The search for antibiotic compounds from the natural environment has been going on for seven decades, ever since penicillin entered the market and antibiotic treatments became routine. The evolutionary pressure put on the pathogenic microorganisms induced a rapid spreading of naturally occurring resistance genes, leaving only the option of finding new antibiotics to treat the resistant pathogens. Microorganisms have been extensively mined for their biosynthetic abilities to produce biologically active compounds. To date, more than 23 000 microbial natural products have been discovered. The Actinomycetales are ubiquitous bacteria that have been used for antibiotic discovery for more than half a century, and over 10 000 natural products have been identified from the order.

In this paper I argue that the development of innovation ideas within the financial system of scientific research might have a counterpart within the financial system of the social sciences and the arts. The ideas of innovation share a common way to evaluate science in terms of how well it can contribute to economic growth. In the past two decades a similar development can be observed within Riksbankens Jubileumsfond (RJ), one of the largest external financiers of the social sciences and the arts in Sweden. The idea of evaluating research used by the innovation ideas has grown popular within RJ, only it seems they evaluate research in terms of how well it fits into an international research community rather than how much it can contribute to economic growth as is the case within the innovation ideas. By examining the different ways of financing research that RJ has used during the last 2 decades, this paper aims to introduce a new perspective in which it is possible to understand the development within this type research funding as a part of a bigger system of development..

Fusarium head blight is a large problem world wide which reduces the yields and the quality of small grains. Shrunken kernels with decreased thousand kernel weight as an effect and pro-duction of mycotoxins are some of the problems caused by infection of Fusarium spp. To avoid toxin contaminated bulks to enter the food and feed chain it is important to have tools for prediction and analysis of the fungi and toxins. Good prediction methods are also impor-tant in the breeding industry since early identification in trials of lines with high resistance or susceptibility simplify the work. To compare different techniques for these objectives this project was initiated.

Currently there is a controversial debate about that we must reduce our impact on the global warming; therefore both the Government and the local authorities have invested heavily in developing renewable energy in Sweden. The major development on the wind power market can be seen as a result of both the technological development and also on the decision that the Government took in 1996, which opened up the wind power market for private parties.This paper has aimed to examine the types of financial innovations that have arisen from the investments and financing of wind power on Gotland, and what these innovations can contribute to the future development of wind power.The problems that this thesis is based on is; what kind of financial innovations have occurred within investment and financing of wind power? How can these innovations contribute to the continued development of wind power on Gotland? The conclusion of this study shows that respondents and participants have defined a number of financial innovations that have emerged. Where some of the innovations only can be seen as incremental since they are based on continuous improvements, while others can be seen as radical as they are completely new for the context in which they operate. The study has also shown that Gotland has a great potential to produce more renewable electricity, but the development is dependent on the new power lines being built, in order to export electricity to the mainland..

Pharmaceuticals are environmental pollutants that are a major threat to aquatic ecosystems and very little is known about their ecological consequences. In this study growth, survival and behaviour (sociability, activity and boldness) of perch fry (Perca fluviatilis) were examined in order to study the possible effects of exposure to a benzodiazepine anxiolytic drug, Oxazepam, during embryonic development. The study tested following hypotheses: (1) perch growth is affected positively by exposure during embryonic development; (2) early perch survival is affected positively by exposure during embryonic development; and (3) boldness and activity increases while sociability decreases in perch fry exposed during embryonic development. Embryos of naturally spawned perch were exposed to water with two different concentrations of Oxazepam. The embryos were exposed during different parts (24-hour periods) of the embryonic development, because embryos may be more vulnerable at certain times during embryonic development and/or because the exposure at different times can produce different effects.

Design for Six Sigma (DFSS) is a further development of the Six Sigma draft to carry through preventing quality measures in developing and designing of new products and processes. With increasing demands on enterprises development processes to be more safety and faster the need of DFSS arise as a product, process and service development concept in the organisations. Design for Six Sigma aims to improve and structure the development process of an organisation and consider the application of the innovation problem solving. The concept aims to leave the structure of the traditional Six Sigma concept and instead, from an innovative perspective, search for new solutions to existing problems. The concept constitute of a toolbox with a lot of quality tools that are divided into phases in a development model.

Design for Six Sigma (DFSS) is a further development of the Six Sigma draft to carry through preventing quality measures in developing and designing of new products and processes. With increasing demands on enterprises development processes to be more safety and faster the need of DFSS arise as a product, process and service development concept in the organisations. Design for Six Sigma aims to improve and structure the development process of an organisation and consider the application of the innovation problem solving. The concept aims to leave the structure of the traditional Six Sigma concept and instead, from an innovative perspective, search for new solutions to existing problems. The concept constitute of a toolbox with a lot of quality tools that are divided into phases in a development model.

A flat organisation makes a horizontal career development possible, which means that it is more important to develop an individual?s knowledge base than to gain a higher title. This leads to a personal development, which motivates expats to stay. Since the responsibility of the career development mostly lies on expats themselves, companies should create conditions that make individual, internal job search possible. Like in IKEA:s case, it can be done through a strong and prestige less company culture, that penetrates the whole company.

År 1999 infördes principen om rule of law i Folkrepubliken Kinas konstitution - lagen skulle styra landet. De år av vanstyre som nådde sin kulmen under kulturrevolutionen hade åsidosatt lag och ordning och hade lett till att Folkrepubliken Kina vid tiden för Deng Xiaopings maktövertagande i slutet av 1970-talet stod utan ett rättssystem. Vid sidan om den ekonomiska reform som skulle öppna upp landet för världen gjordes därför enorma insatser för att etablera ett fungerande rättssystem. De kinesiska medborgarna fick många nya lagstadgade rättigheter, men på många håll runt om på den vidsträckta kinesiska landsbygden tillämpades lagarna inte till fullo av lokala styren som skaffade sig förmåner genom att inte tillämpa alla rättigheter. Bland de människor som inte fick ta del av rättigheterna formades rättmätigt motstånd ("rightful resistance") - motstånd med stöd av lag - som riktades mot illojala kadrar på lokal nivå.Sedan dess har rättmätigt motstånd ökat och är en aktuell fråga i dagens Kina.

Introduktion: Under de senaste tre decennierna har forskare försökt nå konsensus kring frågan om den möjliga hämmande effekten av kombinerad konditions- och styrketräning avseende utveckling av muskelstyrka jämfört med enbart styrketräning. Senaste meta-analysen inom området fastställdes 2012 och har kartlagt forskningsresultat fram till 2008, där konklusionen påvisar att forskningsresultaten är tvetydiga. Syfte: Att genomföra en systematisk litteraturstudie i form av en aktuell kunskapssammanställning över den forskning som bedrivits inom området för kombinerad konditions- och styrketräning för att undersöka om kombinerad träning har en hämmande effekt på utvecklingen av muskelstyrkan. Metod: Studien är en litteraturgenomgång där data samlats in via de medicinska databaserna; PubMed, Web of science, CINAHL, Scopus, AMED, Cochrane library och Physical education index. De sökord och sökordskombinationer som användes var; Concurrent training AND Endurance training AND Combined, Concurrent training AND Physical fitness AND Resistance training och Concurrent training AND endurance training AND Resistance training.

According to the Swedish preschool policy documents all children should have the same opportunities to develop their early language skills regardless of their social background. The purpose of this study is to investigate how preschool teachers work with children's early literacy and language development with focus on reading aloud. The reason is to investigate how the preschool teachers work to create an environment that stimulates children's literacy and language development. Another intention is to study how often reading aloud occurs in the children's home environment and what the preschool teachers thoughts are about that. The study is based on interviews with four preschool teachers and surveys that were answered by parents.

Fusarium head blight is a large problem world wide which reduces the yields and the quality of small grains. Shrunken kernels with decreased thousand kernel weight as an effect and pro-duction of mycotoxins are some of the problems caused by infection of Fusarium spp. To avoid toxin contaminated bulks to enter the food and feed chain it is important to have tools for prediction and analysis of the fungi and toxins. Good prediction methods are also impor-tant in the breeding industry since early identification in trials of lines with high resistance or susceptibility simplify the work. To compare different techniques for these objectives this project was initiated.

The purpose of my study is to investigate teacher?s perceptions of their mission in the preschool class, and how they work to promote children?s written language development. What methods and working methods they use to awaken curiosity and motivate children to read and write. I am using the qualitative research method to get answers to my questions. I have made four qualitative interviews with four teachers in preschool classes from different schools.My questions are:What conceptions does teachers have about their mission in a preschool class?What different methods and approaches does teachers use to stimulate and wake children?s curiosity for reading and writing development?The theoretical basis for my study is the socio-cultural perspective, where learning occurs in interaction.

Personal trainer is a profession that has grown strongly in recent decades, and has become increasingly common in the labor market within the health sector due to the widespread and growing interest in health and self- improvement. Further more, personal training is a great example of occupations with a close interaction between producer and consumer. The purpose of this study was to examine whether and if so how, personal trainers experience that the relationship with the clients affects their own personal development. This by finding out what impact the profession has had on the personality, what impact the relationship with the clients has affected the leadership, and last what impact the relationship with the clients have had on the personality based on social and mental aspects. Based on the purpose of the study qualitative method was chosen and data was collected with qualitative interviews.

The goal of this work has been to create a flexible strategic group-based artificial intelligence for the Arrowhead Game Studios-game Magicka, by implementing, using and examining different AI-techniques that's used in many commercial games in more or less extent. C# is the programming language that has been used in the development, and the implementation has been made as flexible as possible to make further development and extending AI-rules etc. easier..