The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

Abstract Many researchers in social work believe that in today's society require the interaction between organisations takes place on social problems. This study examined the interaction between the police, social services and schools.The purpose of this study are as follows; the aim is to investigate the interaction between social services, the police and schools about young people aged 12-18 years who are at risk for abuse and crime.My questions are: How do the different professions interact regarding young people at risk for abuse and crime? How do they meet young people in their daily work? What obstacles can the different professions see in interaction? What effects do the different professions see in interaction?The study is a qualitative study conducted with semi-structured interviews. Respondents have been two from each organisation.The theory used in the analysis of empirical data is new-institutionalismen. New-institutionalism is a theory developed from organizational theories.

In some cases there are no methods to identify raw material which are included in dietary supplements such as tablets. The identification can be done with TLC. A general method description was developed using the raw material gotukola and appel cider vinegar. This includes processing to achieve higher concentration of the active ingredient if needed; evaluation of solubility agents to dissolve the active substance; evaluation of mobile and stationary phase and visualization of the stationary phase. The report also includes an evaluation of stationary plates..

The aim of this study has been to take part of six ex-alcohol addicts? narratives about their lives with starting-point in which factors that has been significant and/or determining to be able to leave a life in abuse and what change this process has implied for their identity. To achieve the purpose with this study has three questions been formulated. These are what in the person?s life have been important in the process of a life free from alcohol, what were specific and decisive that effected the decision to stop using alcohol and what is the attitude to them self and their new role as an ex-alcohol addict. Alcohol is a drug that is legal and accepted in the society and it´s hard to discover an addiction.

The overall aim was to examine how the public interest to protect children from violence and sexual abuse at home, is realized by social workers. The study´s central focus was the risk assessments as Social services are obliged to do when they receive a report containing concern that children are being exposed to violence or sexual abuse at home. The study addresses the following questions:o How do social workers go about practically, and what support and knowledge is being used to determine whether the Social services need to intervene for the protection of a child?o What risk and protective factors are taken into account by social workers in the assessment process?o What contextual factors do social workers experience are affecting them in the assessment process?o Which support does the documentation system BBIC provide in the assessment process?The study material was collected through qualitative group interviews, with a modified vignette methodology as tools. The study included a total of twelve social workers, with varying numbers in each interview group.

Children in vulnerable life situations An interview study of teachers' knowledge to interpret the signals of child abuse.

Our main purpose has been to describe and compare two community's ways of organising and executing the social welfare sectors drug and alcohol abuse programs. We also wanted to explain the similarities and differences we found with the help of an organisations theoretical perspective. A second purpose has been to try to find out if the difference affects the clients possibility to receive equal care.To find out how the community's organise and execute their drug and alcohol programs, we interviewed two social workers in leading positions in Landskrona and Ängelholm. We have further more, to find out if the differences we found influencing the clients possibility to recieve equal care, completed an inquiry with fictional cases that all of the involved social workers, at each community, built an opinion upon.Our main result showed more simmularities than differences in our two community's ways of organasing and executing their drug and alcohol programs. We judged the clients possibility to adequate care to be equally sufficient no matter where he sought care, since our study showed that the social workers choice of approach did not differ significantly between the two communities, even though we found differences in their way to organise and execute the social welfare sectors drug and alcohol abuse programs..

This Master's thesis explores representations of sexual agency in contemporary, Swedish novels for young adults. Using a representational theory approach the thesis analyzes 24 novels published in 2000 ? 2013. Addressing the following research questions: how is sexual agency constructed and regulated relative to gender performativity in Swedish novels for young adults? How are situations of sexual abuse and sexual ?grey zones? (situations that border on abuse) represented and being made intelligible in the texts? What are the consequences of representations of sexual agency? In the readings of the novels discourse analysis and theories on cultural representation and power have served as the critical points of entry, as well as the methodological basis for the study.

AbstractTitel: Hjälpen till ett drogfritt liv- En kvalitativ studie om återfall och återfallsprevention.Writers: Jonna Håkansson och Louise Hag.Keywords: Abuse, addiction, relapse, relapse prevention.   Abuse is a major problem and leads to negative consequences for the individual, such as illness, criminality and death. It?s also a big problem in the society, because the most common crimes are drug-related and the consequences lead to high economic costs. In order to overcome an addiction, treatment is often required.

This is a qualitative study designed to investigate how professional support group leaders talk about their role as supervisor of support groups for children and adolescents with problematic home situations. We also examine how these supervisors talk about the method they use and how they talk about the individual child. We have chosen critical discourse analysis to help us explore if there are different ways to talk about these territories. Our questions are:How does the support group leader talk about his role?How does the support group leader talk about the method?How does the support group leader talk about the individual child?The theories we have chosen to use in the analysis of our material is Aaron Antonovsky's Sense of Coherence and social constructivism.

Inom det vetenskapliga fältet för kvinnligt och manligt missbruk beskrivs ofta att kvinnan har andra och mer komplexa behov än mannen. Mannen och hans sociala situation, problematik och behov har generellt beskrivits som norm. Socialsekreterare grundar sina bedömningar och beslut på föreställningar om vad kvinnor och män har för specifika behov. Dessa föreställningar produceras och reproduceras genom rådande diskurser som verkar inom denna specifika sociala domän. Denna studie undersöker vilka centrala diskurser som kan identifieras i socialsekreterares föreställningar om kvinnligt och manligt missbruk, samt hur dessa verkar och reproduceras samt vad det kan få för implikationer för den sociala praktiken.

This paper aims to study, from a legal dogmatic method, the Swedish legislation on fixed-term work related to the EU directive 99/70/EC1. In particular, the directives demand to prevent abuse of frequent temporary employment.An employer may, in agreement with the Swedish legislation combine different types of temporary employment, to prolong the time in the temporary employment. In this proceeding an employer can avoid employing an employee in a permanent position. For example, an employee can be employed in a probationary period of six months, in a general temporary employment for a maximum of 24 months, and thereafter in a temporary position for a maximum of 24 months before the employment turns into a permanent position. This provided that the employments were made by the same employer, and within five years.

During the last 50 years the production of milk per cow has increased. This has, however, been followed by a decreased reproductive performance. Shorter and more indistinct signs of oestrus make it harder for the Swedish farmers to discover when the cows are in oestrus. There is a need for ways to control reproduction. The use of pheromones could possibly provide means to satisfy this need.

2007, Swedish television, ?Uppdrag granskning,? aired their story about ?Louise? from Vetlanda. A drug dependent father had gotten custody of his daughter and sexually abused her from the age of 10 to 15. The local social services got several notifications about Louise suffering of negligence, and did investigate the family several times without taking any actions to protect her. At one time, father and daughter were living in his trailer placed in a gravel pit, and the police worried about her and called social services, because it was below cero degrees outside.

Syftet med uppsatsen är att undersöka vuxna barns personliga erfarenheter av att ha vuxit upp med missbrukande föräldrar och deras syn på stöd och hjälp. Kvalitativa intervjuer genomfördes med vuxna barn i åldrarna 25-35 år som vuxit upp med minst en förälder som missbrukat alkohol. Resultatet visar att missbrukets omfattning och karaktär beskrevs och uppfattades på lite olika sätt. Gemensamt var dock upplevelsen av att missbruket påverkade relationerna och samspelet negativt i familjerna. Familjelivet beskrevs som kaotiskt och oförutsägbart av flera intervjupersoner, bråk och konflikter förekom ofta.