Scrapie is an infectious neurologic disease in sheep caused by prions, corresponding to transmissible spongiform encephalopathies (TSEs) in other species. The prion is presumably constituted of PrPSc, the misfolded form of the normal endogenous prion protein, PrPC, which is found in practically all cells in the body. PrPSc can induce a conformational change in PrPC and misfold it as an imprint of itself; this is how prions amplify and spread. The process of conformational change is poorly understood and there might exist intermediate forms between PrPC and PrPSc. Bioassay using mice has traditionally been the golden standard in prion studies but is limited by cost and time.

In order for construction projects to be completed within the specified time limit while at the same time be financially sustainable it requires thorough preparation and an extensive planning. Most essential is the groundwork and the design that determines the project's progress. There are many aspects to consider in order to avoid inconveniences such as delay, litigation, unexpected cost etcetera. If mistakes are made in an early stage it is very likely that the error will follow the process and become an expensive correction cost towards the later part of the project. In other words, it is expensive to rectify defects later on.

Title: Besparingar inom Barn- och utbildningsnämnden.Seminar date: 29th of May 2009Course: Degree thesis in Business Administration, bachelor thesisAuthors: Amela Smajlovic and Sten SundfeltAdvisor: Leif HolmbergPurpose: Our purpose is to explain the cost-saving process that many municipality organisations face because of the global financial crisis.Limitations: We have limited our study to the municipality of Landskrona and Kristianstad.Method: Our study has a qualitative approach. By using open interviews we have been able to get an open dialog with our respondents.Theory: We have compared with different theories, such as Rombach?s budget-theory and Wildavsky?s role theory.Empirics: The material is based on interviews and conversations with key figures in different levels of the organisations in Landskrona and Kristianstad.Conclusions: The success of a cost-saving process depends on the engagement, awareness and how inclined to changes the persons in the organisations are. Has everybody the willingness to take responsibility fore the organisation and the changes that the surrounding world claims?.

Introduction/Background: Economic evaluations help decision-makers to make informed decisions regarding resource allocation. Information generated from CEA can support evaluations of a new intervention with current praxis. The evaluations also provide information as to whether an intervention is cost-effective, both in economic terms and in health gains. Objective: The aim of this thesis is to investigate the use of economic evaluations in public health, with a focus on CEA. Use of economic evaluations is regarded as both a method for evaluation and as support for informed decisions.

I nuläget finns det ingen standard för utvärdering av mätosäkerheter för terrester laserskanner (TLS), detta trots att instrumentet funnits på marknaden och använts länge. Eftersom tillverkarens specifikationer inte alltid överensstämmer, är det viktigt att ha kunskap om hur bra instrumentet presterar. Ett flertal studier har under det senaste decenniet tillämpat olika metoder för att undersöka mätosäkerheten på olika TLS.Syftet med denna studie var att utvärdera och jämföra mätosäkerheterna mellan Leica ScanStation C10, som är en renodlad TLS, och Leica Nova MS50, som är en totalstation med skanningsfunktion, under två olika väderförhållanden. Osäkerheterna togs fram genom att använda ISO 17123-5:2012, som egentligen är en internationell standard för framtagande av totalstationers mätosäkerheter, för att undersöka om denna standard även kan appliceras på TLS. Undersökningen, som skedde utomhus vid Högskolan i Gävle, genomfördes genom att skanna signaler som ställts upp i en triangelformation från tre stationer.

This thesis project has been written and accomplished in cooperation with HABO AB. The objective of the project was to develop a standard stated packaging system. The background to this is that HABO is not pleased with the system currently in use. The system which HABO is currently using consists of to many sizes. The largest benefit of a standard stated system is that it becomes much easier to organize the packaging with the aid of a computer program.

The purpose of this study has been to evaluate whether a Low temperature bio-mass dryer could be integrated with the local district heating system in Malå. The aim is to increase the thermal efficiency of the cogeneration plant in Malå, by lowering the temperature of the cooling medium. Another benefit that comes from this is improved combustion efficiency at the power plant, since drying the fuel causes an Increase of the heating value.Simulations has been made in Excel, and with use of linear regression, to find out if it is profitable. Data for this purpose has been supplied by the power company Skellefteåkraft and furthermore SMHI.The result of the Calculations shows that a very efficient bio-mass dryer is needed, if yield of investments should be made possible. An Investment of 4,27 Mkr, in a dryer, could at a such criterium return 60000 kr/year, if the price of the biomass is 190kr/MWh.

Reglerna kring verkligt värde i IFRS i dag finns i många olika standarder och är ofta inte konsekventa. Definitionerna på verkligt värde varierar beroende på vad som ska värderas och det finns inte heller någon enhetlig beskrivning för hur värderingarna ska genomföras. I den amerikanska motsvarigheten till IFRS finns en standard som behandlar alla typer av värderingar till verkligt värde, SFAS 157. Där gäller definitionen för alla typer av tillgångar och skulder och en hierarki har skapats för att lätt kunna avgöra hur värderingarna ska ske.I november 2006 publicerade IASB ett förslag som innebär en stor förändring av hur verkligt värde ska redovisas enligt IFRS. IASB vill nämligen införa en enda standard för verkigt värde som ska baseras på SFAS 157.

This study concerns how organizations manage various problematic areaswhen implementeing Business Intelligence and experiences from BusinessIntelligence project failures on management level. In order to highlightthese questions, we have carried out interviews with four organizationswhich have great experience in working with Business Intelligence on adaily basis.The result of the study shows that all organizations deal with difficultiesregarding cost-benefit issues and justification concerning BusinessIntelligence investments. The result also showed that the organizationsfaced difficulties with integration concerning time and cost. Documentingand securing support systems presented different attitudes between theorganizations, primary in the question about sub complements to BusinessIntelligence and in the way that they were documented. In the discourse oflegal issues and privacy the majority of the organizations chose not to storepersonal information relative to legal security demands.

This essay analyses the national standard for maintenance aid and if it´s compatible with the standards set in the government mould.As new-liberal ideas get more scope in the Swedish policy the analyses focus consisted in seeing about the social contribution been changed, and if the standards in the government mould have lost their worth.The national standard is not edified on the basis of subsistence levels, but becomes paradoxical when numbers of welfare recipients is the measure used in order to measure poverty, concurrent as the government mould aims to protecting every citizen?s welfare.The study analyses a type of society that has emerged during a period of time. In a normative analysis concepts are set in relation to each other where, the analysis presents standards that are vague. If the standards in the government mould are presented as something valuable and get their worth back in the policy, perhaps also the citizen´s in Sweden change attitude to poverty and welfare contribution.   Social- liberalism justifies social contribution and the welfare State, while new-liberalism has other opinions about what redistribution should contain.

The thesis work has been carried out at Volvo Aero Corporation (VAC) in Trollhättan. VAC has entered a partnership as developing and producing partner with engine manufacturer Pratt & Whitney and is currently at the starting phase of producing the turbine rear frame (TEC) to the engine PW1000.The purpose of this study was to create a report on process level that describes the conditions and the potential with PW1000 TEC to reach the product cost calculation taking into account lead times and describe alternative method solutions.The report describes a comparison between the present flow (2012), a flow based on product cost calculation (2016) and a potential flow (2016). The work has mainly been based on acquiring the knowledge and information available to inspect the present flow; this has been done by workshop observations, meetings and gathering of the information that is available on the work site for the PW1000 TEC.The information obtained has been merged into an Excel document, called Roadmap. It serves as a roadmap with current situation as the start and the potential flow for 2016 as the goal. With the roadmap as a tool, assumptions have been taken considering the flow and how it will change, where processes have been eliminated, reduced or marked as a problem..

The standard model concerning the relationship between perception and motility is linear and one-way. It depicts the flow between the two as moving from sensation to perception to representation to computation, and finally, to motility and action. According to this model, animal being is basically a bundle of reflexes. But what can correctly be considered a bundle of reflexes from a natural science point of view, doesn't necessarily have to be true. This conception does not take into consideration the more complex interactions between motility and perception that constitutes, or generates, animal and human beings.

During the early 1990´s, the Swedish commercial air traffic was de-regulated and the new market-condition made it possible for low-budget airlines to enter the Swedish market. The former monopolistic airline company, Scandinavian Airline Systems (SAS), was facing a new type of competition which had the advantage of offering much cheaper air trips than SAS. Adding the decrease of profitability that struck SAS as well as other airline companies after the terrorist attacks on the 11th of September, forced them to carry out a mayor reorganization programme. The programme, called ?Turn Around 2005?, was a direct economical measure that begun in 2002 and lasted until 2005 and resulted in a cost saving of 14,5 billion SEK as well as a notice or a transfer of 6000 employees.The purpose of this essay is to investigate if the opinion of the consumer, the image, corresponds with the profile that SAS wishes to mediate today.

Gtherm is an innovation company who has an unique air heat exchanger underdevelopment. The purpose of this thesis is to provide data of suitable motors for theheat exchanger and to find suitable motor suppliers.A motor specification was designed. It is an important basis for the search of suitablemotors. A compilation was made of nine motor suppliers and the suitable motorsfrom those. The compilation can be used by GTherm in their choice of suppliers andmotors.The compilation of the demands on the motor and analysis of suppliers indicated thatthere were no standard motors available to GTherms air heat exchanger.

ISO14001:2004 : A Human Ecological Tool?This is a study by means of litterature analysis and personal experience to find out wheather you could call ISO14001:2004 a Human Ecological tool. The ISO14001 is an environmental management system. I'm approaching the issue from a users' perspective and putting my experience of implementing the ISO 9001 at my work to good use. Though my personal experience is limited to the implementation of the ISO 9001, it is quite relevant to the task since the update of 2004 the ISO14001:2004 is brought closer to the ISO 9001 standard in many ways.