Complete tumour regression is the optimal outcome of cancer therapies. There are however types of tumours that naturally regress. Most of these are benign, dermatological and have an early onset in life. This literature study aims to elucidate the mechanisms behind Spontaneous tumour regression. In Libechov Melanoblastoma-Bearing minipigs, an animal-model specifically bred to develop malignant melanoma, the tumours usually involute within three months.

"Landscapes for Spontaneous Sport" The main aim with this degree thesis is to show how planning and design of urban space can promote spontaneous sport. Public health and urban life would benefit from re-introducing the sport and physical activity in the townscape. The study can be seen as an "inspiration book" that focuses on the connection between sports and landscape architecture. The starting-point for the discussion is the fact that the spontaneous sport is on the decline and the main general question is how this negative trend could be broken. In particular the study asks how landscape architecture could promote and increase spontaneous sport. Good examples of places for spontaneous sports of different kinds are given, both from Sweden and from other countries, which have inspired a case study where I propose a redesign of a centrally located, but hardly used park in Skäggetorp, a suburb of the town of Linköping. .

This literature study aims to examine the existence of cancer stem cells in breast cancer. The cancer stem cell theory states that there is a hierarchical organization within a tumour, in which a small subpopulation of the cells can initiate new tumours and maintain tumour growth whilst the bulk of the tumour cannot. These tumour initiating cells have shown to possess many characteristics similar to those of adult stem cells, which is why they are often referred to as cancer stem cells. Both cell types have the capacity of asymmetric division and have shown to possess mechanisms of resistance to both apoptosis and cancer drugs. The cancer stem cell theory elucidates many biological aspects such as the heterogeneity of tumours and the relapse of many cancers after what appeared to be successful treatments.

The spontaneous blink rate is found to be a non-invasive but functional, reliable and useful way to monitor central dopaminergic activity. Dopamine is associated with a range of functions such as reward, motivation and learning. It plays an important role in goal-directed behavior and in maintaining a behavior once a task is learned. As far as the author knows, there are today no publications that discuss the topic regarding the possible link between training and spontaneous blink rate in dogs. Therefore, eight privately owned dogs were included in this study to determine if there was a significant difference in the spontaneous blink rate before and after the process of learning a task.

För alpina skidåkare mäter man prestationer i så kallad FIS-ranking. Vi undersöker några metoder för hur man kan analysera data där responsen består av ranger som dessa. Vid situationer då responsdata utgörs av urval av ranger finns ingen självklar analysmetod. Det vi undersöker är skillnaderna vid användandet av olika regressionsanpassningar så som linjär, logistisk och ordinal logistisk regression för att analysera data av denna typ. Vidare används bootstrap för att bilda konfidensintervall.

The WT1 gene is a complex gene originally known to suppress cancer in kidneys. Studies of WT1 knockout mice have confirmed the important role of WT1 in the pathogenesis of Wilms? tumour, a tumour which counts for 95% of all childhood renal tumours. In that case the WT1 gene acts as a tumour suppressor gene. Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, e g in leukemia or lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors).

En gren inom statistikteorin är den så kallade Regressionsanalysen där man studerar hur data från exempelvis ett stickprov kan anpassas till en graf. Skrivandet av denna uppsats har haft som syfte att studera några av de metoder som finns att tillgå vid bestämning av de ingående parametrarna i de enklare fallen av regression. Dessutom ges i de avslutande kapitlen exempel på den del inom regressionsanalysen som kallas Styckvis Linjär Regression eller Piecewise Linear Regression..

Being physically active is important for a healthty lifestyle, but what do the girls who have quit playing sports in an atheltic club do afterwards, or the girls who are not active within an athletic club what so ever. It is the girls who are not active in an athletic club that Karlstad municipality wants to attract to the spontaneous sports sites there are within the city limits. They also want the girls opinion on how to improve the sites in order for the girls to want to go there.The purpose with this study was to investigate this. This study used qalitative research method. The study interviewed seven girls aged 14-17 years.

Malt lymphoma is a malignant disease that can arise in a variety of extra nodal sites. Previous studies indicate that tumour arise from more mature B-cells.Our purpose was to examine the presence of clonality and somatic hypermutation of immunoglobulin (IgV?) of MALT lymphomas.Paraffin-embedded tumour samples from13 MALT lymphoma were subjected to rearrangement analysis, by using PCR, heteroduplex gels and sequence analysis.Successful amplification was seen in 10/13 cases and sequences of IgV? genes were obtained in 6/13, all of them were mutated. The percentage of mutation compared to germline sequences was 1,1% to 8,6% monoclonal rearrangemang. It was demonstrated that 5 of 7 clones were derived from the V?3 family, 2 from V?1 and 1 from the V? 4 family..

This paper presents the results of a workplace study of two smaller companies in the design industry. The core issue has been to investigate the companies use of technical tools and to what extent social praxis influence the daily work. The methods used are based on a qualitative analysis of interviews and observations. Various kind of work procedures, such as verbal and computerized, have been identified, but the most important occurrence was how spontaneous conversations between employees required certain flexibility, since the actors repeatedly were required to change focus and quickly perceive different information. For that reason, a thesis has been defined regarding how the use of spontaneous communication put an indirect need of a flexible working environment and also how this lead to more significant participation and exchange of information, as well as more awareness at the companies..

This thesis presents a system which has been implemented to satisfy a need in theresearch on how speech planning interacts with syntactic and prosodic structure inspontaneous speech. The long-term purpose of the research is to provide models forautomatic parsing of spontaneous speech and for psycholinguistical modelling of speechproduction. Identification of inhalation pauses is an important step in the developmentof automatic methods for spontaneous speech parsing.Identification of inhalation pauses is considered to be a keyword-spotting speechrecognition problem. Hybrid HMM(Hidden Markov Models)/ANN(Artificial NeuralNetworks) approach is applied to this problem. Method gets 90,8% in Recall, 66,4% inPrecision and 76,7% in F-score.

A controlled recording in a studio is the basis of all voice treatment. However, this controlled way of recording voice patients' voices can be questioned. The voice use may be different in a natural environment. In children noise related voice problems are investigated in a study about voice and its development (BUG ? Child voice and noise).

I uppsatsen kommer potentialen att prognostisera utfallet i svenska riksdagsval med logistisk regression och Seemingly Unrelated Regression (SUR) att undersökas. Estimeringarna baseras på svensk valdata från 1973 och framåt. Modellerna inkluderar makroekonomiska variabler såväl som indikatorer över de regeringens popularitet samt en tröttnadsvariabel. Resultaten tyder på att varken logistisk regression eller SUR är lämpliga att använda för prognostisering av svenska riksdagsval. Logistisk regression kräver en sådan förenkling av det politiska landskapet att några meningsfulla slutsatser är svåra att dra.

If customers respond differently to a campaign, it is worthwhile to find those customers who respond most positively and direct the campaign towards them. This can be done by using so called incremental response analysis where respondents from a campaign are compared with respondents from a control group. Customers with the highest increased response from the campaign will be selected and thus may increase the company?s return. Incremental response analysis is applied to the mobile operator Tres historical data.

Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.