Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

At the end of 70s and the beginning of 80s, 18 terminals was built and used for chipping wood residue from clear cuttings. Most of the terminals was terminated before the 2000s but with the high oil- and energy prices that we can see today there might be a place for these terminals again. The goal with the study was to analyze and compare economical differences between 5 different logistical systems, collected data was used with a set of formulas. The systems include long range transport of slash, chips and bundles. Three of the systems include transport by lorry to industry the last two includes a terminal with access to train transport.

This study focuses on a cooperation (collaboration) project between municipalities social services and the regions psychiatric care. They will capture a client / patient group that often risks falling between the chairs, persons with a psychic disorder and a problem of substance abuse. The purpose of the study was to study the projects cooperation on its organizational level. The central questions of issue were: What is cooperation in the project? What view do the professionals have of the projects cooperation, and partly have on members of the client group persons with a psychic disorder and a problem of substance abuse? The study was implemented through participating observations on three meetings with the govern group, the project group and the POS-team and interviews with two representatives from each principal.

The study aims to describe how art teachers conduct their teaching towards the new curriculum requirements, hence, to the must-haves of society towards the art education. As a future art teacher, I have an interest in finding out how the art teachers tackles the new requirements despite substance plight. The study has revealed that resources for the art education, both financial and time varies from school to school. Which says something about a very unfair situation for the teachers..

ABSTRACTStandardized assessment instruments have increasingly come to be used in social work. Although national studies of ASI and DOK's reliability and validity has only been examined to a limited extent. In order to improve knowledge of assessment instruments conditions, relevance and scope, this present literature study highlights the background and the application of the interview methods ASI and DOK, used in swedish abuse and dependent care. In answering the survey questions, a qualitative content analytical method has been used. ASI and DOK are multidimensional interviews which take into account that several areas affecting the client's treatment outcome.

The purpose of the study is to investigate the significance of organizing social- cooperative in relation to individual empowerment; and how this empowerment can be used to better the situation of others. Young surfers is a social- cooperativ that is run by cooperators with experience of substance abuse and criminality. The social- cooperativ is built on the premise that the cooperators are to set up and run a screen-printing shop where they will print t-shirts and sweatshirts. The purpose of this business is that the cooperators are given the opportunity to work and that youths with social problems such as substance abuse and criminality are given the opportunity to work-train. My study is comprised of a series of interviews and observations that I have conducted in relation to the cooperators of Young Surfers.

The purpose of this study was to investigate how an ADHD diagnosis late in life as an adult can have effected childhood and adult life. It is a qualitative study executed by interviewing four adults, two men and two women. The individuals in the study had all experienced difficulties in their childhood and in school and had all felt different from the rest of the ambient. None of the interviewees were on medication for ADHD but most were open for trying. Support from school or other settings had been minimal.

This thesis has been performed at Clinical Chemistry at Sahlgrenska University Hospital in Gothenburg. The purpose of the project was to investigate new and alternative ways to determinate synthetic cannabinoids by gas chromatography-mass spectrometry. Currently, the possibilities to quantify synthetic cannabinoids are very limited. This can lead to an increased use of synthetic cannabinoids as the risk of detection is low, which may be known by drug users. The synthetic cannabinoids are sold mixed with different herbs and have varying names like Spice Gold, Spice Silver, K2, Smoke and Pot-pourri.The synthetic cannabinoids analyzed were JWH-018 and JWH-073, which are commonly found in seized Spice material.

Previous research shows that women who are victims of intimate partner violence and also have asubstance abuse have difficulties getting access to services to aid with their experience of violence.This study has examined social workers experiences of working with women with these problems,what types of services are provided and how their service needs are assessed. The study has ahermeneutical approach and the data consists of interviews with nine social workers in lines ofwork that come into contact with women in the previously described client group. The data hasbeen analyzed using content analysis. The result of the study indicates that women who are victimsof intimate partner violence and also have a substance abuse do not get their needs provided forthrough the current services in the field of social work. These women are described as havingcomplex problems and are therefore in need of more and other services than those currentlyprovided.

The aim of this study was to examine the view of social service workers on the secondary housing market based upon their work with social investigations regarding people with a difficult substance abuse. The foundation of this study rests upon a phenomenon, which according to other scholars, occurs in the secondary housing market in Sweden. The secondary housing market consists of a multitude of housing projects that social services provide for people who are homeless. The phenomenon is that the secondary housing market contains a number of demands aimed at the clients who live in these housing projects. If a client fails to live up to the demands it can sometimes lead to negative consequences which results in an exclusion from the housing projects.

The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

In some cases there are no methods to identify raw material which are included in dietary supplements such as tablets. The identification can be done with TLC. A general method description was developed using the raw material gotukola and appel cider vinegar. This includes processing to achieve higher concentration of the active ingredient if needed; evaluation of solubility agents to dissolve the active substance; evaluation of mobile and stationary phase and visualization of the stationary phase. The report also includes an evaluation of stationary plates..

People with severe mental illness and co-occurring substance abuse are an especially vulnerable group in society as health care for those is shared between municipality and county council. There is an associated health need of this target group so the interaction of the social services and the psychiatric care is of great importance. However, there are shortcomings in this interaction with results in that people with dual diagnosis do not always receive adequate care. Diverse knowledge and explanatory models may create problems for the interaction as they include different ways to define, understand, explain and deal with a problem. The purpose of this study was to examine how the interaction between the social service addiction treatment and the psychiatric care is, concerning people with dual diagnosis, focusing on how their respective knowledge and explanatory models affect the interaction.

Studiens syfte var att försöka belysa kvinnors situation i missbruksbehandling där män och kvinnor deltar i samma behandlingsgrupp. Frågeställningarna var: (1) Hur har kvinnornas liv som missbrukare sett ut? (2) Hur ser kvinnornas könsrelationer ut i behandlingen? (3) Vad innebär det att vara kvinna i en blandad könsgrupp under behandlingen? Studien genomfördes i form av kvalitativa intervjuer med en fenomenologisk hållning, och tolkades sedan med hjälp av meningstolkning. Resultaten analyserades med hjälp av könsperspektivet samt det psykodynamiska perspektivet. Resultaten visade att kvinnors situation i en blandad könsgrupp kan vara komplicerad och att både kvinnor och män lätt blir distraherade av varandra.

During the last 50 years the production of milk per cow has increased. This has, however, been followed by a decreased reproductive performance. Shorter and more indistinct signs of oestrus make it harder for the Swedish farmers to discover when the cows are in oestrus. There is a need for ways to control reproduction. The use of pheromones could possibly provide means to satisfy this need.