Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.

Tidigare studier har indikerat att extroverta personer använder mobiltelefoni mer än vad introverta personer gör (Inyang et al. 2010). En enkätstudie genomfördes för att testa sambandet mellan personlighetstyp och huruvida en frekvenspreferens gällande brukandet av mobiltelefoni eller portabelt ljud förelåg. Hundra stycken deltagare svarade på enkäten som bestod av tre delar. Fyra hypoteser var formulerade; extroverta förutspåddes vara flitigare brukare av mobiltelefon än introverta, medan introverta förutspåddes vara flitigare i brukandet av portabelt ljud.

Under de senaste åren har den mobila tekniken i stort sett helt gått över till smartphones. Smartphones är i princip mer datorer än telefoner, som vi alltid bär med oss och som innehåller allt mer känslig information. Detta medför att kraven på säkerheten kring enheten ökar. Detta arbete undersöker om det är möjligt att finna en ny metod att låta användaren autentisera sig på, som är säkrare än de som är vedertagna idag, men samtidigt har liknande nivå av användbarhet. Vår idé, som vi arbetar med under namnet Colour a Symbol, baseras på att kombinera symboler och färger i par.

The market for biofuels from the forests have had a positive development and the job initiators for this master´s thesis wanted to examine the profitability of a method for harvesting forest fuel, which was unfamiliar to them. The method was the ?long tree tops-method?, here called the LT-method. The LT-method is characterised by the fact that timber is harvested as the only roundwood assortment while the rest of the stem, which in other cases would become pulpwood, is harvested as forest fuel together with the logging residues. The method is based on the assumption that advantages in handling of the forest fuel assortment such as increased load weights for forest hauling and truck transportation, should compensate for the lower price for pulpwood when sold as forest fuel. The aim of the study was to compare the profitability of the LT-method with the GROT-method (harvest of timber, pulpwood and logging residues) and conventional logging without any harvest of forest fuel, and aslo to try to identify factors affecting the profitability of the different methods.

I denna rapport framgår vilken energibesparing som är möjlig i vissa processer hos Ankarsrum Industries. Hypotesen var att sänka företagets energikostnader med 30 %.Företagets analyserade stödprocesser omfattar tryckluft, belysning och ventilation och lokalkomfort. Tryckluftsproduktionen kostar idag 259 000 kronor om året. Företaget har ett tryckluftsläckage som uppgår till 113 000 kronor. Om läckage tätas och en ny kompressor investeras kan företaget spara 160 000 kronor per år.Belysningen i företagets lokaler består av flera olika typer av armaturer med varierande kvalitet.

Idag, inte bara i Sverige, bygger man mer och mer i betong. Betongkonstruktioner ses inte längre som något kallt, grått och tråkigt då man kan uppföra byggnadsverk som inte bara är starka och tåliga utan även med originella former och färger. För att få betongen stark, inte bara i tryck måste så gott som alla konstruktioner dock armeras på ett eller annat sätt. Dessa nya och ofta komplicerade former på konstruktionen ställer nya krav på armeringsmetoden som används, trots detta har sättet att armera i stort sätt sett likadant ut i många, många år.I den här rapporten kommer man att utreda möjligheterna för en ny typ av armering att etablera sig på en mycket konservativ marknad där utrymmet för utveckling och nytänkande är till synes mycket litet.Jämförelser mellan traditionell armering och denna nya cellarmering har gjorts, framförallt med avseende på projekterings- och utförandenivå. Detta har gjorts genom intervjuer med sakkunniga, både ute på byggarbetsplatsen och i armeringsverkstad.

Modern forest owners are very familiar with forest management and forest economics. Therefore they have high demands for quality in forest operations. Guarantee of quality in the shape of self-checking activities is an important tool to guarantee a well managed forestry operation. To meet the forest owners? demands on guarantee of quality and the entrepreneurs wish of an easy method for self-checking, the forest owners association, Södra skogsägarna, has developed a new method for thinning inventory. The purpose of this study is to evaluate the method that is used for self-checking and to find ways to develop and improve of the method. The data has been collected by inventory in a number of stands with circle-area survey and with strip survey, which is method that is used for self-checking. The results show that the strip survey does not diverge more than ±10 % in measuring values of basal area, number of stems, roads share, thinning quotient, outtake of basal area and total volume compared to circle-area survey.

In Sweden, harvesting pre-commercial thinning (PCT) stems for energy purposes is a interesting way of financing the high cost of preparing dense stands for a profitable first conventional thinning. This concept can be labelled bioenergy thinning. The aim of this study was to quantify the productivity of a Vimek 404R light harvester with an accumulating Naarva-Grip cutting head during the bioenergy thinning of a self-regenerated stand west of Sunnansjö in Dalarna. The stand was birch-dominated, contained 15 371 stems/ha, and measured on average 4,6 cm Dbh and 7 m tall. Even though the driver was well experienced with the machine, the stand in question was the first one that he ever thinned in this manner. Nevertheless, the driver strived to accumulate as many stems as possible during each crane cycle and chose to cut taller stems in half so as to make the handling and forwarding of the harvested stems easier.

Linux is a growing operating system in embedded systems. Today, Linux is not only in heavy servers but also in cell phones, PDAs, cameras and other devices running on battery power. While current technology is more energy efficient, more and more technologies are implemented into a single unit resulting in an overall increase of power consumption.Low power consumption is an increasingly important feature of a system today. Lower power consumption means lower costs, less environmental impact, and longer life for applications that runs on batteries.This work compiles methods to reduce power consumption of Linux systems. The work includes examining whether the available opportunities are platform-specific or of a more general nature.

The purpose of this study is to analyze the phenomenon of ?electronic bullying?, and furthermore to describe how this phenomenon is perceived by teenage girls with language disorders in combination with autism spectra. The conclusions and result from this study is derived from six in-depth interviews, thereof four being with girls with autism spectra diagnosis and all but one diagnosed with language disorder in addition (referred to as main respondents). The two reminding girls neither had language disorder nor autism spectra (referred to as comparing respondents). They were added to the study for the purpose of comparing their experiences and descriptions of those with language disorder and/or autism spectra diagnosis. For interpretation and analysis of study result, I have applied the method of phenomenology.                              The study?s main respondents had own experiences in the area of electronic bullying, albeit their level of knowledge of the subject were very limited and they had problems to interpret information given.

The aim of this thesis is to examine the archivist's professional role in public authorities and discuss if, and in what way, the profession is effected by the new swedish process oriented archival description system. The study focuses on swedish authorities and does not make any international comparisons with other institutions. Neither does it investigate archivists workingin the private sector, but centers on public institutions.The survey is performed in five swedish public authorities, using interviews and observations. Grounded theory is used as a method initially in the purpose of keeping an open mark towards the object of study. The initial results led on to questions about how well the archivists perceived that communication within the authorities served, and how this in turn prepossessed their work situation and the professional roles in which they found themselves.

The society of today is dependent of secure transports and deliveries of electrical power. Interruptions in different activities because of fallen trees cost a great deal of money in form of reparations and claimed damages for transport companies and electrical suppliers. Fallen trees along some railway sections are a severe problem. For instance, to repair the damages of the storm of week 5 year 2002, costed 2 800 000 SEK for the line region of Hässleholm. Today, the Banverket railroad company has no norms in general for how close to the railway the forest is allowed to grow.

There have previously been very few studies of forests on Seram Island in the Eastern Indonesian archipelago and none before on lowland limestone primary forests. The COLUPSIA project on collaborative land use planning has therefore chosen Seram as one of two project sites. The objective of the COLUPSIA project is to establish collaborative and equitable land use planning. In order to achieve its objective the COLUPSIA project aims to improve understanding of traditional resource management and how it interacts with governmental systems, as well as enhancing knowledge about tropical landscapes and ecosystem services.The aim of this study was to contribute to the COLUPSIA project through describing lowland limestone forest on Seram Island in respect to (1) forest structure, (2) tree species richness and (3) tree species composition. We set up 5 plots, each of 0.2 ha, at one site, Mawalai, and collected data on tree variables (tree diameter ?10 cm) as well as for some other life forms and environmental data.

Alternativ splicing av pre-mRNA ger upphov till proteindiversitet. Histonmodifieringar kopplas till den alternativa splicingens reglering genom adaptorsystem som overfor den epigenetiska informationen direkt till splicingfaktorerna. De cis- agerande RNA- elementen pa exoner och introner med tillhorande trans- reglerande splicingfaktorer paverkas darfor direkt av specifika histonmodifieringar. En sammankopplande integrerad modell over en rad DNA- baserade processer foreslas. Denna komplexa modell ger en bild av interaktioner och paverkan mellan dessa delar.

Inom skogsnäringen sker idag en omfattande strukturomvandling. Från att ha varit en fragmenterad bransch med många små aktörer går nu företagen samman i internationella koncerner. Bland kooperativa företag sker även en utveckling mot alternativa former av kooperativa företag. Dessa bildas för att bättre möta omvärldens krav. Bland annat ägar-strukturen är under förändring genom att externa ägare bjuds in i olika utsträckning.