Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.

To establish good horse welfare there are several factors that need to be considered. One important factor is the environment in which the horses are kept. In Sweden horses are stabled during long periods of time in the cold season and consequently the stable environment is even more important. The most essential environmental factors in a horse stable are ambient temperature, relative humidity (RH) and concentrations of contaminants in the stable air. The air in a horse stable contains dust, noxious gases, moulds and microorganisms which all can contribute to developing Respiratory diseases in horses.

The aim of the study was to describe what it's like to live with Multiple Sclerosis (MS) and experiences of social support and being received and met by health personnel. The method was a qualitative interview study of descriptive design and was analyzed using qualitative content analysis. Three women and two men (26-75 years) with MS from two municipalitiesin central Sweden participated in the study. The main results showed that the participants felt the disease limited everyday life. The majority described feelings of injustice being affectedby the illness, but they now have a new perspective on life.

Rheumatoid arthritis (RA) is an autoimmune disease, which affects mostly women. RA is also a chronic disease and the treatment is focused on moderating the immunological process. RA-patients experience daily pain which affect their prosperity. The aim of this literature study is to illuminate some factors that influence the well-being of patients with RA. The factors that have been studied are pain, nutrition and need of knowledge about nutrition.

Kennelhosta är ett samlingsnamn för en grupp virus- och bakterieinfektioner som ofta drabbar hundar som är tillsammans med större grupper av andra hundar. Symptomen är oftast milda, vanligtvis med en torr, hackande hosta, men kan i vissa fall ta sig uttryck som svårare symptom som lunginflammation. De vanligaste infektionsämnena är hundens parainfluensavirus (CPIV), hundens respiratoriska coronavirus (CRCoV), hundens adenovirus typ 2 (CAV-2) och bakterien Bordetella bronchiseptica. Hundens respiratoriska coronavirus är det virus som undersöktes i studien som ligger till grund för den här rapporten. Familjen coronavirus innehåller de största membranomslutna virusen med RNA som arvsmassa med genomstorlekar på upp till 32000 baser.

Introduction: Diabetes type 1 is a common chronic disease in children and adolescents. The disease affect, not only the child, but also the parents in their everyday life. The specialist diabetic nurse has a huge responsibility in supporting the parents to feel confident in managing the child?s diabetes.Aims of the study: To investigate how parents of children with diabetes type 1 perceive the care given from the specialist diabetic nurse and what wishes they have concerning the care they receive.Design and methods: Searches for studies in electronic databases were conducted between January 2013 and march 2013. A literature review containing 16 studies was compiled.

Multiple sclerosis (MS) is one of our most common neurological diseases. The development of the disease often make the affected persons live with it for a long time. There are two types of the disease, the first is a progressive type and the other is relapsing remitting. Strengthening exercises isn?t commonly used as a treatment method although muscle weakness and fatigue are common symptoms.

Sahlgrenska Academyat University of GothenburgDepartment of internal medicine and clinical nutritionAbstractTitle: Can supplementation with vitamin E improve cognitive function in Alzheimer?s disease?Author: Malin Andersson and Elin LöfqvistSupervisor: Elisabet RothenbergExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: 2012-04-11Background: Alzheimer?s disease (AD) is the most common form of dementia. As the average life expectancy rises the prevalence increases. The disease leads to gradual deterioration of cognitive functions. A recent Cochrane review describes how several studies demonstrate an increased oxidative damage in the brain in those with AD.

Canine parvovirus is associated with two disorders: enteritis, which is common, and myocarditis, which is rare. Prominent clinical signs of parvovirus enteritis are vomiting, diarrhea and rapid dehydration. Canine parvovirus type 2 (CPV-2) is very contagious. When CPV-2 first emerged it had high rates of mortality, but later studies have shown that most infections are self-limiting and do not require veterinary care. Mortality rates vary greatly, and therefore it is important to determine risk factors for developing severe canine parvovirus enteritis.

Health and fitness are two controversial and not easily defined topics that affect people in our modern society every day. We believe that we can find a link between individualism, globalization and the stress concerning weight and appearance ideals. Our bodies have turned into a popular subject for the media, and there is no indication that the interest will decline. As the world gets more artificial, "natural" ideals are getting more attention, such as the concept of a strong and healthy body. But there is also a downside, for example with health issues such as cardiovascular disease increasing following the birth of high-fat diets.

The purpose of this report was to obtain an overview of rabbit meat production in the world, in terms of breeding and feeding. It examines how different feed components contribute to the health of the rabbit as well as the quality of the carcass, and the breeding strategies that are most common in the major producing countries. The production of rabbit meat in Sweden is at present not very large, but it is gaining ground, and that is why this paper mainly deals with the rabbit production abroad. This report also examines the disease Rabbit Viral Haermorrhagic Disease (RVHD) in Sweden, where this disease can cause big problems. The rabbit (Oryctolagus cuniculus) is very special, both in its reproduction and digestion. There is no specific mating season and the digestive tract is designed to digest forage efficiently.

Mammary tumors are the most frequent type of tumors in bitches in Sweden. Many studies have been published concerning mammary tumors, but there is still much to be learned about this disease. One has, since some time ago, had the knowledge that addition to or removal of methyl groups to genes can inhibit or activate gene-expression. Methylation and demethylation is a normal phenomenon in the body and it is essential for the development and survival of the individual. The risk of developing a tumor disease is increased if the global methylationstatus is changed; if oncogenes demethylates (activates) or if tumor suppressor genes methylates (inactivates). In the human medicine one has seen that there are differences in methylationstatus between different tumors. In this study tumor and normal tissue from ten dogs were examined with regard to methylationstatus.

The lions at Kolmårdens zoo are vaccinated against Feline Panleukopenivirus (FPV). In 1994 there was an outbreak among the lions at the zoo of FPV disease. A retrospective study has been made to measure the antibodytiters in vaccinated lions and lions that lived during the outbreak. An ImmunoPeroxidase Monolayer Assay (IPMA) was used to analyze the titers in the sera from the lions. Lions were divided into five groups. Group 1, 2 and 3 contained lions vaccinated one, two and three times respectively (a total of 40 animals). The lions of Group 4 were born in 2004 (six lioncubs) and were vaccinated according to different regimes and the changes in antibodytiters were followed as respose to vaccination during the spring 2005.

Pneumonia is a common disease in calves. There are several causes behind the disease. The main purpose of this litterary study was to estimate what kind of nursing calves with pneumonia could benefit from, especially the evidence-based nursing recommendations for the sick calves. A further purpose was to gain knowledge of different treatments of sick calves and what kind of practical measurements that are most suitable to use in the preventive work. The results in this study shows that there are only suggestions of nursing, rather than some actual evidence-based actions. The most important nursing actions is to isolate the calves with dyspnea, prevent or treatment of hypothermia, potential dehydration and malnutrition. It is also important to make sure to place the calf on soft and dry bedding.

Lung cancer is a disease which patients experience stigma in society and in care. This is because lung cancer is often seen as a self-inflicted disease. The stigma surrounding lung cancer is due to the strong relationship with smoking and have been shown to have a negative impact on the perceived health. The purpose of this study was to illuminate experiences of stigma for patients with lung cancer. The literature review was based on 11 scientific articles.