The focus of the work has been on one type of wheel loader and one type of excavator. The temperature inside the compartment has been set equal to the notion climate. With physical theories about air flow and heat transfer in respect, relations between the components in the climate unit and the compartment has been calculated.

Outages in the electric grid can be costly for society. Because of this, reliability is one of the parameters used to regulate network companies. Reliability in electrical grids can be measured with SAIDI, system average interruption duration index, which for Fortum Distribution has increased in Stockholm?s distribution network (11 kV) in the early 2000?s.By using outage data for Stockholm from 2011-2013, sets of parameters to be used for reliability calculations in the network information program Tekla NIS were derived. Two different options for investment were then analysed: changing old cables with high fault frequencies, and installing automatic switching in distribution substations.

This master thesis consists of the creation of shock absorber models for percussive rock drills. A model of the rock was also developed. These models were connected to existing models of the rock drill to create a complete simulation of the rock drilling process.When the models had been created the rock model was evaluated by comparison with measured values from lab tests. The verified rock model was then used to evaluate the shock absorber models.Four new shock absorber concepts have been developed. Three of these have been modelled, while the fourth have only been sketched and described.The evaluation of the models showed the following:? Simulations of the single shock absorber don?t correlate to reality very well.

Purpose ? The purpose of this thesis is to develop a total cost model for container transports and create a tool that calculates a suitable transport quantity from an economic view, which fulfills the demands on delivery service. To achieve this purpose the following questions will be answered:Which costs are affected by the decision between the two transport alternatives LCL and FCL?   How does the decision of sending product LCL or FCL influence the delivery service?  How can a tool be constructed to simplify the decision-making process regarding the choice of sending products LCL or FCL?  Method ? A total cost model was developed. This model is supported from existing literature.

The development that the Swedish society has experienced during the last four decades and the higher part of the population coming from foreign countries calls for a more intensive research on the situation of these groups. The purpose of this study is to find explanations of the differences in the share of immigrant politicians in Linköping and Norrköping. The starting point of the study is a model of factors assumed to affect the representation of immigrants in the municipality assemblies. The immigrant composition, the municipality organization and the view of democracy of the politicians, are all assumed to affect the civic participation. The civic participation is then assumed to affect the representation of immigrants in the municipality.

Denna rapport beskriver arbetet med utvecklingen av en ny modell för kaplanturbiner. Utvecklingen bygger på två kopplade differentialekvationer som under arbetets gång anpassats och implementerats i turbinmodellen.Modellen beskriver hur vattenflöde och turbinmoment påverkas av avvikelsen från den optimala kombineringskurvan för vinklarna på turbinens ledskena och löphjul, och är anpassad för ett referensaggregat med tillgängliga provdata. Även övriga enheter i vattenkraftaggregatet modelleras och sätts samman med frekvensregulator och elnät för att simulera aggregatets reglerstabilitet i önätsdrift.Verifieringen av turbinmodellen sker genom försök att återskapa de befintliga verkningsgradskurvorna med hjälp av modellen. Resultatet visar en god följning av de verkliga kurvformerna, dock med något lägre maximal verkningsgrad.Verifieringen av önätmodellen sker genom att prova stabiliteten i nätfrekvens och turbineffekt vid stegpålastningar. Resultatet ger en stabilare reglerstabilitet än i verkligheten, men uppfyller ändå förväntningarna på en fungerande modell.This report describes the development of a new kaplan turbine model.

Prior studies have shown that earnings management can be used either to inform or to mislead investors about the future performance of a company. However, few studies have examined the impact of earnings management on forecasting return on equity (ROE). The aim of this thesis is to investigate whether the ability to forecast next year's ROE is improved when taking earnings management, measured as discretionary accruals, into account. This is examined by comparing a forecast model that takes the magnitude of discretionary accruals into consideration with a model that does not. The study is based on companies that were listed on the Stockholm Stock Exchange during 2002-2012.

The New National Elevation Model (NNH) is a new high-resolution digital elevation model (DEM) of Sweden from airborne laser scanning. It creates many new opportunities, particularly in the area of flood mapping. NNH is provided by Lantmäteriet in two formats, both in raw LIDAR (Light Detection and Ranging) data and in grid format with two meter resolution. These alternatives have advantages and disadvantages and the aim of this thesis research is to identify these. One of the focuses of the study is data storage and thus data structure analysis, resolution and storage facilities. The research questions are:Why and in what context the different NNH-products from the National Land Survey are used (DEM 2+ or point cloud)?What constraints and opportunities are created by the different options, mainly in terms of different software, resolution, and data storage?The study area is Kärsön in Ekerö municipality located in Stockholms län and has an approximate area of 25 square kilometers. The study is divided into two parts. The first objective is to identify the consequences of using different software to create DEM from pointcloud compared to the DEM2+ model. Height models with a two meter resolution are created in FME and ArcGIS. The models are then compared with the grid from Lantmäteriet, created in TerraScan. The second objective is to examine the impact of the change in resolution, both the storage aspect and both the accuracy aspect. Inverse Distance Weighted (IDW) is an interpolation method which in previous studies proved to have the best results on high resolution LIDAR data. This model was tested and compared with a model from FMEs built-in function and the model from Lantmäteriet wich are based on triangulation (also proved a good method in previous studies). The grid created in TerraScan has good properties such as accuracy.

Increasing volatility and less political intervention from the CAP in the market price of wheat is making it more difficult than in the past for Swedish farmers to determine the price at which they should sell their wheat. In the past, the Swedish farmer-owned company Lantmännen has traditionally set a guideline price for Swedish wheat every year to which farmers could adapt, but ceased doing so last year. Therefore this study sought to identify the parameters on which the price of wheat is dependent on by using a reduced form model. The perspective adopted was that of farmers. The model proved able to identify the main factors determining the annual price fluctuations in wheat, with all variables included having an impact on the wheat price, except export quantity in the previous year.

In 2005 Gunhild Eriksdotter published Behind The Facades in which she analyses the ways of approaching historical buildings in archaeology. Eriksdotter emphasizes that the archaeology of buildings is in dire need of renewal videlicet the traditional outlook on buildings as two-dimensional objects need to change. She develops a method of analysing the spatial dimensions in a three-dimensional world. By fusing theories and methods in excavating archaeology and architecture, she is able to give us a new way of approaching buildings. Her method includes the analysing of a buildings material, spatiality and use.

As IT service departments in organisations are becoming more complex and customised, the indirect costs are increasing in relation to the total costs. The difficulty of fully estimating and identifying the spread of the cost in the IT service department is increasing. As a result, firms tend to budget the business unit as a total cost rather than as a spread of defined costs. In order to deal with this challenge an ABC calculation will be applied. The Time Driven ABC model will be conducted in OMX´s Servicedesk unit within the IT services.

Denna rapport beskriver arbetet med utvecklingen av en ny modell för kaplanturbiner. Utvecklingen bygger på två kopplade differentialekvationer som under arbetets gång anpassats och implementerats i turbinmodellen.Modellen beskriver hur vattenflöde och turbinmoment påverkas av avvikelsen från den optimala kombineringskurvan för vinklarna på turbinens ledskena och löphjul, och är anpassad för ett referensaggregat med tillgängliga provdata. Även övriga enheter i vattenkraftaggregatet modelleras och sätts samman med frekvensregulator och elnät för att simulera aggregatets reglerstabilitet i önätsdrift.Verifieringen av turbinmodellen sker genom försök att återskapa de befintliga verkningsgradskurvorna med hjälp av modellen. Resultatet visar en god följning av de verkliga kurvformerna, dock med något lägre maximal verkningsgrad.Verifieringen av önätmodellen sker genom att prova stabiliteten i nätfrekvens och turbineffekt vid stegpålastningar. Resultatet ger en stabilare reglerstabilitet än i verkligheten, men uppfyller ändå förväntningarna på en fungerande modell.This report describes the development of a new kaplan turbine model.

Denna rapport beskriver arbetet med utvecklingen av en ny modell för kaplanturbiner. Utvecklingen bygger på två kopplade differentialekvationer som under arbetets gång anpassats och implementerats i turbinmodellen.Modellen beskriver hur vattenflöde och turbinmoment påverkas av avvikelsen från den optimala kombineringskurvan för vinklarna på turbinens ledskena och löphjul, och är anpassad för ett referensaggregat med tillgängliga provdata. Även övriga enheter i vattenkraftaggregatet modelleras och sätts samman med frekvensregulator och elnät för att simulera aggregatets reglerstabilitet i önätsdrift.Verifieringen av turbinmodellen sker genom försök att återskapa de befintliga verkningsgradskurvorna med hjälp av modellen. Resultatet visar en god följning av de verkliga kurvformerna, dock med något lägre maximal verkningsgrad.Verifieringen av önätmodellen sker genom att prova stabiliteten i nätfrekvens och turbineffekt vid stegpålastningar. Resultatet ger en stabilare reglerstabilitet än i verkligheten, men uppfyller ändå förväntningarna på en fungerande modell.This report describes the development of a new kaplan turbine model.