High quality within a Lean production system begins with standardised work, which creates stable processes able to generate predictable output. If nonconformity from the standard procedures occurs, routines are needed to analyse, correct and prevent the nonconformity from occurring again. In that way, the nonconformity can be a trigger for continuous improvements toward more stable processes. In takted production lines, where the operator follows a standard sequence with tasks set to be completed within the takt time, a nonconformity leads to downtime in the operator?s sequence, and no value is added.

Matrix metalloproteinaser (MMPs) är en grupp proteolytiska enzymer som degraderar komponenter i vävnaders extracellulära matrix (ECM). Dessa proteiner spelar en viktig roll i många fysiologiska och patologiska processer. Enzymerna anses vara delaktiga vid olika typer av hjärtsjukdomar där de genom att utöva sin effekt påverkar sammansättningen hos ECM. Aktiviteten hos MMPs hämmas av TIMPs (tissue inhibitors of metalloproteinases) som är enzymernas specifika inhibitorer. Balans mellan nedbrytning och uppbyggnad av ECM är nödvändigt för att bibehålla hjärtvävnadens normala struktur och funktion.

There is convincing research which shows that the enzyme alkaline phosphatase (ALP) has a central role in the mineralization of bone, more precisely that its catalytic activity is needed in the process. ALP is found on the surface of matrix vesicles where the mineral is formed. One theory about the function of the enzyme is that it binds to fibrous collagen in the bone and thereby incorporating the mineral into the bone. The purpose of this study is to establish whether ALP binds to collagen. If this is the case, more elaborate studies around this will be performed.

En operation framkallar en icke önskvärd fysiologisk reaktion hos patienten som benämns som kroppens stressvar. Stressvaret innebär att sympatiska nervsystemet aktiveras och att endokrina ändringar erhålls, bland annat minskning i sekretionen av TSH och insulin samt ökning i sekretionen av ACTH, kortisol och ADH. En viktig uppgift för en veterinär är att välja premedicineringsläkemedel innan en operation. Premedicineringsläkemedel har som främsta uppgifter att motverka det perioperativa stressvaret hos djuret, minska smärta och förstärka anestesimedlens effekt. Syftet med det här arbetet är att beskriva vad som händer i kroppen vid ett perioperativt stressvar och hur svaret kan motverkas med hjälp av premedicineringsläkemedel. Premedicineringsläkemedel väljs och kombineras från klasserna sedativa, analgetika och antikolinergika. De vanligaste använda sederande läkemedlen på svenska veterinärkliniker är dopaminantagonisten acepromazin och alfa2-agonisten medetomidin.

Värmekollektor in Sunne is a company whose main occupation is to collect the gas produced inlandfills. The gas contains about 50 % of Methane which is a greenhouse gas 20 times worse than CO2and should therefore not be allowed to leak into the atmosphere. The Methane is in as large amount aspossible used in different plants for example heating of households. But there are occasions when aflare is needed to burn the excess gas at standstills or testing of new landfills. The Flare only burns themethane to reduce the hazarder?s effect of the environment, it does not take advantage of the energy inthe gasThe goal of this master thesis was for me to create a foundation for an in-house production offlares for Värmekollektor.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Ear disease and hearing loss in preschool children can be difficult to discover and diagnose. This paper investigates ear disease in 20 children controls from 1 to 5 years of age. The aim of the study was to map prevalence and incidence for ear disease, and prevalence of hearing loss in a group of children.Twenty children wide aged 1, 1½, 3 and 5 were included and investigated according to a set protocol with psychoacoustic tests, tympanometry, ear microscopy and a parental questionnaire. The majority of the children could be evaluated by age adequate psychoacoustic tests and otoscopy. Tympanometry was the investigation method that was most difficult to perform.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Highland Group AB was helping a customer of theirs to create an All-Terrain Vehicle (ATV), a project Highland has never been involved with before. For the wishbone arms of the wheel suspension, traditional manufacturing methods and tubes with cylindrical or square shaped cross section was preferred. We performed a simulation where the ATV was driving on a bumpy road too see the forces involved. With the results we proceeded to calculate the strength of the concepts to find out which is best suited for the tough environment in which the ATV is used. The concept that turned out to be the best was a wishbone made of circular cross section, which had good structural strength and did fulfill the demands that we required for the construction.

Dragbänken installerades på avdelning kallbearbetade rör på Ovako i Hofors 1990. Sedan dess har kvalitetskraven på de dragna rören ökat. Samtidigt har produktivitetskraven ökat, det vill säga att tillverka rör till rätt kostnad. I produktionsplaneringsprogrammet finns gränser och regler för hur de dragna rören ska tillverkas för att rätt kvalitet och kostnad ska uppnås. Eftersom både de dragna rören och de varmvalsade ingångsrören har ändrats med åren så stämmer inte alltid gränserna och reglerna idag.

Storm water causes a number of problems in our country, particularly in city environment with its surfaces of non-absorbing ground materials. At heavy rain falls there are floods due to lack of capacity in the drain system when meeting heavy water masses over a short time. When the drain system is overloaded huge water masses reach the recipient untreated and there causing disturbances in the aquatic ecosystem. Due to emissions from mainly traffic, industries and other human activities the storm water is polluted. Earlier the problem used to be solved technically, by increasing the capacity of the tubes and by construction of reservoirs to delay the floods peaks.

Bakgrund: I dag har 220 miljoner människor diabetes världen över och 90 % av dessa har typ 2 diabetes. Sjukdomen föregås alltid av en insulinresistens och eftersom den har en koppling till oxidativ stress är en teori att spårämnet selen kan spela en viktig roll. Det är känt att selen har antioxidativa effekter i kroppen och tidigare djurstudier har visat att selen skulle kunna härma insulinets effekter samt öka insulinkänsligheten.Syfte: Att ta reda på om selen kan skydda mot utvecklingen av typ 2 diabetes. De frågeställningar som användes var om selensupplementering, selenintag via kosten eller selenstatus i blod kan påverka risken att utveckla typ 2 diabetes hos friska individer.Sökväg: Datainsamlingen genomfördes i den medicinska databasen PubMed med sökorden ?selenium AND diabetes mellitus type 2?.

This report deals with the performance of a batch flow treatment of landfillleachate compared with a continuous flow system. The parameters in focus were total Kjeldahl nitrogen (TKN), BOD5 and COD. The pilot-scale experiment used eight barrels with a volume of 150 liters. Each barrel was constructed differently concerning its flow, its bed material grain size and its presence of plants or not. Four of the barrels worked in batch mode, thus four in continuous flow mode.

The aim of this study was to detect antibodies in swine serum against proteins in soy beans, wheat, oat and barley. Two methods were used: agar gel immunodiffusion test (AGID), and SDS-PAGE followed by immunoblotting. The sera examined originated (I) from piglets younger than one week (negative control), (II) pigs from a feed trial with soy bean in a herd with PMWS, and (III) pigs inoculated with Brachyspira hyodysenteriae and Escherichia coli after being fed with soy. The AGID-test was negative concerning all examined sera which were analysed against proteins in soy bean, wheat, oat and barley. In the experiment based on immunoblot antibodies were demonstrated within all three groups of examined pigs.