Försämrat immunförsvar och ökad risk att drabbas av bakterie- och virusinfektioner förekommer hos patienter med blodsjukdomarna multipelt myelom, Waldenströms makroglobulinemi samt hos vissa patienter med blodsjukdomen monoklonal gammopati av oklar signifikans. Infektionerna kräver ofta antibiotikabehandling och behandling med antivirala medel. I dagsläget är det svårt att förutsäga vilka av patienterna som kommer att drabbas av svåra och ibland livshotande infektioner. Därför ges många av patienterna förebyggande antibiotikabehandling.I studiens början sattes en enzyme-linked immunosorbent assay (ELISA) för detektion av antikroppar mot Moraxella catarrhalis upp. I studien undersöktes om antikroppstitrar i serum mot bakterien Moraxella catarrhalis var lägre hos patientgrupperna än hos friska kontrollpersoner i samma ålder och om variationer förekom mellan patientgrupperna samt hur kontrollgrupper i olika åldrar skiljde sig från varandra.

A nonsense mutation in the DMRT3 gene has been shown to have a large impact on pattern of locomotion in horses. Horses that can perform several other gaits in addition to the normally occurring gaits, walk, trot and canter, are often hetero (CA)- or homozygous (AA) for this nonsense mutation. Horses that only can perform walk, trot and canter are often homozygous for the wild-type gene (CC). For example the Icelandic Horse is a gaited breed. Five-gaited Icelandic horses can perform both flying pace and tölt, except for the normally occurring gaits, walk, trot and canter, and are often homozygous for this nonsense mutation (AA).

Förhöjda halter av endotoxin i blodet förekommer ofta vid sjukdomen pyometra hos tik och kan orsaka många av de allmänna symtom som ses vid sjukdomen. Endotoxin Activity Assay (EAA) är en ny, snabb metod för mätning av endotoxinaktivitet i helblod. EAA-metoden är anpassad för humanpatienter, men har testats i forskningsstudier och visats fungera även för hundar och efter viss modifiering också för hästar. Två olika apparaturer från finns att tillgå för EAA (från Spectral Diagnostics Incorporated). Den apparatur som utvärderas i den här studien har aldrig tidigare testats på djurslaget hund.

SAMMANFATTNING Läkemedelsresistens är ett växande globalt problem. Inte minst bland parasiter hos våra djur har rapporter om utebliven effekt av läkemedel ökat. Pålitliga detektionsmetoder av anthelmintikaresistens hos nematoder är viktig så att åtgärder sätts in i ett tidigt skede för att djurvälfärd och produktion ej försämras. Detta kräver standardiserade och beprövade detektionsmetoder. De metoder som används idag för flertalet nematoder är ursprungligen framtagna och anpassade för strongylider hos får.

Rotavirus and coronavirus are the two most common viral causes of neonatal calf diarrhea and their presence causes a lot of economic damage to the farmers as well as suffering to the animal. By getting better knowledge about the viruses we may help in tracing transmission and in producing new vaccines. This paper served to study the molecular epidemiology of rotavirus and coronavirus in fecal samples collected from two different farms in the state of São Paulo, Brazil. These samples have been studied with focus on the gene VP4, VP7, NSP4 in rotavirus and the gene S1 in coronavirus. From the first farm the screening PCR showed that 12/48 samples were positive for rotavirus and 4/48 positive for coronavirus.

The analysis of acute phase protein serum amyloid A (SAA) has recently been brought into clinical use in veterinary medicine. Some of the difficulties with incorporating the SAA method in clinical practice have been the expensive and rather large equipment required for the method. Due to these difficulties only larger clinics can afford to use the SAA analysis.The company Equinostic has recently developed a smaller instrument that costs one-tenth of a larger instrument. The instrument is named EVA1 and has so far only been used to analyze SAA in horses.The aim of this study was to investigate if the EVA1 instrument could be used to analyze SAA in cats. This study included 24 serum samples from cat, which were first analyzed twice on the EVA1 instrument and then sent to the Strömsholm Referral Animal Hospital in Sweden where they reanalyzed the samples using a validated reference method.

Syntesdesign AB is an academic company that is supposed to enter the HIV drugmarket by manufacturing a "me-too"-drug with indinavir as the starting substance.Our task is to find 100 potential indinaviranalogues. Our further task is to suggesthow to perform a bondingassay to test the affinity for all these analogues. We willpresent a method, required equipment and calculated costs for the assay..

Serum thymidine kinase 1 (TK1) activity is used as a tumor marker in disease monitoring in veterinary and human medicine. TK1, an intracellular enzyme, is involved in a salvage pathway of DNA precursor synthesis. TK1 is used in DNA precursor production by catalyzing the transfer of the gamma-phosphate-group from a phosphate-donor to the 5?- hydroxyl-group of thymidine forming thymidine-monophosphate. Nucleoside monophosphosphates are finally converted into thymidine-triphosphates. TK1 activity significantly rises in the G1 and the S phase of the cell cycle.

The Swedish Red Polled breed is threatened by extinction and there are only around 1100 animals left. The breed was popular in the early twentieth century, but since then the numbers have steadily decreased. The overall objective of this study was to find out whether there may be economic incentives for preserving the breed. The milk quality properties are of major importance in the production of dairy products. Therefore we would like to establish if the Swedish Red Polled breed carries favourable alleles at loci of relevance for milk quality, to potentially make the breed more interesting for milk production.

This is a critical discourse analysis of the conformation of the conflict in Goma, Democratic Republic of the Congo, as constructed by Ekot, a news-show on Radio Sweden. The ambition of this bachelor thesis is to examine the production of a Congolese conflict for a Swedish audience and to find out how the construction differences with and without a reporter in the field. To obtain this purpose the narrative is studied as well as the use of voices that define the conflict. The construction of proximity between Swedish audience and the Congolese event and the meaning of sound to stabilize the formation of discourse within foreign news is examined as well. To conform and explain foreign news it must be put in relation to a starting point.

The development of quantitative, real-time PCR (qPCR) combined with the mapping of the canine genome opens new possibilities in veterinary medicine. This method provides a quick and accurate quantification of the expression of a specific gene at a given point in time and thereby also information of how the gene expression for a certain protein is influenced by various conditions and diseases. One possible area of application is identifying bio markers for cancer. Recently the protein serglycin (the core protein of an intracellular proteoglycan) was found to act as a selective marker for the disease acute myeloid leukemia in humans (Niemann et al, 2007). Serglycin is produced by most hematopoietic cells, although mast cells account for the largest amount of serglycin.

In 1993, Sweden signed the Convention on Biological Diversity and thus agreed to conserve our indigenous biological diversity. As a part of the convention, Sweden is obliged to conserve a number of domestic animal breeds and among them the Linderöd pig. In 1952, the zoo, Skånes Djurpark, took care of a pregnant sow that was regarded to be related to the old "forest pig". The old forest pig was thought to have been extinguished by the early 20th century as a result of the ban on boars not approved by state inspectors. However, according to later accounts, several farmers still kept some of these non-approved pigs.

African swine fever, ASF, was first described 1921, in Kenya. The virus has thereafter spread through many African countries as well as in Europe, Asia, South- and Central America. The virus is spread via three different cycles, of which one is sylvatic and includes warthogs and soft ticks. The other two are between domestic pigs and the one most common one is caused by humans, who not always realize the seriousness of precautions. The infection manifests as hemorrhagic fever, but can also be more or less unnoticed. The aim of this study was to use molecular tools to detect and partly genetically characterize ASFV both in soft ticks and in serum from domestic pigs in Uganda. Comparing viruses detected in ticks with those detected in domestic pigs I also wanted to investigate possible links between the sylvatic and domestic cycle.

SVT is Sweden?s largest TV-network and broadcasts more then 22 000 hours of TV each year. SVT is a public service company where the basic idea is to reflect the world from different perspectives and news is very important for providing neutral and versatile information in a variety of areas. An important part of the flow of information is to continuously receive reports from all corners of the world around the clock. This places very high demands on the technology used and it is important that it function and develops to meet current and future growing needs.

Titel: Genusframställningen i Star Trek ? en utopi eller dystopiFörfattare: Gustav Ekholm och Torbjörn KarlssonHandledare: Malin NilssonExaminator: Veronica StoehrelTyp av arbete: C-uppsats i Medie och Kommunikationsvetenskap, 10p HT-06Plats: Högskolan i HalmstadSyfte: Uppsatsen syfte är att fastställa huruvida åtta olika avsnitt ur tv-serien Star Trek belyser genusfrågor och utmanar avsnitten i så fall de rådande genusdiskurserna.Metod: Den här uppsatsen fokuserar på åtta Star Trek avsnitt som producerades mellan 1960-talet och 2000-talet. Metoden för analysen är en kritisk diskursanalys med utgång från Norman Fairclougs diskurskritiska modell.Resultat: Uppsatsens slutsats är att Star Trek-serierna berör genusfrågor i olika utsträckning beroende på vilket årtal avsnitten är från. Det konstateras också att viktiga genusämnen, likt homosexualitet, tas upp men beroende på olika omständigheter saknas ofta ett djup i framställningen.Nyckelord: Star Trek, Gene Roddenberry, science fiction, genus, diskurs, diskursanalys, textanalys, makt, tv-serier, dominansförhållanden..