The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

Varumärken inom B2B börjar få allt större uppmärksamhet bland forskare och företag i takt med att det uppmärksammats att varumärken har betydelse inom B2B-kontexter. Varumärket är ett av få sätt att differentiera sig på konkurrensintensiva marknader och kan medföra fördelar som en ökad kundlojalitet, premiumpriser och en ökad möjlighet att nå nya marknader. Samtidigt är forskningen om hur företag inom B2B bygger varumärken begränsad. B2B-marknader kännetecknas inte av produkterna utan av köparna som inte uteslutande är vinstrivande företag utan även kommuner, institutioner och icke- vinstrivande organisationer.I följande studie studeras underleverantörer vilka kännetecknas av dess förmåga att producera varor och tjänster till förmån för en köpare och dennes specifikationer. För en underleverantör är den grundläggande rollen att vara en värdeförmedlare som underlättar kundernas värdeskapande.

In the wake of the electronic revolution digital library has become one of the central themes concerning libraries. The present study takes up the question whether digital library can function in the same way as the conventional library. The question can obviously be posed from different perspectives, e.g. technological-, the user-, or the organizational perspective. The study investigates if (and how) digital library can have the same functions as the traditional library.

Boplatsvallar, often translated as semi-subterranean settlements, is an ancient monument with a diffuse definition. Defined as ?embankments that partially or completely surround a often lowered/dug down surface- this category of ancient monuments is also made up of a former category which traditionally was interpreted as winter settlements from the late Stone age in Sweden. This view of the ancient monuments carried over, to a certain extent, to this new definition. Should this be the case, that this category of ancient monuments are remains of winter settlements,  used recurringly over an extended period of time, then they should exhibit similar signals in regards to the distribution of the anthropogenically altered soil chemical and soil physical properties at the sites.The area around Lillsjön, Anundsjö parish in Ångermanland, have four boplatsvallar located separately in the regional area.

As collaboration between companies move beyond the single transaction into more long-term relationships the consequences of a company's control system become more complex. The aim of this paper is to provide an understanding of how intra- and inter-organizational control and work practices interact through examining how a company's intra-organizational control influences its customer relationships. The empirical research is performed through a qualitative case study where interviews have been conducted with management and sales staff within the case company as well as with one of the customers. The empirical findings have been analyzed using frameworks and theories regarding management control and customer relationships. The study reveals that the intra-organizational control of the case company affects its relationships with customers in a number of ways.

In past decades information technology has changed the conditions of organizations, not at least within the industry. Advanced IT systems have become a fact in order to cope with rapid changes in the market and to effectively manage an organization?s knowledge. When organizations became more flexible and customized expectations from customers and stakeholders also become higher. These expectations and guidelines are documented in a company?s management system, which can be designed differently depending on what standards the company chooses to implement.

Our population are ageing. As this happens more people will be in need of long term care facilities. We now know that some elderly people with certain background factors are more likely to be injured or sick. One of the four biggest background factors is fall propensity. Most of the reported falls come from long term care facilities, approximately 60 % of the care takers in long term care facilities fall one time or more each year.

The work examines geographical variations of bicycle use in Trondheim municipality with the aim to create an understanding of what influences the use of bicycles and explain the geographical travel pattern for cycling. The work focuses on the how physical structures generates different transports effects. Where bicycle travels in Trondheim municipality are undertaken is described by using network analysis in ArcGIS, based on aggregated data from the travel habit survey (RVU) in 2009/2010. Trondheim municipality is divided into smaller geographical units (zoner) whose characteristics are described by 19 variables, categorized into 6 groups; Distance, Land use, Topography, Bicycle Facilities, Road characteristics and Demographic factors.By linear regression analysis in SPSS and ArcGIS Spatial Analyst, an explanatory model is elaborated. The variablesdistance to the regional center, workplace density, percentage separate bike paths and hilly terrain explains 78 percent of where cycle journeys are undertaken.

Fossila drivmedel står idag för en överlägsen majoritet av den totala användningen av drivmedel som dagligen förburkas. Alternativ till de fossila drivmedlen krävs för att säkerställa tillgång i framtiden. Försvarsmakten har fått uppdrag från regeringen att utforska möjligheten att övergå till att driva sina fordon på förnyelsebara bränslen.Militära organisationer strävar efter ett enhetsdrivmedel, alltså ett gemensamt drivmedel som driver samtliga fordon och enheter. Största anledningen är den förenklade logistik som kan uppnås om endast ett drivmedel används.Detta arbete har sökt efter ett alternativt drivmedel som skulle kunna användas som enhetsdrivmedel inom Försvarsmakten. Detta för att lösa problematiken med att både byta till ett förnyelsebart drivmedel och ett enhetsdrivmedel i samma fas.Slutsatserna som dragit i detta arbete är att FT-bränslen har potential att användas som enhetsdrivmedel ur ett tekniskt perspektiv.

The purpose of this essay is to discuss relationality in G.W Leibnizs Monadologie (1714). In general terms this essay analyzes the notion of individuation in relation to the concept of monads. The analysis proposes a question regarding the body in this individuation, and what consequences follows for the understanding of the relation between the single individual and other individuals. It will be shown that the irreducibility of having a body transcendens something like ownness, subjectivity, personality and individuation, and this is explained through the pre-established harmony between the monads ? where the plurality of monads is detected before the monads singularity. To widen this investigation of relationality between the monads, I will turn to Edmund Husserls phenomenological operation for solving the egological problem of solipsism in Cartesian Meditations (1929). In his meditations, Husserl uses the monad as a self-conscious ego with peculiar ownness.

The aim of this study is to create an increased understanding of shared leadership and how it takes shape in the relationship between first-line managers in human service organizations. Shared leadership is seen as a complement to the traditional one-man leadership and briefly means that two managers share the role that usually is held by a single leader. The study has a qualitative approach based on semi-structured interviews with managers in human service organizations. The interviews mention the mangers thoughts and experiences about shared leadership and gain approval in the hermeneutic science field. The study is analyzed based on symbolic interactionism where perspectives from the theoreticians Mead and Goffman are used.

Several industrial scandals, especially those about Enron and WorldCom, have lead to an intense debate about the independent audit and the independent auditor. A substantial part of the auditor?s income originates from counselling, and therefore the role of the auditor may be seen as double, and the auditor?s objectivity may be questioned. In the year of 2002, a new Auditors Act was legislated in Sweden. In the 21 § of the act, a model based on principles was introduced, to test the auditor independence in every single case.

Many of todays studies show that district heating is one of the betteralternatives as heating source because of its low environmental load.The energy source is often leftovers from other processes producing energy or waste, like garbage or chips.Electricity in combination with geothermal heating is another heating system that has increased sharply during the last years, and also this system decreases the discharges that have negative affectson the environment compared to several other heating methods.This report aims to, concentrated towards these two different heating systems, estimate the amounts of discharges they indirect cause and how the environment is affected.We have calculated the mean value for discharges of carbon dioxide, nitrogen oxide, sulphur oxide and dust generated from electrical power used in Sweden.Through interviews and research we have gained data for the same substances that district heating based on combustion of garbage and biofuel generates.We have also in cooperation with a housing company chosen a building we see representative for many of the new single-family houses built in Sweden today.Based on its shape and appearance we theoretically created three alternatives of the same house, each of them with climate screens different from each other.Together with the amounts of discharged environmental affecting substances, these houses were the base for our calculations and studies when investigating the different heating sources environmental effect.The results have thereafter been analyzed and discussed from different angles..

This paper aims to provide a description of how knowledge can occur in Apoteket AB, anorganization that is operating on the Swedish pharmacy market. The purpose of this paper isalso to describe how the organizational learning occurs in the organization, and how theoutcome of this learning can be stored in the organizational memory. This subject is ofinterest since Apoteket AB experience changes in their external environment in that they nolonger have monopoly to sell pharmaceuticals on the Swedish pharmacy market. Earlierresearch claims that organizations need to develop new knowledge in order to take action, andthis development needs to be supported by the management within the organization.The collection of primary data was done by two qualitative interviews with employees withinthe organization of Apoteket AB.Our conclusions are that knowledge can occur in many forms, such as tacit and explicitknowledge. The vast majority of the knowledge within the organization is the information thatcan be found in the electronic database Aponet within Apoteket AB, and that is useful for theemployees in their daily work, and therefore is known as explicit knowledge.

The purpose of this thesis is to examine if and how bibliotherapy can be part of ordinary work in Swedish libraries. Questions: what is bibliotherapy and who can work with it? What are the conditions required? What does it mean to people taking part and to libraries? In this study bibliotherapy is delimited to fiction and activities including discussions, excluded are self-help books and the individuals private reading. The study is based on four qualitative interviews with librarian and bibliotherapists in Kirklees, England, partaking in nine bibliotherapeutic sessions and a literary survey, together forming a case-study. Conclusions: There is not a single answer to the question what bibliotherapy is, but if one puts stress on the biblio- part of the word, seeing reading as a normal activity it can be part of library work, whereas the therapy- part should be dealt with by professionals outside libraries.